Motif ID: Nr1i3
Z-value: 1.486
Transcription factors associated with Nr1i3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr1i3 | ENSMUSG00000005677.8 | Nr1i3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1i3 | mm10_v2_chr1_+_171213969_171214007 | -0.08 | 5.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 624 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 33.2 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 8.3 | 24.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.3 | 20.2 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 1.0 | 17.8 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.6 | 16.9 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 1.4 | 14.9 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.4 | 14.5 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.7 | 14.4 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 2.8 | 13.8 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.4 | 13.2 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 1.5 | 13.1 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 4.3 | 12.8 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.4 | 12.7 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 1.8 | 12.6 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.6 | 12.2 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 1.1 | 10.5 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.3 | 10.2 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 2.4 | 9.7 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.3 | 9.7 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.3 | 9.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 256 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.6 | 39.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.5 | 28.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 26.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 26.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 25.8 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 25.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 4.2 | 24.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.6 | 21.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.4 | 20.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 19.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 17.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 16.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 14.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.8 | 13.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.7 | 12.4 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.2 | 12.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 2.5 | 10.2 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 2.0 | 10.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.2 | 10.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 394 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.6 | 27.4 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 24.3 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.4 | 19.5 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.6 | 17.9 | GO:0030371 | translation repressor activity(GO:0030371) |
| 2.9 | 17.7 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.8 | 17.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.5 | 15.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.4 | 15.1 | GO:0008430 | selenium binding(GO:0008430) |
| 1.4 | 14.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.4 | 14.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 4.6 | 13.8 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 13.5 | GO:0005178 | integrin binding(GO:0005178) |
| 3.3 | 13.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.9 | 13.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.5 | 12.8 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 4.2 | 12.6 | GO:0033680 | ATP-dependent DNA/RNA helicase activity(GO:0033680) |
| 3.2 | 12.6 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 12.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 4.0 | 12.1 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 76 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.4 | 33.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 22.2 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.4 | 21.8 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 21.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 17.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.7 | 14.9 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 12.4 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 12.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 12.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.4 | 11.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.4 | 10.7 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 9.8 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.7 | 9.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 9.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 7.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 7.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 7.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 6.6 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 6.2 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 126 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 51.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 37.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.8 | 33.1 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.8 | 20.5 | REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 1.2 | 19.6 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.5 | 16.3 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 15.7 | REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 15.0 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 1.5 | 14.8 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 14.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 13.5 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 12.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 12.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.4 | 11.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.7 | 11.5 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.4 | 11.3 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 10.8 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 9.1 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 9.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 8.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
