Motif ID: Onecut1_Cux2

Z-value: 1.133

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.473.1e-04Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.274.3e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 19.318 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr14_+_68083853 11.690 ENSMUST00000022639.7
Nefl
neurofilament, light polypeptide
chr10_-_64090265 11.476 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090241 11.359 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_102010138 9.490 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr12_+_55598917 8.327 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr12_+_72441933 7.769 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr1_-_158958367 7.618 ENSMUST00000159861.2
Pappa2
pappalysin 2
chr12_+_72441852 5.661 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr19_-_57197377 4.533 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr9_-_50739365 4.516 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chr1_+_165302625 4.516 ENSMUST00000111450.1
Gpr161
G protein-coupled receptor 161
chrX_-_43274786 4.462 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr19_-_57197435 4.354 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chrX_+_134404780 4.342 ENSMUST00000113224.2
ENSMUST00000113226.1
Drp2

dystrophin related protein 2

chr6_+_4755327 4.264 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr19_-_57197496 4.193 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chrX_+_134404543 4.041 ENSMUST00000113228.1
ENSMUST00000153424.1
Drp2

dystrophin related protein 2

chr18_-_72351029 3.916 ENSMUST00000114943.3
Dcc
deleted in colorectal carcinoma
chr18_-_72351009 3.906 ENSMUST00000073379.5
Dcc
deleted in colorectal carcinoma
chr7_+_35802593 3.639 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr10_-_112928974 3.548 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr3_+_125404072 3.244 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_8509477 3.151 ENSMUST00000029002.7
Stmn2
stathmin-like 2
chr8_+_58911755 3.149 ENSMUST00000062978.6
BC030500
cDNA sequence BC030500
chr19_-_57197556 2.961 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr3_+_125404292 2.870 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr19_-_37178011 2.749 ENSMUST00000133988.1
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr4_+_62965560 2.596 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
Zfp618


zinc finger protein 618


chr13_+_93304940 2.572 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
Homer1





homer homolog 1 (Drosophila)





chr8_-_58911627 2.528 ENSMUST00000077447.4
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr13_+_93304799 2.265 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr1_-_54194048 2.191 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr7_+_75848338 2.083 ENSMUST00000092073.5
ENSMUST00000171155.2
Klhl25

kelch-like 25

chrX_+_56609751 2.012 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr7_-_127448993 1.888 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr9_-_29963112 1.839 ENSMUST00000075069.4
Ntm
neurotrimin
chr9_+_54980880 1.802 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr7_-_127449109 1.799 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr11_+_120232921 1.762 ENSMUST00000122148.1
ENSMUST00000044985.7
Bahcc1

BAH domain and coiled-coil containing 1

chr9_+_59589288 1.729 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr2_-_72986716 1.672 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr1_+_191717834 1.601 ENSMUST00000110855.1
ENSMUST00000133076.1
Lpgat1

lysophosphatidylglycerol acyltransferase 1

chr7_+_45627482 1.459 ENSMUST00000057927.7
Rasip1
Ras interacting protein 1
chr18_+_35965088 1.426 ENSMUST00000175734.1
Psd2
pleckstrin and Sec7 domain containing 2
chr18_+_35965036 1.361 ENSMUST00000176873.1
ENSMUST00000177432.1
Psd2

pleckstrin and Sec7 domain containing 2

chr3_-_33082004 1.316 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr2_-_7081207 1.263 ENSMUST00000114923.2
ENSMUST00000182706.1
Celf2

CUGBP, Elav-like family member 2

chr1_-_89933290 1.212 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr15_+_92161343 1.176 ENSMUST00000068378.5
Cntn1
contactin 1
chr8_-_8660773 1.175 ENSMUST00000001319.7
Efnb2
ephrin B2
chr19_+_26750939 1.034 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_-_55092277 1.018 ENSMUST00000036328.8
Zfhx2
zinc finger homeobox 2
chr5_+_63649335 1.003 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr2_-_7081256 0.911 ENSMUST00000183209.1
Celf2
CUGBP, Elav-like family member 2
chr2_+_163602331 0.904 ENSMUST00000152135.1
Ttpal
tocopherol (alpha) transfer protein-like
chr2_+_163602294 0.864 ENSMUST00000171696.1
ENSMUST00000109408.3
Ttpal

tocopherol (alpha) transfer protein-like

chr6_+_29853746 0.858 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr2_-_32451396 0.856 ENSMUST00000028160.8
ENSMUST00000113310.2
Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

chr8_-_79399513 0.827 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
Smad1


SMAD family member 1


chr8_+_20136455 0.823 ENSMUST00000179299.1
ENSMUST00000096485.4
Gm21811

predicted gene, 21811

chr1_-_54438940 0.804 ENSMUST00000041638.6
Gtf3c3
general transcription factor IIIC, polypeptide 3
chr15_-_103215285 0.790 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chr17_+_55986494 0.753 ENSMUST00000011733.8
Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr2_-_168767136 0.719 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr4_+_109343029 0.689 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr4_-_46991842 0.672 ENSMUST00000107749.2
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr4_-_97584612 0.666 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 0.662 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_+_32431225 0.618 ENSMUST00000115140.1
Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
chr11_+_4902212 0.566 ENSMUST00000142543.1
Thoc5
THO complex 5
chr3_-_129755305 0.545 ENSMUST00000029653.2
Egf
epidermal growth factor
chr16_+_32430895 0.525 ENSMUST00000115137.1
ENSMUST00000079791.4
Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

chr19_+_31082841 0.507 ENSMUST00000066039.6
Cstf2t
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr13_-_54688246 0.479 ENSMUST00000122935.1
ENSMUST00000128257.1
Rnf44

ring finger protein 44

chr4_+_5724304 0.456 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr12_-_84698769 0.424 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chrX_+_41401128 0.410 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr7_+_25152456 0.350 ENSMUST00000098678.1
D930028M14Rik
RIKEN cDNA D930028M14 gene
chr5_+_144100387 0.343 ENSMUST00000041804.7
Lmtk2
lemur tyrosine kinase 2
chr17_-_24479034 0.341 ENSMUST00000179163.1
ENSMUST00000070888.6
Mlst8

MTOR associated protein, LST8 homolog (S. cerevisiae)

chr11_+_97315716 0.323 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chr2_-_92392634 0.293 ENSMUST00000111279.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr8_+_127064107 0.284 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr11_-_120624973 0.251 ENSMUST00000106183.2
ENSMUST00000080202.5
Sirt7

sirtuin 7

chr15_-_42676967 0.249 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr8_+_113643206 0.216 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr12_-_46818749 0.204 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr18_+_12972225 0.195 ENSMUST00000025290.5
Impact
imprinted and ancient
chr19_-_32061438 0.158 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr7_-_116084635 0.139 ENSMUST00000111755.3
Gm4353
predicted gene 4353
chrX_-_51205990 0.131 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr1_-_51941261 0.079 ENSMUST00000097103.3
Gm8420
predicted gene 8420
chr17_-_71459300 0.063 ENSMUST00000183937.1
Gm4707
predicted gene 4707
chr2_-_25224653 0.040 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
3.2 19.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.5 22.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
1.3 7.8 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
1.1 3.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.9 2.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.4 4.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.4 1.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 4.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.3 4.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.3 9.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 1.8 GO:0035095 behavioral response to nicotine(GO:0035095)
0.2 2.0 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.2 1.3 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2 15.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.5 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 1.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 4.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.6 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 0.6 GO:0045650 negative regulation of macrophage differentiation(GO:0045650) negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.7 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.1 4.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 0.2 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.3 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1 7.0 GO:0060349 bone morphogenesis(GO:0060349)
0.1 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.7 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 2.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 3.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.9 GO:0014823 response to activity(GO:0014823)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.0 2.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 2.2 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.0 0.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0033572 transferrin transport(GO:0033572)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 4.8 GO:0050808 synapse organization(GO:0050808)
0.0 1.2 GO:0021549 cerebellum development(GO:0021549)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.4 GO:0001919 regulation of receptor recycling(GO:0001919)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.7 7.8 GO:0032584 growth cone membrane(GO:0032584)
0.3 2.0 GO:0044308 axonal spine(GO:0044308)
0.3 1.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 15.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0042587 glycogen granule(GO:0042587)
0.1 34.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 0.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.3 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 2.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0010369 chromocenter(GO:0010369)
0.0 4.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.5 GO:0043679 axon terminus(GO:0043679)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.6 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.8 GO:0005042 netrin receptor activity(GO:0005042)
0.9 6.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 11.7 GO:0043274 phospholipase binding(GO:0043274)
0.4 4.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 1.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.3 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 1.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.8 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.2 22.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 2.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 1.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 9.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.8 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 17.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 7.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.3 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 2.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 8.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 11.8 GO:0003779 actin binding(GO:0003779)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 2.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 9.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.7 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 4.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 4.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 23.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 7.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 11.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 1.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.2 6.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC