Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.719

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_1016652260.211.2e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 10.582 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_98053415 9.589 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr15_+_18818895 5.950 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr3_-_49757257 5.370 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr15_+_25773985 4.963 ENSMUST00000125667.1
 Myo10
myosin X
chr1_-_155417394 4.912 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr2_-_79456750 4.035 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr6_-_101377897 3.904 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr14_-_100149764 3.714 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr13_+_44121167 3.713 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr5_-_84417359 3.553 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chrM_+_9870 3.489 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrX_-_143933089 3.474 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_+_118478182 3.438 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_24612700 3.406 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chrX_+_56454871 2.922 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr2_+_116067213 2.780 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr7_+_29071597 2.725 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr9_+_118478344 2.644 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr16_+_42907563 2.608 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2 6.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
2.0 6.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 5.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.4 5.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 5.0 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 4.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 4.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 4.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.0 4.0 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 3.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.9 3.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 3.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.1 3.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.8 3.3 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
1.1 3.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 3.2 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.1 2.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.9 2.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 2.5 GO:0097475 motor neuron migration(GO:0097475)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0030427 site of polarized growth(GO:0030427)
0.1 5.0 GO:0016459 myosin complex(GO:0016459)
0.0 4.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 4.5 GO:0070469 respiratory chain(GO:0070469)
0.0 3.8 GO:0072562 blood microparticle(GO:0072562)
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.8 3.2 GO:0060187 cell pole(GO:0060187)
0.1 2.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 2.5 GO:0097440 apical dendrite(GO:0097440)
0.1 2.5 GO:0031672 A band(GO:0031672)
0.8 2.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 2.4 GO:0051286 cell tip(GO:0051286)
0.0 2.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.5 2.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.9 GO:0071565 nBAF complex(GO:0071565)
0.0 1.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.2 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 11.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 7.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 7.7 GO:0005509 calcium ion binding(GO:0005509)
2.3 6.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 6.5 GO:0030507 spectrin binding(GO:0030507)
0.2 5.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 5.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 4.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 3.8 GO:0008017 microtubule binding(GO:0008017)
0.1 3.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 2.8 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.6 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 2.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2 2.4 GO:0050693 LBD domain binding(GO:0050693)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.3 GO:0019905 syntaxin binding(GO:0019905)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.4 PID_ARF6_PATHWAY Arf6 signaling events
0.2 8.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 6.1 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.9 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 4.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 3.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 2.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.1 REACTOME_MYOGENESIS Genes involved in Myogenesis