Motif ID: Nr0b1

Z-value: 0.771


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.076.0e-01Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_19094594 6.818 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr16_-_45844228 6.194 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844303 6.194 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr11_+_102604370 4.953 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr7_+_79500081 4.746 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr7_+_79500018 4.680 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr17_-_70851189 4.301 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr1_-_9700209 4.040 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr9_+_80165079 3.804 ENSMUST00000184480.1
 Myo6
myosin VI
chr9_+_80165013 3.294 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr5_+_64803513 3.022 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr1_+_42697146 3.013 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr5_-_99037035 2.973 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr10_-_81350389 2.949 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr2_-_54085542 2.901 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr18_+_35829798 2.838 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr11_+_94328242 2.738 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr5_-_99037342 2.637 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chr14_+_11553523 2.594 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_+_94327984 2.409 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 7.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.5 6.8 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.8 5.6 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
1.0 5.0 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223) hard palate development(GO:0060022)
1.1 4.4 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 4.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 3.0 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.2 2.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 2.9 GO:0007050 cell cycle arrest(GO:0007050)
0.4 2.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.6 2.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 2.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 2.2 GO:1901998 toxin transport(GO:1901998)
0.1 2.0 GO:0070207 protein homotrimerization(GO:0070207)
0.5 1.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.3 1.6 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 1.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.4 GO:0045180 basal cortex(GO:0045180)
0.0 7.3 GO:0031965 nuclear membrane(GO:0031965)
0.3 7.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 5.0 GO:0005925 focal adhesion(GO:0005925)
0.0 3.8 GO:0030027 lamellipodium(GO:0030027)
0.7 2.9 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 2.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.2 GO:0097440 apical dendrite(GO:0097440)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0045298 tubulin complex(GO:0045298)
0.1 0.9 GO:0000235 astral microtubule(GO:0000235)
0.2 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0005882 intermediate filament(GO:0005882)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 7.1 GO:0003774 motor activity(GO:0003774)
0.0 6.7 GO:0045296 cadherin binding(GO:0045296)
1.4 5.6 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 5.6 GO:0008432 JUN kinase binding(GO:0008432)
0.2 5.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.9 4.4 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.5 4.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 3.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 2.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.0 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.4 1.9 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.4 GO:0071253 connexin binding(GO:0071253)
0.0 1.4 GO:0051018 protein kinase A binding(GO:0051018)
0.2 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 5.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.8 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.4 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 5.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 5.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 2.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.8 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery