Motif ID: Nkx2-1
Z-value: 0.586
Transcription factors associated with Nkx2-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-1 | ENSMUSG00000001496.9 | Nkx2-1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-1 | mm10_v2_chr12_-_56535047_56535106 | 0.57 | 6.2e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 10.1 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 1.1 | 2.1 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 1.0 | 3.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.7 | 4.2 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.7 | 6.6 | GO:0060179 | male mating behavior(GO:0060179) |
| 0.6 | 1.9 | GO:0072034 | renal vesicle induction(GO:0072034) |
| 0.5 | 2.7 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.5 | 1.4 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.4 | 1.2 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.4 | 3.8 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397) |
| 0.3 | 1.3 | GO:0021502 | neural fold elevation formation(GO:0021502) |
| 0.3 | 4.8 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.3 | 2.8 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.3 | 1.1 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.3 | 1.1 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 0.9 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.2 | 4.9 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.2 | 1.2 | GO:1904587 | response to glycoprotein(GO:1904587) |
| 0.2 | 1.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.2 | 0.6 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.2 | 1.2 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.1 | 1.6 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.1 | 1.5 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 1.3 | GO:0032306 | regulation of prostaglandin secretion(GO:0032306) |
| 0.1 | 3.1 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 0.5 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 2.8 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.1 | 0.4 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 0.1 | 0.5 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 1.2 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 1.0 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.1 | 0.5 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.1 | 0.7 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.1 | 1.0 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 4.5 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
| 0.1 | 1.0 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 2.2 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.0 | 0.1 | GO:0046013 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.0 | 0.2 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.0 | 0.4 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.0 | 3.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.4 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 1.2 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.4 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 2.2 | GO:0006814 | sodium ion transport(GO:0006814) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 10.1 | GO:0032133 | interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133) |
| 0.3 | 5.7 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 1.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.2 | 1.8 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 2.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 1.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 1.2 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 1.3 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 0.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.0 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.5 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.8 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.3 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 3.8 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.2 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 2.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 5.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 2.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 2.0 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.8 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.3 | 2.9 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.3 | 2.2 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.2 | 10.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 1.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 2.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 0.2 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762) |
| 0.2 | 1.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.2 | 3.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 0.9 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 1.3 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 5.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.3 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 1.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.5 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 3.0 | GO:0005272 | sodium channel activity(GO:0005272) |
| 0.1 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 1.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.5 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.0 | 0.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 1.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.5 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 1.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 5.7 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 3.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 1.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.4 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 1.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.3 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 1.4 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.0 | 0.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 9.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 7.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.2 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 3.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.3 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.8 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 0.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.4 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.9 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 3.3 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 1.3 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 5.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.6 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.2 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 1.0 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.2 | 1.9 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 3.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 10.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.2 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 2.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 5.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.3 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.5 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 2.8 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.2 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.2 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.4 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.0 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
