Motif ID: Nkx3-1

Z-value: 0.730


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 143 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_100625737 9.000 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr10_-_13324160 7.446 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr3_-_57575760 6.404 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 6.354 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr6_+_128362919 6.249 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr9_+_78191966 5.751 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr4_-_132757162 5.674 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr9_+_72438534 5.550 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 5.184 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr17_+_56304313 4.458 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr1_-_163289214 3.685 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr10_-_13324250 3.370 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr17_-_25727364 3.314 ENSMUST00000170070.1
ENSMUST00000048054.7
 Chtf18

CTF18, chromosome transmission fidelity factor 18

chr1_-_133907053 3.269 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr4_+_116708571 3.194 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr8_+_114133557 3.194 ENSMUST00000073521.5
ENSMUST00000066514.6
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr8_-_123318553 3.149 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A

chr2_-_84775420 3.059 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr8_+_114133635 2.997 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr2_-_84775388 2.970 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.8 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.7 10.7 GO:0070986 left/right axis specification(GO:0070986)
0.9 9.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
2.1 6.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.6 6.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
2.0 6.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.8 5.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 5.7 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.3 4.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.3 3.7 GO:0048664 neuron fate determination(GO:0048664)
0.4 3.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.4 3.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 2.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.7 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.7 2.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 2.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.4 2.2 GO:0036337 Fas signaling pathway(GO:0036337)
0.0 2.2 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.6 1.9 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0005667 transcription factor complex(GO:0005667)
0.2 10.7 GO:0005882 intermediate filament(GO:0005882)
0.1 9.1 GO:0005871 kinesin complex(GO:0005871)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.5 GO:0000791 euchromatin(GO:0000791)
0.0 4.5 GO:0072562 blood microparticle(GO:0072562)
0.0 4.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 3.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 3.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 3.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.7 GO:0032420 stereocilium(GO:0032420)
0.0 2.6 GO:0005814 centriole(GO:0005814)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.7 GO:0070938 contractile ring(GO:0070938)
0.5 1.6 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 1.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.6 GO:0005884 actin filament(GO:0005884)
0.3 1.5 GO:0032389 MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 9.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 8.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 7.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
2.1 6.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 6.0 GO:0001848 complement binding(GO:0001848)
0.7 5.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.1 4.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 3.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.3 3.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 2.9 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 2.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 2.4 GO:0034618 arginine binding(GO:0034618)
0.3 2.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.2 2.0 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.6 1.9 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 3.1 PID_BARD1_PATHWAY BARD1 signaling events
0.0 3.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 7.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.6 6.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 3.1 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.9 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.3 2.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 2.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.2 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI