Motif ID: Nkx2-9

Z-value: 0.807


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.123.7e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_30065333 9.562 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_+_57504012 8.447 ENSMUST00000080514.7
 Rpp25
ribonuclease P/MRP 25 subunit
chr11_+_117849223 7.973 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr15_-_88978958 6.153 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr11_+_117849286 5.985 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr2_+_20737306 5.981 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr10_+_88091070 5.652 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr12_-_56536895 5.383 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr6_+_135362931 4.918 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr8_-_46294592 4.855 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr2_+_173022360 4.575 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr8_+_95633500 4.343 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr6_-_6217023 4.244 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr18_+_77185815 3.909 ENSMUST00000079618.4
 St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr11_+_88718442 3.521 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr16_-_33380717 3.485 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr1_-_181842334 3.336 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr4_+_8690399 3.117 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr14_+_75455957 3.117 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr7_-_142576492 3.071 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 14.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
3.2 9.6 GO:0021557 oculomotor nerve development(GO:0021557)
0.7 8.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.4 6.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.6 6.2 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.0 6.0 GO:0048706 embryonic skeletal system development(GO:0048706)
1.9 5.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
1.8 5.4 GO:0021759 globus pallidus development(GO:0021759)
0.4 4.9 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 4.9 GO:0032060 bleb assembly(GO:0032060)
0.0 4.3 GO:0006260 DNA replication(GO:0006260)
1.1 4.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.3 GO:0016126 sterol biosynthetic process(GO:0016126)
1.0 3.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.6 3.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 3.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 2.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.7 2.7 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 2.7 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.3 2.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 14.0 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.1 9.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 9.8 GO:0005667 transcription factor complex(GO:0005667)
1.4 8.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 6.2 GO:0005901 caveola(GO:0005901)
0.1 4.8 GO:0005844 polysome(GO:0005844)
0.0 4.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 3.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 3.2 GO:0005652 nuclear lamina(GO:0005652)
0.1 2.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0043596 nuclear replication fork(GO:0043596)
0.1 1.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 0.9 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 9.6 GO:0008432 JUN kinase binding(GO:0008432)
0.8 8.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 6.4 GO:0008565 protein transporter activity(GO:0008565)
0.3 5.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 5.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.1 4.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.7 3.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.4 3.9 GO:0042301 phosphate ion binding(GO:0042301)
0.4 3.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 3.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.3 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 2.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.9 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 9.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 9.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 5.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 3.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.6 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.1 0.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol