Motif ID: Nr5a2

Z-value: 0.650


Transcription factors associated with Nr5a2:

Gene SymbolEntrez IDGene Name
Nr5a2 ENSMUSG00000026398.8 Nr5a2



Activity profile for motif Nr5a2.

activity profile for motif Nr5a2


Sorted Z-values histogram for motif Nr5a2

Sorted Z-values for motif Nr5a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr5a2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_77347816 3.075 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 2.406 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr15_-_79804717 2.312 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr8_+_124793013 2.305 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 2.269 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr2_+_121357714 2.229 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr3_-_54915867 2.056 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr9_-_77347889 1.951 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr2_+_121358591 1.850 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr19_+_6400523 1.796 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr10_+_79716588 1.726 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr11_+_67586520 1.679 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_98741805 1.650 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr19_-_57314896 1.647 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr16_+_18776839 1.597 ENSMUST00000043577.1
 Cldn5
claudin 5
chr11_+_67586675 1.570 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr11_-_4704334 1.532 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr19_-_46327121 1.509 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr1_-_134235420 1.456 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr17_-_83631892 1.446 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 4.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 3.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 3.3 GO:0030041 actin filament polymerization(GO:0030041)
0.3 3.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 2.8 GO:0009060 aerobic respiration(GO:0009060)
0.0 2.8 GO:0032091 negative regulation of protein binding(GO:0032091)
0.2 2.3 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 2.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 1.8 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.3 1.7 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.2 1.7 GO:1990845 adaptive thermogenesis(GO:1990845)
0.5 1.6 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.3 1.6 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.5 1.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.3 1.5 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0016605 PML body(GO:0016605)
0.0 5.1 GO:0044455 mitochondrial membrane part(GO:0044455)
0.0 3.2 GO:0005604 basement membrane(GO:0005604)
0.0 3.2 GO:0043209 myelin sheath(GO:0043209)
0.2 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 2.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.3 2.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 2.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.8 GO:0005884 actin filament(GO:0005884)
0.6 1.7 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.6 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 1.5 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.4 1.4 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 4.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.1 4.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 4.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 4.1 GO:0005518 collagen binding(GO:0005518)
0.2 3.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 2.3 GO:0001847 opsonin receptor activity(GO:0001847)
0.3 2.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 1.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.4 1.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.5 1.6 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.2 1.6 GO:0015288 porin activity(GO:0015288)
0.2 1.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 1.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.5 1.4 GO:0031403 lithium ion binding(GO:0031403)
0.5 1.4 GO:0030172 troponin C binding(GO:0030172)
0.4 1.4 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.4 GO:0038191 neuropilin binding(GO:0038191)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.6 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.6 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 2.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 1.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation