Motif ID: Nr1h2
Z-value: 0.965

Transcription factors associated with Nr1h2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr1h2 | ENSMUSG00000060601.6 | Nr1h2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr1h2 | mm10_v2_chr7_-_44553901_44553955 | 0.48 | 2.0e-04 | Click! |
Top targets:
Showing 1 to 20 of 127 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 61 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 11.7 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
0.2 | 9.6 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
0.3 | 7.4 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
1.8 | 7.0 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
0.6 | 4.5 | GO:0003062 | regulation of heart rate by chemical signal(GO:0003062) |
0.3 | 3.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 3.7 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
0.5 | 3.6 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.6 | 3.5 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
0.6 | 3.4 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.2 | 3.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 3.3 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
0.2 | 3.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.2 | 3.1 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.1 | 2.9 | GO:0060487 | lung epithelial cell differentiation(GO:0060487) |
0.1 | 2.6 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.5 | 2.3 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.0 | 2.3 | GO:0006073 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
0.1 | 2.2 | GO:0009988 | cell-cell recognition(GO:0009988) |
0.7 | 2.1 | GO:0014891 | striated muscle atrophy(GO:0014891) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 28 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 11.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 6.0 | GO:0001650 | fibrillar center(GO:0001650) |
0.1 | 3.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 3.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.1 | 3.6 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 3.4 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 3.2 | GO:0030141 | secretory granule(GO:0030141) |
0.0 | 3.0 | GO:0005814 | centriole(GO:0005814) |
0.0 | 2.6 | GO:0030426 | growth cone(GO:0030426) |
0.3 | 2.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.4 | 2.1 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.2 | 2.0 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.1 | 1.8 | GO:0043196 | varicosity(GO:0043196) |
0.0 | 1.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 1.5 | GO:0000793 | condensed chromosome(GO:0000793) |
0.2 | 1.3 | GO:0008091 | spectrin(GO:0008091) |
0.1 | 1.3 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 1.1 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.3 | 1.0 | GO:0097447 | dendritic tree(GO:0097447) |
0.2 | 1.0 | GO:0001533 | cornified envelope(GO:0001533) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 53 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.7 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.1 | 9.6 | GO:0019905 | syntaxin binding(GO:0019905) |
2.3 | 7.0 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
0.1 | 4.5 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.1 | 3.7 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 3.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.6 | 3.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.9 | 3.5 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
0.0 | 3.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
0.0 | 2.7 | GO:0043130 | ubiquitin binding(GO:0043130) |
0.2 | 2.6 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.3 | 2.3 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.2 | 2.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
0.0 | 2.0 | GO:0032947 | protein complex scaffold(GO:0032947) |
0.0 | 2.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.1 | 1.8 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
0.0 | 1.8 | GO:0005262 | calcium channel activity(GO:0005262) |
0.4 | 1.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.2 | 1.7 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
0.0 | 1.7 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in C2:CP category:
Showing 1 to 13 of 13 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 16.2 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 3.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 3.1 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
0.1 | 3.0 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 2.6 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
0.3 | 2.1 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.1 | 1.6 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.0 | 1.6 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 1.4 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
0.0 | 1.2 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.4 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 20 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 11.7 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 5.0 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
0.1 | 4.5 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
0.1 | 3.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.2 | 2.7 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
0.4 | 2.6 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.1 | 2.3 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.1 | 2.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.2 | 2.1 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.1 | 1.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.1 | 1.6 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
0.0 | 1.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.2 | 1.4 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.1 | 1.3 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.0 | 1.3 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 1.0 | REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM | Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism |
0.0 | 0.9 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
0.0 | 0.7 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.0 | 0.4 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
0.0 | 0.4 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |