Motif ID: Nr5a2
Z-value: 0.650
Transcription factors associated with Nr5a2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr5a2 | ENSMUSG00000026398.8 | Nr5a2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.5 | 1.5 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.5 | 1.4 | GO:0042823 | pyridoxal phosphate biosynthetic process(GO:0042823) |
| 0.5 | 1.4 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.4 | 1.2 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.4 | 1.2 | GO:0021933 | radial glia guided migration of cerebellar granule cell(GO:0021933) |
| 0.4 | 1.4 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.3 | 1.0 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.3 | 1.0 | GO:0019043 | establishment of viral latency(GO:0019043) |
| 0.3 | 1.7 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.3 | 3.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 1.8 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.3 | 0.6 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.3 | 0.6 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.3 | 0.9 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.3 | 0.8 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.3 | 0.8 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.3 | 1.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.3 | 1.5 | GO:1902287 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.3 | 1.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 0.5 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 0.2 | 0.7 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.2 | 0.7 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.2 | 1.1 | GO:0019659 | fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.2 | 2.3 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.2 | 1.0 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.2 | 0.6 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 1.7 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 7.6 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.2 | 0.9 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.2 | 0.9 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.2 | 4.6 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
| 0.2 | 0.5 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.1 | 0.4 | GO:2000823 | regulation of androgen receptor activity(GO:2000823) |
| 0.1 | 0.3 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.1 | 0.6 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.1 | 0.4 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.1 | 0.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.1 | 0.4 | GO:1902445 | negative regulation of oxidative phosphorylation(GO:0090324) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.1 | 0.9 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.1 | 0.7 | GO:0046103 | inosine biosynthetic process(GO:0046103) |
| 0.1 | 1.2 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.1 | 0.3 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.1 | 0.4 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 0.5 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.1 | 1.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 0.3 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 0.5 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.1 | 1.6 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 0.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 0.9 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.5 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.1 | 0.5 | GO:0021539 | subthalamus development(GO:0021539) |
| 0.1 | 2.1 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 1.4 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 1.0 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.1 | 0.4 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 1.1 | GO:0018195 | peptidyl-arginine modification(GO:0018195) |
| 0.1 | 0.6 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 0.7 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.1 | 0.6 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.1 | 0.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 3.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 1.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.6 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.1 | 1.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 1.0 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 0.4 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.1 | 1.0 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.2 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
| 0.1 | 2.8 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 0.4 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 2.1 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.3 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
| 0.0 | 0.6 | GO:0060484 | male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484) |
| 0.0 | 0.5 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.3 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.0 | 0.1 | GO:0071649 | negative regulation of mitochondrial fusion(GO:0010637) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) |
| 0.0 | 0.4 | GO:0034982 | mitochondrial protein processing(GO:0034982) |
| 0.0 | 0.7 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.2 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.0 | 0.2 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.0 | 0.3 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.4 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.0 | 0.0 | GO:0051305 | chromosome movement towards spindle pole(GO:0051305) |
| 0.0 | 0.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.2 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.1 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 0.0 | 1.4 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 0.4 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.1 | GO:1901856 | negative regulation of cellular respiration(GO:1901856) |
| 0.0 | 0.5 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.0 | 0.3 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.0 | 0.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 2.8 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 0.7 | GO:2000398 | regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398) |
| 0.0 | 0.6 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.0 | GO:0060455 | negative regulation of urine volume(GO:0035811) negative regulation of gastric acid secretion(GO:0060455) |
| 0.0 | 0.3 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) |
| 0.0 | 0.1 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.6 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.6 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.0 | 0.2 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473) |
| 0.0 | 0.8 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.1 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.0 | 1.0 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.3 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.0 | 2.2 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 3.3 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.0 | 0.1 | GO:0098912 | smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) |
| 0.0 | 2.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.2 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.0 | 1.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.1 | GO:0009644 | response to high light intensity(GO:0009644) |
| 0.0 | 0.1 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.0 | 1.0 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 0.1 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.0 | 0.1 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.0 | 0.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.4 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 0.5 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.4 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.4 | 1.4 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.3 | 2.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.3 | 2.5 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.2 | 2.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 0.7 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.2 | 0.9 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.2 | 1.1 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.2 | 2.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.2 | 2.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.5 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.1 | 0.6 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 1.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.4 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 0.5 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 1.0 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 1.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 0.7 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 0.4 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.4 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.1 | 1.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.5 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.4 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.1 | 0.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 1.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 7.0 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.9 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.2 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 1.8 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.5 | GO:0038037 | G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648) |
| 0.0 | 0.1 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.0 | 0.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.4 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.1 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 5.1 | GO:0044455 | mitochondrial membrane part(GO:0044455) |
| 0.0 | 0.5 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 0.0 | 0.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 1.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 3.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 0.5 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.1 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.4 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 0.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 3.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 1.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.1 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.6 | 2.3 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.5 | 1.6 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.5 | 1.4 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.5 | 1.4 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.4 | 1.7 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.4 | 1.7 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.4 | 1.2 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.4 | 1.2 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.4 | 1.4 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.3 | 1.0 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.3 | 2.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 1.0 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.2 | 1.6 | GO:0015288 | porin activity(GO:0015288) |
| 0.2 | 4.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 1.5 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.2 | 0.8 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.2 | 1.0 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 1.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 0.6 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.2 | 3.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.2 | 0.5 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 0.4 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 0.6 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.1 | 0.6 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.1 | 0.4 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.1 | 0.5 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 1.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.7 | GO:0015651 | quaternary ammonium group transmembrane transporter activity(GO:0015651) |
| 0.1 | 0.5 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.1 | 0.9 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 0.3 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 1.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.6 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.1 | 0.2 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.1 | 1.5 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.1 | 1.3 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 0.5 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.1 | 0.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 1.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.4 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 0.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 1.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 4.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.9 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 0.4 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.1 | 1.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.7 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 1.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 0.2 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.1 | 0.2 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.1 | 0.6 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 0.2 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.0 | 1.1 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.4 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 0.6 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.2 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.0 | 5.2 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.8 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 1.1 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 1.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 0.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.9 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 4.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.9 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 0.4 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.3 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.0 | 0.1 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.0 | 0.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.3 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 2.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.4 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 0.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 0.1 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.2 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 4.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 0.6 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.1 | 1.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.6 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.3 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.2 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.4 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.2 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.0 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.6 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.1 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 1.3 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 4.8 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 2.3 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 2.2 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 8.6 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 1.5 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 0.7 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 0.9 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 0.6 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 3.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.6 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.4 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.0 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.0 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.1 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.3 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 1.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.3 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.8 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.4 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.7 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.4 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.4 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 2.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.4 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.4 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.1 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.0 | REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 0.2 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
