Motif ID: Onecut2_Onecut3

Z-value: 0.678

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut3mm10_v2_chr10_+_80494835_804948730.341.2e-02Click!
Onecut2mm10_v2_chr18_+_64340225_64340364-0.162.6e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 9.382 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_49636847 6.029 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_109545390 4.564 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_+_109544498 3.762 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr4_+_109343029 2.686 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr9_-_86695897 2.375 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_102010138 2.312 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr10_+_69533761 2.305 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chrY_+_897782 2.279 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr4_+_43384332 1.843 ENSMUST00000136360.1
 Rusc2
RUN and SH3 domain containing 2
chr13_-_56895737 1.775 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr10_-_45470201 1.719 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr15_-_42676967 1.663 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr1_-_64121456 1.594 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr3_+_136670076 1.503 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_-_41273977 1.482 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr4_+_145510759 1.194 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr11_+_46235460 1.182 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr6_+_5390387 1.161 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr12_+_74297474 1.146 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 7.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 6.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.3 2.7 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.5 2.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.5 2.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 2.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.3 GO:0007411 axon guidance(GO:0007411)
0.7 2.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.2 2.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.8 GO:0006828 manganese ion transport(GO:0006828)
0.6 1.7 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.4 1.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 1.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 1.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 1.2 GO:0060349 bone morphogenesis(GO:0060349)
0.4 1.1 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 2.1 GO:0005955 calcineurin complex(GO:0005955)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 1.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.2 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.0 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.1 0.8 GO:0089701 U2AF(GO:0089701)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.4 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 2.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3 2.3 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.0 2.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.2 1.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.8 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 1.8 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.3 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression