Motif ID: Nkx2-6

Z-value: 0.316


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116031047 4.115 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr4_-_109665249 3.161 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr15_-_78773452 3.135 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_91399984 1.880 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_116237767 1.747 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr5_+_110330697 1.061 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr1_+_156035392 1.041 ENSMUST00000111757.3
 Tor1aip2
torsin A interacting protein 2
chr1_-_156034800 0.703 ENSMUST00000169241.1
 Tor1aip1
torsin A interacting protein 1
chr1_-_156034826 0.621 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr10_+_100488289 0.531 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr3_+_87525572 0.481 ENSMUST00000170036.1
ENSMUST00000117293.1
 Etv3

ets variant gene 3

chr4_+_62619515 0.478 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr2_+_23069210 0.388 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr2_-_121456693 0.186 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr2_-_147186389 0.073 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr1_+_179960472 0.058 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 1.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 1.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 3.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 3.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.0 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.5 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.7 GO:0005915 zonula adherens(GO:0005915)
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 1.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 3.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 2.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 3.2 REACTOME_G1_PHASE Genes involved in G1 Phase