Motif ID: Nkx2-1

Z-value: 0.586


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56535047_565351060.576.2e-06Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_89688196 6.553 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr11_+_117849223 5.850 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr14_-_47411666 5.716 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr12_+_103314944 5.623 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr8_-_46294592 4.769 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr16_+_48994185 4.457 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 4.280 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr19_+_44493472 3.926 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr15_-_88978958 3.846 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr4_-_141874879 3.274 ENSMUST00000036854.3
 Efhd2
EF hand domain containing 2
chr10_+_88091070 3.100 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chrX_+_100730178 2.777 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr4_-_109665249 2.766 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr14_+_75455957 2.663 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr2_+_121506715 2.469 ENSMUST00000028676.5
 Wdr76
WD repeat domain 76
chr2_+_121506748 2.384 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chrX_+_58030999 2.296 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr1_+_97024681 2.290 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr1_-_181842334 2.193 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr17_+_47737030 2.115 ENSMUST00000086932.3
 Tfeb
transcription factor EB

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 6.6 GO:0060179 male mating behavior(GO:0060179)
0.2 4.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 4.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 4.5 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.7 4.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 3.8 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.0 3.4 GO:0007050 cell cycle arrest(GO:0007050)
1.0 3.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 3.1 GO:0032288 myelin assembly(GO:0032288)
0.3 2.8 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.5 2.7 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 2.2 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 2.2 GO:0006814 sodium ion transport(GO:0006814)
1.1 2.1 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.6 1.9 GO:0072034 renal vesicle induction(GO:0072034)
0.1 1.6 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 1.5 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.5 1.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 10.1 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.3 5.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 5.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.0 2.8 GO:0005884 actin filament(GO:0005884)
0.0 2.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 2.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.2 1.8 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 1.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.3 GO:0043218 compact myelin(GO:0043218)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.2 GO:0002177 manchette(GO:0002177)
0.0 1.2 GO:1990391 DNA repair complex(GO:1990391)
0.1 1.0 GO:0032039 integrator complex(GO:0032039)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 9.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 7.5 GO:0045296 cadherin binding(GO:0045296)
0.0 5.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 5.1 GO:0005109 frizzled binding(GO:0005109)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
0.0 3.3 GO:0008565 protein transporter activity(GO:0008565)
0.2 3.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.0 GO:0005272 sodium channel activity(GO:0005272)
0.3 2.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3 2.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 2.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 2.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 1.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 3.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 1.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4 1.2 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)