Motif ID: Nr4a3

Z-value: 0.598


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.172.3e-01Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 5.432 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chrY_-_1245685 3.629 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr5_+_66968559 2.511 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrY_-_1245753 2.181 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr8_+_124793013 2.027 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 1.932 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_+_66968416 1.910 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr9_-_54661666 1.702 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr11_-_55033398 1.394 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr5_+_111581422 1.372 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr7_-_109616548 1.254 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr2_+_59160838 1.092 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chr15_+_25773985 1.047 ENSMUST00000125667.1
 Myo10
myosin X
chr6_-_138426735 1.017 ENSMUST00000162932.1
 Lmo3
LIM domain only 3
chr4_+_99955715 0.962 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr3_-_104818539 0.932 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr6_-_76497631 0.928 ENSMUST00000097218.5
 Gm9008
predicted pseudogene 9008
chr7_-_98162318 0.879 ENSMUST00000107112.1
 Capn5
calpain 5
chr15_-_79804717 0.825 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr19_-_4334001 0.816 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.4 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.6 4.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 4.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 3.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 1.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 1.0 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 1.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.9 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.8 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.7 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.7 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.2 0.6 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.5 GO:0010155 regulation of proton transport(GO:0010155)
0.1 0.4 GO:2000331 regulation of terminal button organization(GO:2000331)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.1 GO:0030057 desmosome(GO:0030057)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0097444 spine apparatus(GO:0097444)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 4.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 1.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 1.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 0.8 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 0.8 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.4 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling