Motif ID: Nr1h2

Z-value: 0.965


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.482.0e-04Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 11.699 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 7.421 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr16_-_37384915 5.692 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr10_-_109823585 5.021 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr11_-_60210410 4.541 ENSMUST00000144942.1
Srebf1
sterol regulatory element binding transcription factor 1
chr5_-_124327883 4.093 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr11_+_84179792 3.934 ENSMUST00000137500.2
ENSMUST00000130012.2
Acaca

acetyl-Coenzyme A carboxylase alpha

chr16_-_37384940 3.899 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr13_+_44729794 3.728 ENSMUST00000172830.1
Jarid2
jumonji, AT rich interactive domain 2
chr3_-_148989316 3.653 ENSMUST00000098518.2
Lphn2
latrophilin 2
chr2_+_102658640 3.636 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_+_79895017 3.483 ENSMUST00000023054.7
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr2_-_113829069 3.409 ENSMUST00000024005.7
Scg5
secretogranin V
chr13_-_12461432 3.363 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
Lgals8



lectin, galactose binding, soluble 8



chr8_-_84773381 3.151 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr11_+_84179852 3.109 ENSMUST00000136463.2
Acaca
acetyl-Coenzyme A carboxylase alpha
chr3_+_62419668 3.105 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr7_+_114768736 2.922 ENSMUST00000117543.1
Insc
inscuteable homolog (Drosophila)
chr5_+_76840597 2.767 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
C530008M17Rik


RIKEN cDNA C530008M17 gene


chr5_+_123015010 2.619 ENSMUST00000121652.1
ENSMUST00000051016.4
Orai1

ORAI calcium release-activated calcium modulator 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 11.7 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.2 9.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.3 7.4 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.8 7.0 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.6 4.5 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.3 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 3.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.5 3.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.6 3.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.6 3.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 3.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 3.3 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 3.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 2.9 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.1 2.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.5 2.3 GO:0046208 spermine catabolic process(GO:0046208)
0.0 2.3 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 2.2 GO:0009988 cell-cell recognition(GO:0009988)
0.7 2.1 GO:0014891 striated muscle atrophy(GO:0014891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.1 3.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.6 GO:0030673 axolemma(GO:0030673)
0.0 3.4 GO:0005776 autophagosome(GO:0005776)
0.0 3.2 GO:0030141 secretory granule(GO:0030141)
0.0 3.0 GO:0005814 centriole(GO:0005814)
0.0 2.6 GO:0030426 growth cone(GO:0030426)
0.3 2.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 2.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.8 GO:0043196 varicosity(GO:0043196)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.5 GO:0000793 condensed chromosome(GO:0000793)
0.2 1.3 GO:0008091 spectrin(GO:0008091)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.3 1.0 GO:0097447 dendritic tree(GO:0097447)
0.2 1.0 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.7 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 9.6 GO:0019905 syntaxin binding(GO:0019905)
2.3 7.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 4.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 3.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 3.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.6 3.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 3.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 3.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.7 GO:0043130 ubiquitin binding(GO:0043130)
0.2 2.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 2.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.0 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)
0.4 1.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 1.7 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.3 2.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 5.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.5 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 3.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.4 2.6 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 2.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.6 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 1.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle