Motif ID: Olig2_Olig3

Z-value: 0.533

Transcription factors associated with Olig2_Olig3:

Gene SymbolEntrez IDGene Name
Olig2 ENSMUSG00000039830.8 Olig2
Olig3 ENSMUSG00000045591.5 Olig3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Olig2mm10_v2_chr16_+_91225550_91225579-0.191.7e-01Click!
Olig3mm10_v2_chr10_+_19356558_193565650.143.1e-01Click!


Activity profile for motif Olig2_Olig3.

activity profile for motif Olig2_Olig3


Sorted Z-values histogram for motif Olig2_Olig3

Sorted Z-values for motif Olig2_Olig3



Network of associatons between targets according to the STRING database.



First level regulatory network of Olig2_Olig3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 6.126 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_-_186117251 4.750 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr16_-_44558864 3.880 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr16_-_44558879 3.778 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr2_-_105399286 3.547 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr19_-_53589067 3.406 ENSMUST00000095978.3
 Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr14_+_65806066 2.684 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr3_-_154330543 2.660 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr17_-_62606679 2.614 ENSMUST00000163332.1
 Efna5
ephrin A5
chr3_+_125404072 2.481 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404292 2.478 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr11_+_32276400 2.358 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr9_-_119825456 2.357 ENSMUST00000070617.7
 Scn11a
sodium channel, voltage-gated, type XI, alpha
chr5_+_92925400 2.214 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chrX_+_93286499 2.104 ENSMUST00000046565.7
ENSMUST00000113947.2
 Arx

aristaless related homeobox

chr1_+_110099295 2.060 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr15_-_91191733 1.989 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr11_-_69920892 1.981 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr19_+_20601958 1.955 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr3_-_63851251 1.869 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.8 4.8 GO:0098734 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734)
0.0 3.0 GO:0016042 lipid catabolic process(GO:0016042)
0.1 2.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 2.7 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.2 2.6 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.5 2.4 GO:0015671 oxygen transport(GO:0015671)
0.1 2.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 2.1 GO:0021759 globus pallidus development(GO:0021759)
0.4 2.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 2.0 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.5 2.0 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 2.0 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 2.0 GO:0007612 learning(GO:0007612)
0.4 1.8 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 1.8 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.2 1.8 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 1.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.5 1.6 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.9 GO:0030057 desmosome(GO:0030057)
0.4 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.8 2.4 GO:0044299 C-fiber(GO:0044299)
0.3 2.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.9 GO:0043296 apical junction complex(GO:0043296)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.3 1.6 GO:0030870 Mre11 complex(GO:0030870)
0.2 1.6 GO:0005775 vacuolar lumen(GO:0005775)
0.2 1.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.5 1.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.4 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 4.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 2.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 2.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 2.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 2.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.4 2.0 GO:0043532 angiostatin binding(GO:0043532)
0.4 2.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 2.0 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.9 GO:0051015 actin filament binding(GO:0051015)
0.4 1.8 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.3 1.7 GO:0008494 translation activator activity(GO:0008494)
0.4 1.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 1.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.6 GO:0005537 mannose binding(GO:0005537)
0.0 1.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.5 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.3 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 2.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.5 2.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 2.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.6 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines