Motif ID: Nr2c1

Z-value: 0.676


Transcription factors associated with Nr2c1:

Gene SymbolEntrez IDGene Name
Nr2c1 ENSMUSG00000005897.8 Nr2c1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_94148023-0.367.2e-03Click!


Activity profile for motif Nr2c1.

activity profile for motif Nr2c1


Sorted Z-values histogram for motif Nr2c1

Sorted Z-values for motif Nr2c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_80091320 6.519 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr9_-_29411736 6.409 ENSMUST00000115236.1
 Ntm
neurotrimin
chr9_-_29412204 6.029 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_-_46991842 5.756 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_-_21037775 5.189 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr15_+_3270767 4.736 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr10_+_58813359 4.475 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr10_-_86498836 4.300 ENSMUST00000120638.1
 Syn3
synapsin III
chr11_+_75193783 3.966 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr1_-_155417283 3.900 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr12_-_83487708 3.810 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr6_+_22875496 3.790 ENSMUST00000090568.3
 Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr11_-_76577701 3.666 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr7_+_45896941 3.493 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr3_+_68572245 3.331 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr12_+_61523889 3.244 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr6_-_142964404 2.622 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr2_-_29253001 2.500 ENSMUST00000071201.4
 Ntng2
netrin G2
chr4_-_129440800 2.457 ENSMUST00000053042.5
ENSMUST00000106046.1
 Zbtb8b

zinc finger and BTB domain containing 8b

chr7_+_45897429 2.327 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 6.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.3 6.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 5.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 4.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
1.4 4.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.6 3.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.3 3.8 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.7 3.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.2 3.6 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 3.5 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.2 3.3 GO:0001553 luteinization(GO:0001553)
0.1 2.6 GO:0034605 cellular response to heat(GO:0034605)
0.1 2.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 2.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 2.0 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.4 1.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.3 1.8 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1 1.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.4 1.7 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 12.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 6.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.2 5.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 4.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 4.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.3 3.8 GO:0072534 perineuronal net(GO:0072534)
0.2 3.8 GO:0071565 nBAF complex(GO:0071565)
0.4 3.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.1 GO:0030673 axolemma(GO:0030673)
0.0 2.0 GO:0016235 aggresome(GO:0016235)
0.0 1.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.4 GO:0014704 intercalated disc(GO:0014704)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.3 1.3 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 1.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.7 4.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 4.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
1.3 3.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 3.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 2.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 1.8 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.6 1.8 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 1.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 1.0 GO:0004103 choline kinase activity(GO:0004103)
0.1 1.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 2.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 0.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.4 5.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.0 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.8 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE