Motif ID: Nrf1

Z-value: 2.830


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.359.3e-03Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_88751649 11.269 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr10_+_79682304 10.690 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr2_+_168081004 9.048 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr4_+_8690399 8.496 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr10_+_79682169 7.581 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr4_+_59581563 7.068 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr13_-_53286052 7.064 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr4_+_59581645 6.949 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr2_-_172370506 6.914 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr5_+_36484578 6.901 ENSMUST00000060100.1
 Ccdc96
coiled-coil domain containing 96
chr11_+_86544982 6.517 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr6_+_66535390 6.511 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr6_+_66535418 6.212 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr14_+_59625281 6.205 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr16_-_50732707 6.196 ENSMUST00000169791.2
 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr11_+_40733936 6.181 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr11_+_78094660 6.178 ENSMUST00000073705.5
 Fam222b
family with sequence similarity 222, member B
chr2_-_157007039 6.116 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr17_-_53689266 6.031 ENSMUST00000024736.7
 Sgol1
shugoshin-like 1 (S. pombe)
chr12_+_16810940 5.965 ENSMUST00000020908.7
 E2f6
E2F transcription factor 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 600 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 18.9 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
2.2 17.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 15.1 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
4.2 12.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
3.0 12.1 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.4 12.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 11.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
1.0 11.6 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
2.6 10.5 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
2.0 10.2 GO:0007403 glial cell fate determination(GO:0007403)
0.1 10.0 GO:0006457 protein folding(GO:0006457)
1.6 9.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.8 9.0 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
1.5 9.0 GO:0003383 apical constriction(GO:0003383)
0.2 8.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 8.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
2.1 8.5 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.4 8.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.4 8.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.8 8.1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 250 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.9 GO:0000776 kinetochore(GO:0000776)
0.2 18.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 16.1 GO:0043296 apical junction complex(GO:0043296)
0.1 14.6 GO:0000790 nuclear chromatin(GO:0000790)
1.1 14.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 13.4 GO:0090544 BAF-type complex(GO:0090544)
2.9 11.7 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.3 10.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 10.6 GO:0005814 centriole(GO:0005814)
0.2 10.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.5 9.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 9.8 GO:0030027 lamellipodium(GO:0030027)
3.2 9.6 GO:0005673 transcription factor TFIIE complex(GO:0005673)
3.1 9.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 9.4 GO:0001669 acrosomal vesicle(GO:0001669)
1.3 9.3 GO:0005726 perichromatin fibrils(GO:0005726)
1.1 9.2 GO:0033269 internode region of axon(GO:0033269)
0.1 9.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 9.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
1.3 8.8 GO:0001940 male pronucleus(GO:0001940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.6 GO:0001012 RNA polymerase II regulatory region DNA binding(GO:0001012)
0.4 20.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.1 18.3 GO:0030957 Tat protein binding(GO:0030957)
0.2 13.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.9 12.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 12.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 10.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 10.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 10.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 10.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 10.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 9.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 9.8 GO:0042393 histone binding(GO:0042393)
0.2 9.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 9.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 8.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 8.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 8.1 GO:0002039 p53 binding(GO:0002039)
0.1 8.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 7.6 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 33.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 18.8 PID_PLK1_PATHWAY PLK1 signaling events
0.4 18.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 17.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 10.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.7 10.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.4 10.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 7.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.5 7.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.7 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 6.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.3 6.3 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.4 5.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 5.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 5.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.4 4.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 4.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.6 4.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 4.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 43.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 34.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 19.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.7 14.1 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 12.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.6 11.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 11.6 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.7 11.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 11.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 9.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 8.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.3 8.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.3 8.3 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 8.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 8.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 7.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.2 7.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 7.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 6.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 6.8 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus