Motif ID: Nkx2-4

Z-value: 0.485


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.114.1e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_178798438 3.212 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr10_+_4611971 2.829 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr7_-_115824699 2.779 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr14_-_47418407 2.623 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_+_99055164 2.477 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr13_+_108316395 2.473 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr2_+_25180737 2.076 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr12_-_91746020 1.894 ENSMUST00000166967.1
 Ston2
stonin 2
chr10_+_88091070 1.836 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_-_102579461 1.785 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr13_+_65512678 1.763 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr6_+_30568367 1.546 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr9_+_108560422 1.450 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr15_-_26895049 1.376 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr1_+_97024681 1.356 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr10_+_20347788 1.350 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr8_+_45627946 1.278 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 1.230 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr6_+_134929089 1.219 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr13_-_66852017 1.215 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr2_+_156840966 1.215 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr10_+_128232065 1.110 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr6_+_134929118 1.072 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr9_-_71896047 0.983 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr12_+_38781093 0.916 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr7_-_132813095 0.733 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chr12_+_38780817 0.701 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr8_+_66860215 0.662 ENSMUST00000118009.1
 Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr6_+_29398920 0.617 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr11_+_101733011 0.576 ENSMUST00000129741.1
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr19_-_6969746 0.557 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr2_+_30061754 0.554 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr2_+_169632996 0.517 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr17_-_25844417 0.516 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr3_-_110250963 0.493 ENSMUST00000106567.1
 Prmt6
protein arginine N-methyltransferase 6
chr11_+_98863610 0.473 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr10_+_42502197 0.458 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chr16_+_32419696 0.451 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr2_+_157456917 0.438 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr19_+_55741810 0.418 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr11_+_101732950 0.418 ENSMUST00000039152.7
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr2_-_27507656 0.383 ENSMUST00000154316.1
 Brd3
bromodomain containing 3
chr17_-_25844514 0.367 ENSMUST00000176709.1
 Rhot2
ras homolog gene family, member T2
chr14_+_48446128 0.360 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr2_-_93046053 0.349 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr4_-_108848619 0.325 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr7_-_100932140 0.321 ENSMUST00000107032.1
 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr13_+_3478226 0.312 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
 2810429I04Rik


RIKEN cDNA 2810429I04 gene


chr12_-_105685235 0.299 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr3_+_76593550 0.296 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr3_+_121291725 0.274 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr1_+_34439851 0.267 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr7_-_34812677 0.249 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr2_-_147186389 0.239 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr3_+_96696379 0.229 ENSMUST00000107076.3
 Pias3
protein inhibitor of activated STAT 3
chr11_-_103697661 0.220 ENSMUST00000107013.2
 Gosr2
golgi SNAP receptor complex member 2
chr3_+_88629499 0.211 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr13_-_105271039 0.209 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr4_-_40279389 0.183 ENSMUST00000108108.2
ENSMUST00000095128.3
 Ndufb6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6

chrX_+_56447965 0.183 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr8_+_45627709 0.171 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chrX_-_140956675 0.159 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr1_-_34439672 0.143 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr2_+_169633517 0.139 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr4_+_62525369 0.125 ENSMUST00000062145.1
 4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr14_+_55672235 0.111 ENSMUST00000002397.5
 Gmpr2
guanosine monophosphate reductase 2
chr15_-_100669496 0.107 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr6_-_97060407 0.103 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr15_-_100669535 0.092 ENSMUST00000183211.1
 Bin2
bridging integrator 2
chr19_-_45742873 0.087 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr15_-_100669512 0.072 ENSMUST00000182574.1
ENSMUST00000182775.1
 Bin2

bridging integrator 2

chrX_+_101383726 0.060 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr11_+_110968056 0.056 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr8_-_31739763 0.052 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr6_+_123229843 0.047 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr11_+_110968016 0.024 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr5_+_34999111 0.012 ENSMUST00000114283.1
 Rgs12
regulator of G-protein signaling 12
chr11_+_87592897 0.011 ENSMUST00000119628.1
 Mtmr4
myotubularin related protein 4
chr14_-_55671873 0.004 ENSMUST00000163750.1
ENSMUST00000010520.8
 Nedd8

neural precursor cell expressed, developmentally down-regulated gene 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.7 2.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.6 1.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.4 1.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.3 1.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 2.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 2.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 1.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.6 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.1 0.7 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.1 0.5 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 2.5 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 1.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 2.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.4 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.9 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 1.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0046037 GMP metabolic process(GO:0046037)
0.0 0.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 3.2 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 0.1 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0044804 nucleophagy(GO:0044804)
0.0 0.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0044299 C-fiber(GO:0044299)
0.4 2.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.5 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 3.2 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0032009 early phagosome(GO:0032009)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.7 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.5 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 3.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.7 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors