Motif ID: Nr1h2

Z-value: 0.965


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.482.0e-04Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_53159885 11.699 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 7.421 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr16_-_37384915 5.692 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr10_-_109823585 5.021 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr11_-_60210410 4.541 ENSMUST00000144942.1
Srebf1
sterol regulatory element binding transcription factor 1
chr5_-_124327883 4.093 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr11_+_84179792 3.934 ENSMUST00000137500.2
ENSMUST00000130012.2
Acaca

acetyl-Coenzyme A carboxylase alpha

chr16_-_37384940 3.899 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr13_+_44729794 3.728 ENSMUST00000172830.1
Jarid2
jumonji, AT rich interactive domain 2
chr3_-_148989316 3.653 ENSMUST00000098518.2
Lphn2
latrophilin 2
chr2_+_102658640 3.636 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_+_79895017 3.483 ENSMUST00000023054.7
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr2_-_113829069 3.409 ENSMUST00000024005.7
Scg5
secretogranin V
chr13_-_12461432 3.363 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
Lgals8



lectin, galactose binding, soluble 8



chr8_-_84773381 3.151 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr11_+_84179852 3.109 ENSMUST00000136463.2
Acaca
acetyl-Coenzyme A carboxylase alpha
chr3_+_62419668 3.105 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr7_+_114768736 2.922 ENSMUST00000117543.1
Insc
inscuteable homolog (Drosophila)
chr5_+_76840597 2.767 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
C530008M17Rik


RIKEN cDNA C530008M17 gene


chr5_+_123015010 2.619 ENSMUST00000121652.1
ENSMUST00000051016.4
Orai1

ORAI calcium release-activated calcium modulator 1

chrX_-_102644210 2.264 ENSMUST00000052012.7
ENSMUST00000043596.5
ENSMUST00000119229.1
ENSMUST00000122022.1
ENSMUST00000120270.1
ENSMUST00000113611.2
Phka1





phosphorylase kinase alpha 1





chr18_+_37333853 2.205 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr1_+_58711488 2.122 ENSMUST00000097722.2
ENSMUST00000114313.1
Cflar

CASP8 and FADD-like apoptosis regulator

chr2_+_155382186 2.009 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr1_+_6214627 1.969 ENSMUST00000027040.6
Rb1cc1
RB1-inducible coiled-coil 1
chr1_+_135729147 1.923 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr4_-_141538562 1.884 ENSMUST00000105786.2
Spen
SPEN homolog, transcriptional regulator (Drosophila)
chr11_-_30025915 1.883 ENSMUST00000058902.5
Eml6
echinoderm microtubule associated protein like 6
chr11_+_93996082 1.820 ENSMUST00000041956.7
Spag9
sperm associated antigen 9
chr2_-_33087169 1.798 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_126876209 1.792 ENSMUST00000103224.3
Trpm7
transient receptor potential cation channel, subfamily M, member 7
chr4_-_141538434 1.787 ENSMUST00000078886.3
Spen
SPEN homolog, transcriptional regulator (Drosophila)
chr6_+_90462562 1.635 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr7_-_80371197 1.626 ENSMUST00000098346.3
Man2a2
mannosidase 2, alpha 2
chr1_+_57377593 1.613 ENSMUST00000042734.2
1700066M21Rik
RIKEN cDNA 1700066M21 gene
chr5_-_100159261 1.610 ENSMUST00000139520.1
Tmem150c
transmembrane protein 150C
chr9_-_42472198 1.595 ENSMUST00000128959.1
ENSMUST00000066148.5
ENSMUST00000138506.1
Tbcel


tubulin folding cofactor E-like


chr5_+_124194894 1.591 ENSMUST00000159053.1
ENSMUST00000162577.1
Gm16338

predicted gene 16338

chr5_-_136565432 1.499 ENSMUST00000176172.1
Cux1
cut-like homeobox 1
chr11_-_102556122 1.467 ENSMUST00000143842.1
Gpatch8
G patch domain containing 8
chr17_-_79715034 1.410 ENSMUST00000024894.1
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr7_+_81523531 1.406 ENSMUST00000181903.1
2900076A07Rik
RIKEN cDNA 2900076A07 gene
chr7_+_81523555 1.367 ENSMUST00000180385.1
ENSMUST00000180879.1
ENSMUST00000181164.1
ENSMUST00000181264.1
2900076A07Rik



RIKEN cDNA 2900076A07 gene



chr2_+_158306493 1.359 ENSMUST00000016168.2
ENSMUST00000109491.1
Lbp

lipopolysaccharide binding protein

chr7_-_27446599 1.345 ENSMUST00000011895.7
Sptbn4
spectrin beta, non-erythrocytic 4
chr2_+_30266721 1.334 ENSMUST00000113645.1
ENSMUST00000133877.1
ENSMUST00000139719.1
ENSMUST00000113643.1
ENSMUST00000150695.1
Phyhd1




phytanoyl-CoA dioxygenase domain containing 1




chr11_-_69948145 1.323 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr17_-_25985641 1.296 ENSMUST00000041641.8
Capn15
calpain 15
chr2_+_154548888 1.163 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr6_-_134632388 1.153 ENSMUST00000047443.3
Mansc1
MANSC domain containing 1
chr2_+_131491764 1.133 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr5_+_103754154 1.109 ENSMUST00000054979.3
Aff1
AF4/FMR2 family, member 1
chr2_+_61593125 1.097 ENSMUST00000112494.1
Tank
TRAF family member-associated Nf-kappa B activator
chr5_+_107331157 1.081 ENSMUST00000031215.8
ENSMUST00000112677.3
Brdt

bromodomain, testis-specific

chr9_+_77941274 1.022 ENSMUST00000134072.1
Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr10_+_18845071 1.017 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr8_-_36249292 0.990 ENSMUST00000065297.5
Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr15_+_65787023 0.970 ENSMUST00000015146.9
ENSMUST00000173858.1
ENSMUST00000172756.1
ENSMUST00000174856.1
Efr3a



EFR3 homolog A (S. cerevisiae)



chr6_+_124663027 0.970 ENSMUST00000004381.7
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr5_-_120588613 0.968 ENSMUST00000046426.8
Tpcn1
two pore channel 1
chr14_-_72602945 0.966 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr15_+_85832301 0.964 ENSMUST00000146088.1
Ttc38
tetratricopeptide repeat domain 38
chr8_+_4238815 0.963 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr17_+_49428359 0.933 ENSMUST00000165390.2
ENSMUST00000024797.9
ENSMUST00000173033.1
Mocs1


molybdenum cofactor synthesis 1


chr4_-_129440800 0.932 ENSMUST00000053042.5
ENSMUST00000106046.1
Zbtb8b

zinc finger and BTB domain containing 8b

chr5_+_124328083 0.914 ENSMUST00000111477.1
ENSMUST00000077376.2
2810006K23Rik

RIKEN cDNA 2810006K23 gene

chr4_+_123859651 0.908 ENSMUST00000097896.2
4933427I04Rik
Riken cDNA 4933427I04 gene
chr15_-_79328154 0.890 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr15_+_76879232 0.870 ENSMUST00000023179.5
Zfp7
zinc finger protein 7
chr15_-_79328201 0.833 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6



phospholipase A2, group VI



chr16_+_16870736 0.795 ENSMUST00000139740.1
ENSMUST00000119787.2
ENSMUST00000130650.1
ENSMUST00000156502.1
ENSMUST00000023465.7
ENSMUST00000124960.1
ENSMUST00000144513.1
Top3b






topoisomerase (DNA) III beta






chr7_+_27862557 0.787 ENSMUST00000053722.8
Zfp607
zinc finger proten 607
chr16_+_13940630 0.774 ENSMUST00000141971.1
ENSMUST00000124947.1
ENSMUST00000023360.7
ENSMUST00000143697.1
Mpv17l



Mpv17 transgene, kidney disease mutant-like



chr7_-_133776681 0.771 ENSMUST00000130182.1
ENSMUST00000106139.1
Dhx32

DEAH (Asp-Glu-Ala-His) box polypeptide 32

chr17_-_56716788 0.766 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr7_+_112953955 0.739 ENSMUST00000182858.1
Rassf10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr12_+_87147703 0.733 ENSMUST00000063117.8
Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr12_-_87147883 0.719 ENSMUST00000037788.4
Pomt2
protein-O-mannosyltransferase 2
chr1_-_164458345 0.703 ENSMUST00000027863.7
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_+_155381808 0.700 ENSMUST00000043237.7
ENSMUST00000174685.1
Trp53inp2

transformation related protein 53 inducible nuclear protein 2

chr2_-_164911586 0.690 ENSMUST00000041361.7
Zfp335
zinc finger protein 335
chr16_+_16870829 0.666 ENSMUST00000131063.1
Top3b
topoisomerase (DNA) III beta
chr1_+_132506230 0.663 ENSMUST00000058167.1
Tmem81
transmembrane protein 81
chr2_+_61593077 0.652 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator

chr4_-_44167580 0.619 ENSMUST00000098098.2
Rnf38
ring finger protein 38
chrX_-_155216338 0.615 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chr8_+_4238733 0.611 ENSMUST00000110998.2
ENSMUST00000062686.4
Map2k7

mitogen-activated protein kinase kinase 7

chr11_+_82952095 0.609 ENSMUST00000108158.2
ENSMUST00000067443.2
Slfn5

schlafen 5

chr19_-_5845471 0.601 ENSMUST00000174287.1
ENSMUST00000173672.1
Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr3_+_90514435 0.585 ENSMUST00000048138.6
ENSMUST00000181271.1
S100a13

S100 calcium binding protein A13

chr14_-_20730327 0.578 ENSMUST00000047490.5
Ndst2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chrX_-_155216444 0.552 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr2_+_156421083 0.540 ENSMUST00000125153.2
ENSMUST00000103136.1
ENSMUST00000109577.2
Epb4.1l1


erythrocyte protein band 4.1-like 1


chr11_+_58963790 0.539 ENSMUST00000075141.6
Trim17
tripartite motif-containing 17
chr3_-_89245829 0.524 ENSMUST00000041022.8
Trim46
tripartite motif-containing 46
chr15_-_83251720 0.519 ENSMUST00000164614.1
ENSMUST00000049530.6
A4galt

alpha 1,4-galactosyltransferase

chr2_+_30266513 0.506 ENSMUST00000091132.6
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr5_+_117363513 0.481 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chrX_-_8175890 0.479 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr13_+_55600055 0.438 ENSMUST00000133176.1
ENSMUST00000064701.6
B4galt7

xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)

chr16_+_96205719 0.435 ENSMUST00000129904.1
Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr15_-_89425795 0.418 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr4_+_43641262 0.413 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2

natriuretic peptide receptor 2

chr4_-_46389391 0.402 ENSMUST00000086563.4
ENSMUST00000030015.5
5830415F09Rik

RIKEN cDNA 5830415F09 gene

chr9_+_37208291 0.401 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr16_-_38550173 0.390 ENSMUST00000036210.6
Poglut1
protein O-glucosyltransferase 1
chr15_+_78877172 0.383 ENSMUST00000041587.7
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr11_-_101119889 0.350 ENSMUST00000017946.5
Fam134c
family with sequence similarity 134, member C
chr11_-_103697898 0.285 ENSMUST00000021329.7
Gosr2
golgi SNAP receptor complex member 2
chr11_-_101119814 0.259 ENSMUST00000107295.3
Fam134c
family with sequence similarity 134, member C
chr11_+_55098104 0.248 ENSMUST00000000608.7
Gm2a
GM2 ganglioside activator protein
chr3_-_116424007 0.221 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 0.206 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr2_-_157571270 0.152 ENSMUST00000173378.1
Blcap
bladder cancer associated protein homolog (human)
chr1_+_33719863 0.130 ENSMUST00000088287.3
Rab23
RAB23, member RAS oncogene family
chr2_+_156421048 0.122 ENSMUST00000109574.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_155276297 0.114 ENSMUST00000029128.3
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr2_+_156420837 0.106 ENSMUST00000103137.3
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr3_-_39359128 0.100 ENSMUST00000056409.2
Gm9845
predicted pseudogene 9845
chr4_-_42168603 0.090 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr5_-_120777628 0.087 ENSMUST00000044833.8
Oas3
2'-5' oligoadenylate synthetase 3
chr7_-_25718976 0.079 ENSMUST00000002683.2
Ccdc97
coiled-coil domain containing 97
chr5_+_37185897 0.063 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr10_-_81600857 0.051 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr5_+_67306941 0.046 ENSMUST00000162372.1
ENSMUST00000113676.2
Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr10_+_21993890 0.039 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr12_-_111813834 0.002 ENSMUST00000021715.5
Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.7 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
1.8 7.0 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 2.1 GO:0014891 striated muscle atrophy(GO:0014891)
0.6 3.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.6 1.7 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.6 4.5 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.6 3.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 3.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 1.4 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.5 2.3 GO:0046208 spermine catabolic process(GO:0046208)
0.5 1.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.4 1.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.4 1.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 7.4 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.3 0.6 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.3 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 2.0 GO:0030242 pexophagy(GO:0030242)
0.2 0.7 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.2 0.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 1.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 1.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 9.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 0.6 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.2 0.9 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 0.7 GO:0006558 L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
0.2 1.5 GO:0006265 DNA topological change(GO:0006265)
0.2 1.6 GO:0006013 mannose metabolic process(GO:0006013)
0.2 3.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.4 GO:0016486 peptide hormone processing(GO:0016486)
0.2 1.0 GO:0002934 desmosome organization(GO:0002934)
0.2 1.6 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.2 3.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 2.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 0.8 GO:0010730 negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.1 0.5 GO:0001575 globoside metabolic process(GO:0001575)
0.1 0.7 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.6 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 1.1 GO:0007141 male meiosis I(GO:0007141)
0.1 0.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 2.2 GO:0009988 cell-cell recognition(GO:0009988)
0.1 1.3 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 2.9 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.0 0.7 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.4 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.5 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.4 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0 1.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 3.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.5 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.6 GO:0030575 nuclear body organization(GO:0030575)
0.0 1.9 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.3 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 0.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 3.3 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.4 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.1 GO:0006968 cellular defense response(GO:0006968)
0.0 0.4 GO:1901998 toxin transport(GO:1901998)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 2.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 1.0 GO:0097447 dendritic tree(GO:0097447)
0.2 1.3 GO:0008091 spectrin(GO:0008091)
0.2 2.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.0 GO:0001533 cornified envelope(GO:0001533)
0.2 0.8 GO:0045098 type III intermediate filament(GO:0045098)
0.1 3.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.5 GO:1990769 proximal neuron projection(GO:1990769)
0.1 1.8 GO:0043196 varicosity(GO:0043196)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 3.6 GO:0030673 axolemma(GO:0030673)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.0 3.4 GO:0005776 autophagosome(GO:0005776)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.0 GO:0005814 centriole(GO:0005814)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.2 GO:0030141 secretory granule(GO:0030141)
0.0 0.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.6 GO:0030426 growth cone(GO:0030426)
0.0 0.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
2.3 7.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.9 3.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.6 3.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 1.4 GO:0071723 lipopeptide binding(GO:0071723)
0.4 1.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.4 1.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.4 1.1 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.3 1.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 2.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.3 1.6 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.3 1.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.3 1.4 GO:0070330 aromatase activity(GO:0070330)
0.2 1.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 0.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 2.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 1.7 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 1.6 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 9.6 GO:0019905 syntaxin binding(GO:0019905)
0.1 3.7 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 4.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.4 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.7 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.3 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.8 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 3.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.4 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.0 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)
0.0 3.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 16.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 2.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 2.6 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 1.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 2.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.2 2.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 5.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.5 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 2.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.6 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 3.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.0 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors