Motif ID: Nkx2-9
Z-value: 0.807
Transcription factors associated with Nkx2-9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-9 | ENSMUSG00000058669.7 | Nkx2-9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-9 | mm10_v2_chr12_-_56613270_56613291 | 0.12 | 3.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 9.6 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 2.0 | 14.0 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 1.9 | 5.7 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 1.8 | 5.4 | GO:0021759 | globus pallidus development(GO:0021759) |
| 1.1 | 4.2 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.0 | 3.1 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.7 | 2.1 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.7 | 8.4 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.7 | 2.7 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.6 | 3.1 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.6 | 6.2 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397) |
| 0.4 | 1.3 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.4 | 6.3 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.4 | 4.9 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.3 | 1.0 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 0.3 | 1.2 | GO:0021502 | neural fold elevation formation(GO:0021502) |
| 0.3 | 3.1 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.3 | 0.8 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 0.3 | 1.3 | GO:2000483 | response to bacterial lipoprotein(GO:0032493) negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.3 | 2.3 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.3 | 2.5 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.2 | 4.9 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.2 | 1.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.2 | 1.9 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.2 | 1.0 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.2 | 0.8 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
| 0.1 | 0.7 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 1.0 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.1 | 0.9 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.1 | 2.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 0.5 | GO:0048318 | axial mesoderm development(GO:0048318) |
| 0.1 | 1.2 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.1 | 0.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.9 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 2.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.1 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 3.3 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.1 | 0.7 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 2.7 | GO:0042775 | mitochondrial ATP synthesis coupled electron transport(GO:0042775) |
| 0.0 | 6.0 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 1.8 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 1.5 | GO:0007588 | excretion(GO:0007588) |
| 0.0 | 1.0 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 0.1 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.0 | 0.1 | GO:0046013 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.0 | 1.6 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.1 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.0 | 0.4 | GO:2000278 | regulation of DNA biosynthetic process(GO:2000278) |
| 0.0 | 0.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.0 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.0 | 4.3 | GO:0006260 | DNA replication(GO:0006260) |
| 0.0 | 0.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 1.9 | GO:0006457 | protein folding(GO:0006457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 14.0 | GO:0032133 | interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133) |
| 1.4 | 8.4 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.2 | 0.9 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.2 | 3.2 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 1.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 1.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.3 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 9.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 4.8 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 0.5 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 6.2 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.1 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 9.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 0.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.1 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.1 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 1.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 2.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.5 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 4.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.2 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.8 | 8.4 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.7 | 3.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.4 | 5.4 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.4 | 3.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.4 | 1.6 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
| 0.4 | 3.9 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.4 | 9.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.3 | 14.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.3 | 5.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 0.9 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.2 | 2.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 0.8 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.2 | 1.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 2.1 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 1.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 1.3 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 3.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.8 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.1 | 2.3 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.1 | 1.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.9 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 0.6 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 1.0 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 2.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.5 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 0.9 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 0.7 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.1 | 1.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
| 0.1 | 6.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.0 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.7 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.4 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 1.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.2 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.4 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 1.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 1.9 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.2 | 9.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.4 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.1 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.8 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.7 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.5 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.7 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.0 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 16.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 3.9 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 1.7 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 4.2 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 0.6 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 5.8 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.6 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.4 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.8 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.8 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 1.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.7 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.8 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.2 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
