Motif ID: Nr3c2

Z-value: 0.663


Transcription factors associated with Nr3c2:

Gene SymbolEntrez IDGene Name
Nr3c2 ENSMUSG00000031618.7 Nr3c2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr3c2mm10_v2_chr8_+_76902277_76902476-0.367.1e-03Click!


Activity profile for motif Nr3c2.

activity profile for motif Nr3c2


Sorted Z-values histogram for motif Nr3c2

Sorted Z-values for motif Nr3c2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr3c2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_6882068 13.453 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr8_+_94179089 8.658 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr9_+_123366921 8.631 ENSMUST00000038863.7
 Lars2
leucyl-tRNA synthetase, mitochondrial
chr3_-_95904683 7.795 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr8_+_71406003 5.992 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr4_-_149137536 4.551 ENSMUST00000176124.1
ENSMUST00000177408.1
ENSMUST00000105695.1
ENSMUST00000030813.3
 Apitd1



apoptosis-inducing, TAF9-like domain 1



chr14_-_8309770 3.421 ENSMUST00000121887.1
ENSMUST00000036070.8
ENSMUST00000137133.1
 Fam107a


family with sequence similarity 107, member A


chr10_+_26822560 3.335 ENSMUST00000135866.1
 Arhgap18
Rho GTPase activating protein 18
chr2_+_172472512 2.143 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr13_+_99100698 2.068 ENSMUST00000181742.1
 Gm807
predicted gene 807
chr3_-_88739692 1.456 ENSMUST00000090946.2
 Gm10253
predicted gene 10253
chr4_-_9643638 1.338 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr1_-_171240055 1.238 ENSMUST00000131286.1
 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr5_+_112288734 1.184 ENSMUST00000151947.1
 Tpst2
protein-tyrosine sulfotransferase 2
chr5_-_31697598 1.143 ENSMUST00000031018.7
 Rbks
ribokinase
chr11_+_101448403 0.858 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr16_+_38346986 0.825 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
 Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr8_+_70697739 0.812 ENSMUST00000095267.4
 Jund
Jun proto-oncogene related gene d
chr14_+_70530819 0.806 ENSMUST00000047331.6
 Lgi3
leucine-rich repeat LGI family, member 3
chr10_-_78464853 0.612 ENSMUST00000105385.1
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr15_-_97020322 0.611 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr16_-_96192222 0.562 ENSMUST00000113804.1
ENSMUST00000054855.7
 Lca5l

Leber congenital amaurosis 5-like

chr6_-_69631933 0.544 ENSMUST00000177697.1
 Igkv4-54
immunoglobulin kappa chain variable 4-54
chr10_-_78464969 0.537 ENSMUST00000041616.8
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr14_+_66784523 0.471 ENSMUST00000071522.2
 Gm10032
predicted gene 10032
chr10_-_14718191 0.375 ENSMUST00000020016.4
 Gje1
gap junction protein, epsilon 1
chr6_-_69400097 0.246 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chr1_-_74935549 0.188 ENSMUST00000094844.3
 Ccdc108
coiled-coil domain containing 108
chr2_-_91444622 0.135 ENSMUST00000064652.7
ENSMUST00000102594.4
ENSMUST00000094835.2
 1110051M20Rik


RIKEN cDNA 1110051M20 gene


chr15_+_102102926 0.085 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0060166 olfactory pit development(GO:0060166)
1.5 6.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.2 8.7 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
1.0 7.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.8 0.8 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.4 1.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 1.2 GO:0060468 prevention of polyspermy(GO:0060468)
0.4 1.1 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.3 1.1 GO:0006014 D-ribose metabolic process(GO:0006014)
0.2 8.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.8 GO:0002076 osteoblast development(GO:0002076)
0.0 1.2 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 3.3 GO:0008360 regulation of cell shape(GO:0008360)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.8 GO:0035976 AP1 complex(GO:0035976)
0.0 12.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 7.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 4.3 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.6 8.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 13.5 GO:0071837 HMG box domain binding(GO:0071837)
0.4 1.1 GO:0031403 lithium ion binding(GO:0031403)
0.3 1.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.2 9.5 GO:0005507 copper ion binding(GO:0005507)
0.1 1.2 GO:0048038 quinone binding(GO:0048038)
0.0 6.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.3 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_P73PATHWAY p73 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 4.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import