Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.507

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.283.8e-02Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 147 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 5.773 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr14_+_80000292 3.715 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_+_94083490 3.585 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr4_+_102589687 3.134 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr4_-_14621494 2.967 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr5_-_118244861 2.706 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr4_-_14621669 2.591 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr17_-_81649607 2.562 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr16_+_11406618 2.542 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr14_+_69347587 2.421 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr10_-_110000219 2.158 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr5_+_144100387 2.114 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr8_-_21906412 1.898 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr5_-_70842617 1.896 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr13_+_83732438 1.810 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr15_-_33687840 1.798 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chrX_-_143933089 1.666 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_125136692 1.534 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr5_+_29195983 1.348 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
 Rnf32




ring finger protein 32




chr17_-_45659312 1.343 ENSMUST00000120717.1
 Capn11
calpain 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.3 GO:0019532 oxalate transport(GO:0019532)
0.3 4.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 2.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 2.6 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.1 2.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 2.1 GO:0033572 transferrin transport(GO:0033572)
0.6 1.9 GO:0015866 ADP transport(GO:0015866)
0.3 1.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 1.8 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.4 1.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.1 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.3 1.0 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.0 GO:0032570 response to progesterone(GO:0032570)
0.1 1.0 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 0.9 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.7 GO:0030426 growth cone(GO:0030426)
0.3 3.7 GO:0042581 specific granule(GO:0042581)
0.1 3.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.5 GO:0034707 chloride channel complex(GO:0034707)
0.8 2.4 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 4.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.6 2.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 2.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 2.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.6 1.9 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 1.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.2 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.3 0.8 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 2.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones