Motif ID: Nkx3-2

Z-value: 0.563


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 4.458 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr2_-_104409992 4.090 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr16_+_41532851 3.745 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr3_-_80802789 3.213 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr5_-_139130159 3.099 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_-_82074639 3.010 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr9_-_21037775 2.867 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr4_+_102421518 2.847 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_136171722 2.807 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr9_+_57940104 2.734 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr11_+_3332426 2.258 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr3_+_123267445 2.233 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr10_+_38965515 2.223 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr14_+_80000292 2.054 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_156992021 2.010 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
 Ndrg3


N-myc downstream regulated gene 3


chr6_-_138421379 1.963 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr10_-_86732409 1.936 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr4_-_120747248 1.906 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr11_+_43474276 1.725 ENSMUST00000173002.1
ENSMUST00000057679.3
 C1qtnf2

C1q and tumor necrosis factor related protein 2

chr17_+_70561739 1.712 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 GO:0035641 locomotory exploration behavior(GO:0035641)
0.4 4.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.3 3.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 3.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.0 3.0 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.7 2.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 2.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 2.7 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.4 2.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.6 2.2 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.2 2.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 2.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 1.9 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.4 1.7 GO:0009597 detection of virus(GO:0009597)
0.1 1.7 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.1 1.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.4 1.3 GO:0019085 early viral transcription(GO:0019085)
0.3 1.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 6.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 3.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 3.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 2.2 GO:0005605 basal lamina(GO:0005605)
0.1 2.2 GO:0097440 apical dendrite(GO:0097440)
0.1 2.1 GO:0042581 specific granule(GO:0042581)
0.0 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.3 GO:0042641 actomyosin(GO:0042641)
0.4 1.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.2 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 3.5 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.3 3.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 3.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 3.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 3.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 2.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.6 GO:0000149 SNARE binding(GO:0000149)
0.8 2.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.5 1.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.4 1.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.3 1.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 1.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 3.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 2.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 1.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 6.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 3.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation