Motif ID: Nkx2-2

Z-value: 1.532


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.172.0e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_19418930 11.674 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 11.319 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3034599 10.592 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 9.912 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 9.894 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3017408 9.848 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 9.764 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_72438534 9.324 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr10_+_88091070 9.200 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr9_+_72438519 8.839 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr11_+_78301529 8.805 ENSMUST00000045026.3
 Spag5
sperm associated antigen 5
chr3_+_5218516 8.367 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_+_62664279 6.392 ENSMUST00000028257.2
 Gca
grancalcin
chr1_-_135688094 6.206 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr4_+_59626189 6.027 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr19_-_5796924 6.011 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrX_+_9885622 5.869 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr2_-_140170528 5.859 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr2_-_84775420 5.376 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775388 5.265 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 18.2 GO:0070986 left/right axis specification(GO:0070986)
0.4 11.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
3.5 10.6 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
3.1 9.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
2.2 8.8 GO:0090235 regulation of metaphase plate congression(GO:0090235)
2.4 7.1 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.5 6.8 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 6.2 GO:0001578 microtubule bundle formation(GO:0001578)
1.2 6.0 GO:0035063 nuclear speck organization(GO:0035063)
0.2 5.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 5.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.8 5.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.0 5.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 5.2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 5.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.0 4.8 GO:0060242 contact inhibition(GO:0060242)
0.1 4.7 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
1.1 4.5 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.2 4.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.8 4.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 GO:0005882 intermediate filament(GO:0005882)
0.0 17.1 GO:0005615 extracellular space(GO:0005615)
0.2 15.0 GO:0072562 blood microparticle(GO:0072562)
0.0 9.7 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 9.0 GO:0005813 centrosome(GO:0005813)
0.5 8.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 7.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 6.6 GO:0016607 nuclear speck(GO:0016607)
0.2 6.2 GO:0043194 axon initial segment(GO:0043194)
0.0 5.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 5.6 GO:0000922 spindle pole(GO:0000922)
0.4 5.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 5.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.6 4.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.2 4.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 4.5 GO:0005902 microvillus(GO:0005902)
0.2 4.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.3 4.1 GO:0005922 connexon complex(GO:0005922)
0.3 4.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 3.9 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.4 GO:0042802 identical protein binding(GO:0042802)
1.5 11.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 11.0 GO:0008270 zinc ion binding(GO:0008270)
0.5 10.6 GO:0001848 complement binding(GO:0001848)
0.5 9.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
2.4 7.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.1 6.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 6.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 6.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 6.1 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 5.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 5.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.6 5.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
1.3 5.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 4.8 GO:0070064 proline-rich region binding(GO:0070064)
0.3 4.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 4.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 4.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.7 4.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.1 PID_ATM_PATHWAY ATM pathway
0.1 3.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 3.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.0 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 10.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 9.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 7.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 5.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 5.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 4.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 4.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 3.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 3.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 3.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 3.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 3.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins