Motif ID: Onecut1_Cux2

Z-value: 1.133

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.473.1e-04Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.274.3e-02Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 19.318 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_68083853 11.690 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr10_-_64090265 11.476 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090241 11.359 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_102010138 9.490 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr12_+_55598917 8.327 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr12_+_72441933 7.769 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_-_158958367 7.618 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr12_+_72441852 5.661 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr19_-_57197377 4.533 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr9_-_50739365 4.516 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr1_+_165302625 4.516 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chrX_-_43274786 4.462 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr19_-_57197435 4.354 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chrX_+_134404780 4.342 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr6_+_4755327 4.264 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr19_-_57197496 4.193 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chrX_+_134404543 4.041 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr18_-_72351029 3.916 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr18_-_72351009 3.906 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 22.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
3.2 19.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 15.5 GO:0030032 lamellipodium assembly(GO:0030032)
3.9 11.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 9.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
1.3 7.8 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 7.0 GO:0060349 bone morphogenesis(GO:0060349)
0.3 4.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 4.8 GO:0050808 synapse organization(GO:0050808)
0.4 4.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3 4.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 4.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 4.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 3.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
1.1 3.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 2.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9 2.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 2.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 2.2 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.0 2.1 GO:0006446 regulation of translational initiation(GO:0006446)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 15.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
3.9 11.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.7 7.8 GO:0032584 growth cone membrane(GO:0032584)
0.0 4.9 GO:0055037 recycling endosome(GO:0055037)
0.0 4.5 GO:0043679 axon terminus(GO:0043679)
0.1 2.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.6 GO:0030027 lamellipodium(GO:0030027)
0.0 2.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 2.0 GO:0044308 axonal spine(GO:0044308)
0.2 1.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 1.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.1 GO:0042587 glycogen granule(GO:0042587)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.8 GO:0010369 chromocenter(GO:0010369)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 17.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.8 GO:0003779 actin binding(GO:0003779)
0.4 11.7 GO:0043274 phospholipase binding(GO:0043274)
0.1 9.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 9.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 8.3 GO:0003714 transcription corepressor activity(GO:0003714)
1.3 7.8 GO:0005042 netrin receptor activity(GO:0005042)
0.1 7.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.9 6.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 4.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 4.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 3.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 2.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 2.7 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 2.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 4.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 23.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 11.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 7.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 6.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 1.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 1.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling