Motif ID: Nkx2-4

Z-value: 0.485


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.114.1e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_178798438 3.212 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr10_+_4611971 2.829 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr7_-_115824699 2.779 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr14_-_47418407 2.623 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_+_99055164 2.477 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr13_+_108316395 2.473 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr2_+_25180737 2.076 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr12_-_91746020 1.894 ENSMUST00000166967.1
 Ston2
stonin 2
chr10_+_88091070 1.836 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_-_102579461 1.785 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr13_+_65512678 1.763 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr6_+_30568367 1.546 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr9_+_108560422 1.450 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr15_-_26895049 1.376 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr1_+_97024681 1.356 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr10_+_20347788 1.350 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr8_+_45627946 1.278 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 1.230 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr6_+_134929089 1.219 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr13_-_66852017 1.215 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 3.2 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.7 2.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 2.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.5 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.2 2.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.6 1.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 1.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 1.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.3 GO:0000266 mitochondrial fission(GO:0000266)
0.1 1.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 1.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 0.9 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 0.7 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.1 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0005871 kinesin complex(GO:0005871)
0.4 2.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.8 2.5 GO:0044299 C-fiber(GO:0044299)
0.0 1.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.5 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.5 GO:0032009 early phagosome(GO:0032009)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 2.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 2.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 1.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.7 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.5 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 0.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells