ISMARA results: Nr6a1

Motif ID: Nr6a1

Z-value: 0.531

Transcription factors associated with Nr6a1:

Gene Symbol	Entrez ID	Gene Name
Nr6a1	ENSMUSG00000063972.7	Nr6a1

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Nr6a1	mm10_v2_chr2_-_38926217_38926454	-0.15	2.6e-01	Click!

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Top targets:

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Showing 1 to 20 of 67 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_42245907	4.216	ENSMUST00000031897.5	Gstk1	glutathione S-transferase kappa 1
chr13_-_24761440	3.810	ENSMUST00000176890.1 ENSMUST00000175689.1	Gmnn	geminin
chr14_+_12189943	3.550	ENSMUST00000119888.1	Ptprg	protein tyrosine phosphatase, receptor type, G
chr9_-_96437434	2.893	ENSMUST00000070500.2	BC043934	cDNA sequence BC043934
chr2_+_172472512	2.825	ENSMUST00000029007.2	Fam209	family with sequence similarity 209
chr17_+_72918298	2.783	ENSMUST00000024857.6	Lbh	limb-bud and heart
chr4_-_45530330	2.769	ENSMUST00000061986.5	Shb	src homology 2 domain-containing transforming protein B
chr19_+_46707443	2.648	ENSMUST00000003655.7	As3mt	arsenic (+3 oxidation state) methyltransferase
chr1_-_79858627	2.618	ENSMUST00000027467.4	Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2
chr6_+_83349446	2.548	ENSMUST00000136501.1	Bola3	bolA-like 3 (E. coli)
chr5_-_5694024	2.228	ENSMUST00000115425.2 ENSMUST00000115427.1 ENSMUST00000115424.2 ENSMUST00000015797.4	Steap2	six transmembrane epithelial antigen of prostate 2
chr12_+_3807017	2.173	ENSMUST00000020991.8 ENSMUST00000172509.1	Dnmt3a	DNA methyltransferase 3A
chr7_+_30314810	1.990	ENSMUST00000054594.8 ENSMUST00000177078.1 ENSMUST00000176504.1 ENSMUST00000176304.1	Syne4	spectrin repeat containing, nuclear envelope family member 4
chr5_-_30073554	1.884	ENSMUST00000026846.6	Tyms	thymidylate synthase
chr12_+_3807076	1.860	ENSMUST00000174817.1	Dnmt3a	DNA methyltransferase 3A
chr7_-_66427469	1.742	ENSMUST00000015278.7	Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3
chr17_-_46645128	1.733	ENSMUST00000003642.6	Klc4	kinesin light chain 4
chr18_-_77767752	1.674	ENSMUST00000048192.7	Haus1	HAUS augmin-like complex, subunit 1
chr7_-_145283915	1.538	ENSMUST00000058022.4	Tpcn2	two pore segment channel 2
chr5_-_5694559	1.512	ENSMUST00000115426.2	Steap2	six transmembrane epithelial antigen of prostate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 35 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	GO:0006749	glutathione metabolic process(GO:0006749)
0.5	4.0	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.1	3.8	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.7	3.7	GO:0098706	ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1	3.5	GO:1901998	toxin transport(GO:1901998)
0.8	3.2	GO:0046073	dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.3	3.0	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.6	2.8	GO:1904672	regulation of somatic stem cell population maintenance(GO:1904672)
0.7	2.6	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.2	2.6	GO:0009404	toxin metabolic process(GO:0009404)
0.0	2.3	GO:0051225	spindle assembly(GO:0051225)
0.2	2.0	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.6	1.7	GO:0060166	olfactory pit development(GO:0060166)
0.0	1.5	GO:0086010	membrane depolarization during action potential(GO:0086010)
0.0	1.3	GO:0006270	DNA replication initiation(GO:0006270)
0.3	1.2	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	1.0	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.0	1.0	GO:0003341	cilium movement(GO:0003341)
0.1	0.9	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
0.0	0.9	GO:0006958	complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 24 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	4.0	GO:0001741	XY body(GO:0001741)
0.1	3.7	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	2.8	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	2.6	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	2.0	GO:0044453	nuclear membrane part(GO:0044453)
0.2	1.7	GO:0070652	HAUS complex(GO:0070652)
0.0	1.7	GO:0005871	kinesin complex(GO:0005871)
0.1	1.3	GO:0042555	MCM complex(GO:0042555)
0.1	1.2	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1	1.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	1.0	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	1.0	GO:0030286	dynein complex(GO:0030286)
0.1	0.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.8	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.7	GO:0045179	apical cortex(GO:0045179)
0.0	0.7	GO:0002102	podosome(GO:0002102)
0.0	0.7	GO:0005811	lipid particle(GO:0005811)
0.2	0.6	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1	0.6	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.2	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.5	4.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	3.8	GO:0070491	repressing transcription factor binding(GO:0070491)
1.2	3.7	GO:0008823	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	3.5	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	2.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	2.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.6	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.1	1.9	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.4	1.7	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	1.7	GO:0003777	microtubule motor activity(GO:0003777)
0.4	1.5	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.5	1.4	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.1	1.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.2	1.2	GO:0043532	angiostatin binding(GO:0043532)
0.2	1.1	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.2	1.0	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1	1.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	1.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	0.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in C2:CP category:

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Showing 1 to 7 of 7 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	PID_MYC_REPRESS_PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	2.8	PID_PDGFRA_PATHWAY	PDGFR-alpha signaling pathway
0.0	2.6	NABA_ECM_REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.9	PID_E2F_PATHWAY	E2F transcription factor network
0.0	1.9	PID_MYC_ACTIV_PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.9	PID_P38_MKK3_6PATHWAY	p38 MAPK signaling pathway
0.0	0.7	PID_EPHA2_FWD_PATHWAY	EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.8	REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	1.9	REACTOME_G1_S_SPECIFIC_TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	1.7	REACTOME_KINESINS	Genes involved in Kinesins
0.1	1.3	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
0.1	1.2	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.8	REACTOME_COLLAGEN_FORMATION	Genes involved in Collagen formation
0.1	0.7	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.7	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.6	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.5	REACTOME_MTORC1_MEDIATED_SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.3	REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION	Genes involved in FGFR4 ligand binding and activation