Motif ID: Nhlh1

Z-value: 0.870


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_1720575980.191.6e-01Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_111808938 2.912 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chrX_+_35888808 2.657 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr7_-_28302238 2.546 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr2_+_158375638 2.483 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr9_-_57836706 2.104 ENSMUST00000164010.1
ENSMUST00000171444.1
ENSMUST00000098686.3
 Arid3b


AT rich interactive domain 3B (BRIGHT-like)


chr6_-_56362356 2.069 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr9_+_83834684 1.966 ENSMUST00000070326.7
 Ttk
Ttk protein kinase
chr2_-_60963192 1.906 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr13_+_24638636 1.876 ENSMUST00000110384.2
ENSMUST00000058009.9
ENSMUST00000038477.6
 Fam65b


family with sequence similarity 65, member B


chr14_+_56887795 1.871 ENSMUST00000022511.8
 Zmym2
zinc finger, MYM-type 2
chr2_+_102658640 1.864 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_-_72587544 1.849 ENSMUST00000031124.4
 Gm5868
predicted gene 5868
chr16_+_91269759 1.830 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr8_+_105518736 1.727 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr11_+_117849223 1.721 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr7_+_25152456 1.691 ENSMUST00000098678.1
 D930028M14Rik
RIKEN cDNA D930028M14 gene
chr6_+_104492790 1.595 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
 Cntn6


contactin 6


chr1_-_52500679 1.583 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr11_+_99864476 1.560 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr6_+_14901344 1.538 ENSMUST00000115477.1
 Foxp2
forkhead box P2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 400 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 3.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.6 3.1 GO:0007386 compartment pattern specification(GO:0007386)
0.1 3.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.4 2.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 2.7 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.0 2.7 GO:0050821 protein stabilization(GO:0050821)
0.2 2.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 2.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.4 2.3 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.1 2.2 GO:0007608 sensory perception of smell(GO:0007608)
0.3 2.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.6 1.9 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 1.9 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2 1.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 1.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 1.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 1.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.3 1.7 GO:0090383 phagosome acidification(GO:0090383)
0.0 1.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0016605 PML body(GO:0016605)
0.1 4.2 GO:0031941 filamentous actin(GO:0031941)
0.1 3.8 GO:0030673 axolemma(GO:0030673)
0.0 3.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.2 GO:0060077 inhibitory synapse(GO:0060077)
0.6 2.9 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.0 2.5 GO:0000776 kinetochore(GO:0000776)
0.1 1.9 GO:0030904 retromer complex(GO:0030904)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.5 GO:0090544 BAF-type complex(GO:0090544)
0.3 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.2 1.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 1.3 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0005112 Notch binding(GO:0005112)
0.0 5.3 GO:0003779 actin binding(GO:0003779)
0.0 5.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.0 GO:0001047 core promoter binding(GO:0001047)
0.1 3.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 3.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.7 2.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 2.8 GO:0003774 motor activity(GO:0003774)
0.1 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 2.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.5 GO:0005109 frizzled binding(GO:0005109)
0.3 2.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 2.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.4 2.0 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.0 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 1.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 5.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.3 4.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.5 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.8 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 1.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 1.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases