Motif ID: Nr2c2

Z-value: 1.142


Transcription factors associated with Nr2c2:

Gene SymbolEntrez IDGene Name
Nr2c2 ENSMUSG00000005893.8 Nr2c2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c2mm10_v2_chr6_+_92091378_92091390-0.671.9e-08Click!


Activity profile for motif Nr2c2.

activity profile for motif Nr2c2


Sorted Z-values histogram for motif Nr2c2

Sorted Z-values for motif Nr2c2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_120120138 13.635 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr4_-_97778042 10.741 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr13_-_24761861 10.212 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr10_-_88146867 9.485 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr7_+_79500081 9.266 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr7_+_79500018 9.143 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr11_+_61485431 8.966 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr1_-_133424377 8.752 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr14_-_52020698 8.209 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr6_-_95718800 7.589 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr1_-_172219715 7.388 ENSMUST00000170700.1
ENSMUST00000003554.4
 Casq1

calsequestrin 1

chr1_+_191821444 7.333 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr17_+_35049966 7.141 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr14_+_65806066 7.082 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr8_+_88521344 6.787 ENSMUST00000034086.5
 Nkd1
naked cuticle 1 homolog (Drosophila)
chr1_-_138847579 6.627 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr17_-_56830916 6.624 ENSMUST00000002444.7
ENSMUST00000086801.5
 Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr18_-_74207771 6.407 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr2_+_118598209 6.393 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr17_+_56303321 6.388 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 19.4 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
2.3 16.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
5.3 15.8 GO:0030421 defecation(GO:0030421)
0.2 13.3 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.9 12.1 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.2 9.8 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.0 9.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.8 8.8 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.9 8.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.0 7.8 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.8 7.6 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
2.5 7.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 7.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.8 7.3 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.5 7.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.2 7.1 GO:1902476 chloride transmembrane transport(GO:1902476)
1.7 6.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 6.5 GO:0051028 mRNA transport(GO:0051028)
2.1 6.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.3 6.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.7 19.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 17.5 GO:0005667 transcription factor complex(GO:0005667)
0.3 17.0 GO:0000791 euchromatin(GO:0000791)
1.1 12.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.0 10.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 9.5 GO:0005875 microtubule associated complex(GO:0005875)
3.0 9.0 GO:0071953 elastic fiber(GO:0071953)
0.4 8.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 7.5 GO:0034707 chloride channel complex(GO:0034707)
0.2 7.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.8 7.4 GO:0014802 terminal cisterna(GO:0014802)
0.1 7.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
1.1 6.9 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 6.8 GO:0005681 spliceosomal complex(GO:0005681)
0.3 6.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.0 6.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 6.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 5.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 5.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.5 19.4 GO:0030156 benzodiazepine receptor binding(GO:0030156)
3.0 12.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 11.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 11.6 GO:0004386 helicase activity(GO:0004386)
0.1 11.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 10.9 GO:0003677 DNA binding(GO:0003677)
0.0 10.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 9.9 GO:0008083 growth factor activity(GO:0008083)
0.1 9.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 8.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 8.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
2.5 7.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.1 7.5 GO:0005254 chloride channel activity(GO:0005254)
0.3 6.5 GO:0008327 methyl-CpG binding(GO:0008327)
1.2 6.2 GO:0032027 myosin light chain binding(GO:0032027)
0.2 6.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 6.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.5 5.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.9 5.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 5.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 12.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 9.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 8.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 8.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 7.4 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.9 PID_BARD1_PATHWAY BARD1 signaling events
0.1 4.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 4.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 3.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 3.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.0 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 19.7 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.9 11.8 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 11.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 10.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.4 7.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 5.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 5.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 5.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 4.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 4.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 4.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 3.4 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 3.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.6 3.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 3.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 3.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 3.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 3.0 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis