Motif ID: Nkx2-3

Z-value: 0.781


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.541.8e-05Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 15.359 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 12.775 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr6_-_23248264 6.661 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_-_6882068 5.636 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr2_+_73271925 5.609 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr19_-_59170978 5.150 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr12_+_38780284 4.721 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr14_-_118052235 4.326 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_+_6730051 4.136 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr12_+_38780817 4.130 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr1_+_6734827 3.986 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr2_+_22622183 3.917 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr5_+_139543889 3.361 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_152847993 3.201 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr14_+_73237891 3.200 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr12_-_56535047 3.131 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr3_-_36571952 3.084 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr14_+_75455957 3.075 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr7_+_144838590 3.002 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr19_+_43612299 2.975 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 39.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 8.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 7.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
1.1 6.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.9 5.6 GO:0060166 olfactory pit development(GO:0060166)
1.8 5.4 GO:0021759 globus pallidus development(GO:0021759)
0.6 5.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.4 4.8 GO:0060539 diaphragm development(GO:0060539)
0.7 4.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.8 3.9 GO:0006538 glutamate catabolic process(GO:0006538)
0.9 3.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 3.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 3.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 3.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 3.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.6 3.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 3.1 GO:0016572 histone phosphorylation(GO:0016572)
0.1 3.1 GO:0032611 interleukin-1 beta production(GO:0032611)
0.5 3.0 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 3.0 GO:0030916 otic vesicle formation(GO:0030916)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0032993 protein-DNA complex(GO:0032993)
0.2 4.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.6 3.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 3.2 GO:0005818 aster(GO:0005818)
0.1 3.2 GO:0043034 costamere(GO:0043034)
0.4 3.1 GO:0001940 male pronucleus(GO:0001940)
0.2 2.7 GO:0042788 polysomal ribosome(GO:0042788)
0.4 2.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 2.6 GO:0060077 inhibitory synapse(GO:0060077)
0.4 2.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 2.2 GO:0005922 connexon complex(GO:0005922)
0.1 2.0 GO:0032590 dendrite membrane(GO:0032590)
0.3 1.9 GO:0098536 deuterosome(GO:0098536)
0.0 1.9 GO:0043296 apical junction complex(GO:0043296)
0.5 1.5 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.4 1.5 GO:0060187 cell pole(GO:0060187)
0.3 1.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.5 GO:0033269 internode region of axon(GO:0033269)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 13.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 10.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 7.0 GO:0051015 actin filament binding(GO:0051015)
0.3 5.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 5.5 GO:0001047 core promoter binding(GO:0001047)
0.1 4.6 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.3 4.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 4.3 GO:0071837 HMG box domain binding(GO:0071837)
0.6 3.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.7 3.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 3.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 3.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.5 3.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 3.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 3.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 2.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 2.7 GO:0017091 AU-rich element binding(GO:0017091)
0.2 2.4 GO:0043522 leucine zipper domain binding(GO:0043522)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 41.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 3.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 3.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 3.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 3.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 3.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.5 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.5 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL