Motif ID: Nr1h4

Z-value: 0.617


Transcription factors associated with Nr1h4:

Gene SymbolEntrez IDGene Name
Nr1h4 ENSMUSG00000047638.9 Nr1h4



Activity profile for motif Nr1h4.

activity profile for motif Nr1h4


Sorted Z-values histogram for motif Nr1h4

Sorted Z-values for motif Nr1h4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h4

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 4.123 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr10_+_13966268 3.402 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_42916647 3.302 ENSMUST00000132173.1
ENSMUST00000107975.1
 N28178

expressed sequence N28178

chr15_+_80287234 3.045 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr4_+_42917234 2.751 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr7_+_19176416 2.635 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr7_-_99695809 2.435 ENSMUST00000107086.2
 Slco2b1
solute carrier organic anion transporter family, member 2b1
chrX_+_73064787 2.282 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chr10_-_33995054 2.174 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chr6_-_124769548 2.159 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr4_+_53440388 2.145 ENSMUST00000102911.3
ENSMUST00000107646.2
 Slc44a1

solute carrier family 44, member 1

chr19_+_6400523 2.083 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr5_-_147725988 1.996 ENSMUST00000110529.1
ENSMUST00000031652.3
ENSMUST00000031653.5
 Flt1


FMS-like tyrosine kinase 1


chr7_-_44670820 1.891 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr1_+_75507077 1.888 ENSMUST00000037330.4
 Inha
inhibin alpha
chr2_-_152951547 1.618 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr19_+_44992127 1.603 ENSMUST00000179305.1
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_+_117849361 1.541 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_74590065 1.500 ENSMUST00000145524.1
ENSMUST00000047488.7
 Rap1gap2

RAP1 GTPase activating protein 2

chr7_-_105482197 1.484 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.1 GO:0007021 tubulin complex assembly(GO:0007021)
1.0 3.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 3.0 GO:0030431 sleep(GO:0030431)
0.0 3.0 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 2.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.4 2.6 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 2.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 2.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 2.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.4 2.1 GO:0015871 choline transport(GO:0015871)
0.3 2.0 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.6 1.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.3 1.9 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.1 1.9 GO:0071625 vocalization behavior(GO:0071625)
0.0 1.6 GO:0050919 negative chemotaxis(GO:0050919)
0.2 1.4 GO:0006172 ADP biosynthetic process(GO:0006172)
0.3 1.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 1.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.3 1.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 1.1 GO:2001025 positive regulation of response to drug(GO:2001025)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.1 GO:0097512 cardiac myofibril(GO:0097512)
0.0 3.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 1.9 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.4 1.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 1.9 GO:0097513 myosin II filament(GO:0097513)
0.2 1.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.1 1.0 GO:0033269 internode region of axon(GO:0033269)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.8 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.7 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.7 GO:0030123 AP-3 adaptor complex(GO:0030123) HOPS complex(GO:0030897)
0.0 0.7 GO:0012505 endomembrane system(GO:0012505)
0.2 0.6 GO:0045160 myosin I complex(GO:0045160)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 3.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 3.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 3.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 2.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 2.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 2.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 2.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 2.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 2.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 1.9 GO:0034711 inhibin binding(GO:0034711)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.0 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 2.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 2.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 2.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.1 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 2.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.5 1.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)