Motif ID: Nr2f1_Nr4a1

Z-value: 0.943

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.551.2e-05Click!
Nr2f1mm10_v2_chr13_-_78197815_781979300.143.2e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_57142782 8.925 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr4_+_154960915 8.230 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr9_-_119578981 8.218 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr9_-_54661666 6.294 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_+_166254095 5.694 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr6_-_76497631 4.820 ENSMUST00000097218.5
 Gm9008
predicted pseudogene 9008
chr12_-_111672290 4.706 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr1_+_191821444 4.675 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr12_-_110978981 4.602 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9


chr4_-_41697040 4.324 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr3_-_138131356 4.258 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr11_-_100822525 4.255 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr10_+_4611971 4.212 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr3_+_146500071 4.210 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr13_+_21722057 4.170 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr5_+_111581422 4.012 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr13_-_48273865 3.842 ENSMUST00000180777.1
 A330048O09Rik
RIKEN cDNA A330048O09 gene
chr7_-_109616548 3.757 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr1_-_172206775 3.559 ENSMUST00000013842.5
ENSMUST00000111247.1
 Pea15a

phosphoprotein enriched in astrocytes 15A

chr7_-_4522427 3.553 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 289 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 9.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 9.6 GO:0051384 response to glucocorticoid(GO:0051384)
2.7 8.2 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
2.1 8.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.3 8.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 7.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 6.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 6.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
1.0 6.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.0 5.9 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 5.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.2 5.6 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.5 5.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 5.4 GO:0014003 oligodendrocyte development(GO:0014003)
1.2 5.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.2 4.7 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.8 4.7 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
1.5 4.6 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.9 4.6 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.7 4.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 12.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 8.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 7.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 7.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 7.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 6.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
2.0 6.1 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.5 5.9 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 5.8 GO:0001891 phagocytic cup(GO:0001891)
0.3 5.5 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
1.8 5.4 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.1 4.7 GO:0000786 nucleosome(GO:0000786)
0.4 4.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 4.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.4 4.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.1 4.2 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.6 4.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 10.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.3 8.9 GO:0001849 complement component C1q binding(GO:0001849)
0.4 8.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.1 7.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 7.5 GO:0005109 frizzled binding(GO:0005109)
2.0 5.9 GO:0030172 troponin C binding(GO:0030172)
0.1 5.8 GO:0005080 protein kinase C binding(GO:0005080)
0.4 5.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.4 5.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 5.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 5.3 GO:0051082 unfolded protein binding(GO:0051082)
1.0 5.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.6 4.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.5 4.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.5 4.6 GO:0031403 lithium ion binding(GO:0031403)
0.1 4.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 4.3 GO:0009055 electron carrier activity(GO:0009055)
1.4 4.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.4 4.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 12.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 7.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 6.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 4.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 2.9 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.6 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 2.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 30.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 15.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 8.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 8.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 8.0 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 6.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 6.6 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 6.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 5.8 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 5.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.7 5.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4 4.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 4.7 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.3 4.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 3.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 3.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression