Motif ID: Nr1i2
Z-value: 0.760
Transcription factors associated with Nr1i2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr1i2 | ENSMUSG00000022809.4 | Nr1i2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 195 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 1.7 | 5.0 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.5 | 4.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.2 | 3.7 | GO:0035622 | intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705) |
| 0.1 | 3.1 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 1.0 | 3.0 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 3.0 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.9 | 2.6 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 0.2 | 2.5 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.1 | 2.5 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.1 | 2.4 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.7 | 2.2 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.3 | 2.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.2 | 2.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 2.0 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 2.0 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.6 | 1.9 | GO:0010752 | negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.4 | 1.9 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 1.9 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) |
| 0.3 | 1.9 | GO:0089700 | protein kinase D signaling(GO:0089700) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 75 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 5.4 | GO:0043235 | receptor complex(GO:0043235) |
| 0.2 | 4.7 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 4.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 2.6 | GO:0005903 | brush border(GO:0005903) |
| 0.6 | 2.5 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.2 | 2.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 2.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.6 | 1.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.9 | GO:0030118 | clathrin coat(GO:0030118) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.1 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 130 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 4.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 3.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 3.3 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.1 | 3.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.7 | 3.0 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.5 | 2.6 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.4 | 2.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 2.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 2.4 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.7 | 2.2 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.6 | 2.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 2.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 2.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 2.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 2.0 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 2.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.6 | 1.9 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 1.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 1.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 3.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.2 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 2.1 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.2 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.1 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.0 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.0 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.0 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.9 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.9 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.5 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 57 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.8 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.3 | 3.7 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 3.0 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 2.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.6 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.5 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 2.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 2.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.0 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.5 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.3 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.2 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 1.0 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 1.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
