Motif ID: Onecut1_Cux2
Z-value: 1.133
Transcription factors associated with Onecut1_Cux2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Cux2 | ENSMUSG00000042589.12 | Cux2 |
Cux2 | ENSMUSG00000072641.1 | Cux2 |
Onecut1 | ENSMUSG00000043013.9 | Onecut1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Onecut1 | mm10_v2_chr9_+_74861888_74861921 | 0.47 | 3.1e-04 | Click! |
Cux2 | mm10_v2_chr5_-_122049822_122049882 | -0.27 | 4.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.7 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
3.2 | 19.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.5 | 22.8 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
1.3 | 7.8 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
1.1 | 3.2 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
0.9 | 2.7 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.4 | 4.5 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
0.4 | 1.1 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.3 | 4.5 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.3 | 4.8 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.3 | 9.5 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
0.2 | 1.8 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
0.2 | 2.0 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
0.2 | 1.3 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
0.2 | 1.2 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.2 | 15.5 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.1 | 1.2 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.1 | 0.8 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.1 | 0.5 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.1 | 1.8 | GO:0031507 | heterochromatin assembly(GO:0031507) |
0.1 | 1.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.1 | 2.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.1 | 0.9 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.1 | 4.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.1 | 1.6 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
0.1 | 0.2 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
0.1 | 0.6 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) negative regulation of DNA damage checkpoint(GO:2000002) |
0.1 | 0.7 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.1 | 4.3 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.1 | 0.2 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
0.1 | 0.3 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
0.1 | 7.0 | GO:0060349 | bone morphogenesis(GO:0060349) |
0.1 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.1 | 1.7 | GO:0071625 | vocalization behavior(GO:0071625) |
0.1 | 0.5 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
0.1 | 2.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 3.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
0.0 | 0.9 | GO:0014823 | response to activity(GO:0014823) |
0.0 | 0.3 | GO:0003383 | apical constriction(GO:0003383) |
0.0 | 0.2 | GO:0007128 | meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764) |
0.0 | 2.1 | GO:0006446 | regulation of translational initiation(GO:0006446) |
0.0 | 2.2 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099) |
0.0 | 0.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.0 | 0.3 | GO:0033572 | transferrin transport(GO:0033572) |
0.0 | 0.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 1.5 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
0.0 | 0.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
0.0 | 4.8 | GO:0050808 | synapse organization(GO:0050808) |
0.0 | 1.2 | GO:0021549 | cerebellum development(GO:0021549) |
0.0 | 0.3 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
0.0 | 1.8 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
0.0 | 0.4 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.7 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.7 | 7.8 | GO:0032584 | growth cone membrane(GO:0032584) |
0.3 | 2.0 | GO:0044308 | axonal spine(GO:0044308) |
0.3 | 1.3 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.2 | 1.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.2 | 1.8 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.1 | 15.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.1 | 0.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
0.1 | 2.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.1 | 1.1 | GO:0042587 | glycogen granule(GO:0042587) |
0.1 | 34.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.1 | 0.8 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
0.1 | 0.3 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
0.1 | 2.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.1 | 0.7 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.1 | 0.6 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.1 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.8 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 4.9 | GO:0055037 | recycling endosome(GO:0055037) |
0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
0.0 | 0.3 | GO:0031931 | TORC1 complex(GO:0031931) |
0.0 | 2.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 4.5 | GO:0043679 | axon terminus(GO:0043679) |
0.0 | 0.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 2.2 | GO:0072686 | mitotic spindle(GO:0072686) |
0.0 | 0.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 2.6 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 7.8 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.9 | 6.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
0.4 | 11.7 | GO:0043274 | phospholipase binding(GO:0043274) |
0.4 | 4.8 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.3 | 1.3 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
0.3 | 2.0 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.2 | 1.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.2 | 0.8 | GO:0000995 | transcription factor activity, core RNA polymerase III binding(GO:0000995) |
0.2 | 22.8 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
0.2 | 2.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.2 | 1.8 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.1 | 9.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 4.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.1 | 0.9 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 0.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
0.1 | 0.8 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
0.1 | 2.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.1 | 17.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 7.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 0.9 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
0.1 | 0.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
0.1 | 0.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.0 | 2.2 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.0 | 8.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
0.0 | 3.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.0 | 2.2 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.0 | 0.2 | GO:0017040 | ceramidase activity(GO:0017040) |
0.0 | 11.8 | GO:0003779 | actin binding(GO:0003779) |
0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
0.0 | 0.8 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 2.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
0.0 | 9.0 | GO:0008270 | zinc ion binding(GO:0008270) |
0.0 | 0.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
0.0 | 0.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.0 | 2.7 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
0.0 | 0.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 7.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.1 | 0.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
0.0 | 4.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 1.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 4.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 1.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 3.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 1.8 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 0.5 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.3 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 23.9 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.5 | 7.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.5 | 11.7 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.2 | 1.8 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.2 | 1.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
0.2 | 6.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.1 | 2.5 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.1 | 0.4 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.1 | 0.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.0 | 1.2 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
0.0 | 1.2 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 0.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
0.0 | 0.8 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 0.3 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |