Motif ID: Nr2e1

Z-value: 0.391


Transcription factors associated with Nr2e1:

Gene SymbolEntrez IDGene Name
Nr2e1 ENSMUSG00000019803.5 Nr2e1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2e1mm10_v2_chr10_-_42583628_42583639-0.482.0e-04Click!


Activity profile for motif Nr2e1.

activity profile for motif Nr2e1


Sorted Z-values histogram for motif Nr2e1

Sorted Z-values for motif Nr2e1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_33924632 1.572 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chr8_+_36489191 1.124 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr4_-_35845204 1.110 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chrX_-_95658379 1.052 ENSMUST00000119640.1
 Zc4h2
zinc finger, C4H2 domain containing
chrX_-_95658392 1.021 ENSMUST00000120620.1
 Zc4h2
zinc finger, C4H2 domain containing
chr4_+_32238950 0.943 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr3_+_26331150 0.932 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chrX_-_95658416 0.921 ENSMUST00000044382.6
 Zc4h2
zinc finger, C4H2 domain containing
chr7_+_114768736 0.899 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chr14_+_32028989 0.827 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr4_-_119415494 0.752 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr9_-_58158498 0.684 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr4_+_28813125 0.630 ENSMUST00000029964.5
ENSMUST00000080934.4
 Epha7

Eph receptor A7

chr4_+_28813152 0.524 ENSMUST00000108194.2
ENSMUST00000108191.1
 Epha7

Eph receptor A7

chr2_-_73386396 0.493 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr10_+_18469958 0.477 ENSMUST00000162891.1
ENSMUST00000100054.3
 Nhsl1

NHS-like 1

chr7_+_78895903 0.463 ENSMUST00000107425.1
ENSMUST00000107421.1
ENSMUST00000107423.1
 Aen


apoptosis enhancing nuclease


chr15_-_10485385 0.429 ENSMUST00000168690.1
 Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr1_-_132390301 0.377 ENSMUST00000132435.1
 Tmcc2
transmembrane and coiled-coil domains 2
chr18_+_34840575 0.376 ENSMUST00000043484.7
 Reep2
receptor accessory protein 2
chr3_-_146781351 0.373 ENSMUST00000005164.7
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr6_+_126939957 0.366 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chrX_-_143827391 0.295 ENSMUST00000087316.5
 Capn6
calpain 6
chr15_+_41830921 0.277 ENSMUST00000166917.1
 Oxr1
oxidation resistance 1
chr2_-_23040137 0.270 ENSMUST00000091394.6
ENSMUST00000093171.6
 Abi1

abl-interactor 1

chr2_-_23040177 0.245 ENSMUST00000114544.3
ENSMUST00000139038.1
ENSMUST00000126112.1
ENSMUST00000178908.1
ENSMUST00000078977.7
ENSMUST00000140164.1
ENSMUST00000149719.1
 Abi1






abl-interactor 1






chr10_-_61784014 0.240 ENSMUST00000020283.4
 H2afy2
H2A histone family, member Y2
chrX_-_139998519 0.234 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
 Rbm41



RNA binding motif protein 41



chr2_-_23040092 0.230 ENSMUST00000153931.1
ENSMUST00000123948.1
 Abi1

abl-interactor 1

chr15_-_97705787 0.168 ENSMUST00000023104.5
 Rpap3
RNA polymerase II associated protein 3
chr14_-_54517353 0.161 ENSMUST00000023873.5
 Prmt5
protein arginine N-methyltransferase 5
chr18_+_36793918 0.158 ENSMUST00000001419.8
 Zmat2
zinc finger, matrin type 2
chr9_-_71163224 0.133 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr4_-_63403330 0.107 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr15_-_10485890 0.104 ENSMUST00000169050.1
ENSMUST00000022855.5
 Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr15_+_10486008 0.089 ENSMUST00000022856.8
ENSMUST00000100775.3
ENSMUST00000169519.1
 Rad1


RAD1 homolog (S. pombe)


chr12_+_111166485 0.082 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3
chr9_-_42457594 0.057 ENSMUST00000125995.1
 Tbcel
tubulin folding cofactor E-like
chr7_+_131542867 0.036 ENSMUST00000046093.5
 Hmx3
H6 homeobox 3
chr1_+_24678536 0.016 ENSMUST00000095062.3
 Lmbrd1
LMBR1 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0031622 positive regulation of fever generation(GO:0031622) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 1.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.4 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.0 0.5 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.9 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.4 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 4.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0008144 drug binding(GO:0008144)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.6 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)