Motif ID: Nkx2-2
Z-value: 1.532
Transcription factors associated with Nkx2-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-2 | ENSMUSG00000027434.10 | Nkx2-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-2 | mm10_v2_chr2_-_147186389_147186413 | 0.17 | 2.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.6 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 3.1 | 9.2 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 2.4 | 7.1 | GO:1904959 | elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
| 2.2 | 8.8 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 1.3 | 3.9 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 1.2 | 6.0 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 1.1 | 18.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 1.1 | 4.5 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 1.0 | 5.2 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 1.0 | 4.8 | GO:0060242 | contact inhibition(GO:0060242) |
| 1.0 | 3.9 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.8 | 4.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.8 | 3.0 | GO:0046073 | dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073) |
| 0.8 | 5.3 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.6 | 1.9 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.6 | 3.1 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.5 | 3.8 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.5 | 6.8 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.5 | 1.4 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.4 | 1.3 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.4 | 11.9 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.4 | 4.1 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.4 | 3.5 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.4 | 0.8 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.4 | 2.5 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.4 | 1.1 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.3 | 4.1 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.3 | 2.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.3 | 1.3 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.3 | 1.5 | GO:0035617 | stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.3 | 0.9 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.3 | 5.2 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.3 | 1.1 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.3 | 1.6 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.2 | 1.2 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.2 | 0.7 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.2 | 0.9 | GO:0035087 | siRNA loading onto RISC involved in RNA interference(GO:0035087) |
| 0.2 | 1.1 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.2 | 4.3 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.2 | 3.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.2 | 1.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.2 | 0.8 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 0.8 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.2 | 5.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 1.6 | GO:0000022 | mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256) |
| 0.2 | 0.5 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.2 | 0.6 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.1 | 3.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 5.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 0.3 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.1 | 0.5 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.1 | 0.8 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.1 | 0.3 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.1 | 2.5 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 1.8 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 1.0 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 1.9 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 5.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 0.5 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.9 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
| 0.1 | 0.6 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 1.2 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 1.3 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.2 | GO:0039702 | viral budding via host ESCRT complex(GO:0039702) |
| 0.1 | 0.2 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.1 | 0.6 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 6.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 0.6 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 0.6 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 3.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 4.7 | GO:0017156 | calcium ion regulated exocytosis(GO:0017156) |
| 0.1 | 1.6 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 1.9 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 0.4 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.1 | 0.3 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 0.3 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.1 | 0.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 4.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.1 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.0 | 0.1 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.0 | 2.4 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.2 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 2.0 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.9 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.0 | 1.9 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 1.6 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.4 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.7 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.0 | 2.0 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 1.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 3.5 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.0 | 0.1 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 0.2 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 3.8 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 2.3 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 1.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 2.4 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.0 | 0.2 | GO:0008209 | androgen metabolic process(GO:0008209) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 1.2 | 4.6 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.5 | 1.9 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.5 | 8.8 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.4 | 3.1 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.4 | 5.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.3 | 4.0 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 4.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 18.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 0.8 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.2 | 7.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.2 | 1.0 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 6.2 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 0.9 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.2 | 15.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 1.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.2 | 2.0 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 4.2 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 1.2 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 0.8 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.1 | 1.9 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 3.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 1.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 2.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.9 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.1 | 5.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.5 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 4.5 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 2.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 5.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 9.0 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 2.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 3.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 5.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 1.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 3.4 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 2.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 3.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.8 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 0.7 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 2.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 9.7 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 0.3 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597) |
| 0.0 | 2.0 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 6.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 17.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 2.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 0.3 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 2.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.8 | GO:0005929 | cilium(GO:0005929) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.1 | GO:0043682 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 1.5 | 11.9 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 1.3 | 5.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.1 | 6.8 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.9 | 4.3 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.8 | 2.4 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.7 | 4.2 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.6 | 3.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.6 | 5.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.5 | 10.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.5 | 2.1 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.5 | 4.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.5 | 9.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 4.5 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.3 | 6.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.3 | 1.2 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.3 | 1.8 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 0.8 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.2 | 1.9 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 1.5 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.2 | 1.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.2 | 3.0 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.2 | 5.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.2 | 0.9 | GO:0035197 | siRNA binding(GO:0035197) |
| 0.2 | 1.6 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.2 | 4.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.2 | 4.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 1.2 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 1.6 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 5.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.8 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 2.3 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 1.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.4 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.1 | 4.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 1.1 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.0 | 0.3 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.6 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 2.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 2.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 6.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.2 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 1.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 1.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 1.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.4 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 2.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 3.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.0 | 1.7 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 6.1 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 4.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.2 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.0 | 3.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 11.0 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 0.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 1.5 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 2.3 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 17.4 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.0 | 0.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 5.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 5.2 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.1 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 13.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.0 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 3.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 1.8 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.6 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.5 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 3.0 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 1.9 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.1 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 10.6 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 3.9 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 3.0 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.3 | 4.1 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 5.2 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 1.0 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 7.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 5.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 3.0 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 4.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 9.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.9 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.2 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 3.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.5 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 0.8 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 3.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.2 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.9 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 2.5 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.3 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 2.8 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 3.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.3 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 1.2 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.5 | REACTOME_CIRCADIAN_CLOCK | Genes involved in Circadian Clock |
