Motif ID: Nr2e3

Z-value: 0.714


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_35215008 9.036 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr6_-_13839916 7.293 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr2_+_65620829 5.862 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr4_-_138396438 5.737 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr10_-_109764840 5.242 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr6_+_141524379 4.685 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr10_-_109010955 4.621 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr11_-_42182924 4.062 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr3_+_54156039 3.985 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr10_-_109009055 3.736 ENSMUST00000156979.1
 Syt1
synaptotagmin I
chr11_+_111066154 3.711 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr18_+_32938955 3.643 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr1_+_19103022 3.489 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr13_-_51701041 3.460 ENSMUST00000110042.1
 Gm15440
predicted gene 15440
chr2_-_45112890 3.445 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr4_-_151861698 3.431 ENSMUST00000049790.7
 Camta1
calmodulin binding transcription activator 1
chr4_-_151861762 3.370 ENSMUST00000097774.2
 Camta1
calmodulin binding transcription activator 1
chr3_+_68468162 3.219 ENSMUST00000182532.1
 Schip1
schwannomin interacting protein 1
chr14_+_101840602 3.212 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr1_+_143640664 3.145 ENSMUST00000038252.2
 B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 9.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.1 8.6 GO:0005513 detection of calcium ion(GO:0005513)
1.0 8.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 8.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.4 5.5 GO:0006710 androgen catabolic process(GO:0006710)
0.6 5.4 GO:0071420 cellular response to histamine(GO:0071420)
0.4 5.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 5.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 5.0 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.4 4.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 4.0 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 3.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 3.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 3.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.5 3.7 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.2 3.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.6 3.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 3.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 3.2 GO:0001553 luteinization(GO:0001553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 8.4 GO:0031045 dense core granule(GO:0031045)
0.0 8.3 GO:0005730 nucleolus(GO:0005730)
0.9 8.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 5.5 GO:0005811 lipid particle(GO:0005811)
0.0 5.5 GO:0030426 growth cone(GO:0030426)
0.4 5.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 5.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.0 GO:0005635 nuclear envelope(GO:0005635)
0.0 4.8 GO:0016605 PML body(GO:0016605)
0.1 4.0 GO:0034704 calcium channel complex(GO:0034704)
0.3 3.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 3.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 3.0 GO:0044295 axonal growth cone(GO:0044295)
0.7 2.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.7 2.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 2.7 GO:0005638 lamin filament(GO:0005638)
0.3 2.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 1.9 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 9.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 9.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.1 8.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 8.4 GO:0008017 microtubule binding(GO:0008017)
1.4 8.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 7.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.8 5.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3 5.5 GO:0045499 chemorepellent activity(GO:0045499)
0.9 5.4 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.2 4.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 4.5 GO:0042805 actinin binding(GO:0042805)
0.1 3.9 GO:0070412 R-SMAD binding(GO:0070412)
0.5 3.7 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 3.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 3.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.8 3.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 3.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 2.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 2.8 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 5.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 8.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 5.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.6 4.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.4 4.0 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 4.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 3.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.4 2.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.1 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.1 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)