ISMARA results: Osr2

Motif ID: Osr2_Osr1

Z-value: 0.804

Transcription factors associated with Osr2_Osr1:

Gene Symbol	Entrez ID	Gene Name
Osr1	ENSMUSG00000048387.7	Osr1
Osr2	ENSMUSG00000022330.4	Osr2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Osr1	mm10_v2_chr12_+_9574437_9574448	0.25	7.0e-02	Click!

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Top targets:

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Showing 1 to 20 of 172 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_80128834	6.308	ENSMUST00000102654.4 ENSMUST00000102655.3	Pde1a	phosphodiesterase 1A, calmodulin-dependent
chr4_-_134254076	4.506	ENSMUST00000060050.5	Grrp1	glycine/arginine rich protein 1
chr4_+_13743424	4.498	ENSMUST00000006761.3	Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_-_109823585	3.738	ENSMUST00000161582.1	Nav3	neuron navigator 3
chr7_-_57509995	3.600	ENSMUST00000068456.6	Gabra5	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr4_+_102087543	2.986	ENSMUST00000106911.1	Pde4b	phosphodiesterase 4B, cAMP specific
chr2_+_136892168	2.886	ENSMUST00000099311.2	Slx4ip	SLX4 interacting protein
chr6_-_59024470	2.619	ENSMUST00000089860.5	Fam13a	family with sequence similarity 13, member A
chr4_+_135963742	2.516	ENSMUST00000149636.1 ENSMUST00000143304.1	Gale	galactose-4-epimerase, UDP
chr6_-_144209448	2.416	ENSMUST00000077160.5	Sox5	SRY-box containing gene 5
chr5_+_107497762	2.380	ENSMUST00000152474.1 ENSMUST00000060553.7	A830010M20Rik	RIKEN cDNA A830010M20 gene
chr14_-_20480106	2.377	ENSMUST00000065504.9 ENSMUST00000100844.4	Anxa7	annexin A7
chr7_-_123500449	2.332	ENSMUST00000042470.7 ENSMUST00000128217.1	Zkscan2	zinc finger with KRAB and SCAN domains 2
chr3_-_89322883	2.308	ENSMUST00000029673.5	Efna3	ephrin A3
chr6_-_144209471	2.284	ENSMUST00000038815.7	Sox5	SRY-box containing gene 5
chr6_-_59024340	2.268	ENSMUST00000173193.1	Fam13a	family with sequence similarity 13, member A
chr3_-_127225847	2.256	ENSMUST00000182726.1 ENSMUST00000182779.1	Ank2	ankyrin 2, brain
chr5_+_107497718	2.198	ENSMUST00000112671.2	A830010M20Rik	RIKEN cDNA A830010M20 gene
chr15_-_43869993	2.104	ENSMUST00000067469.4	Tmem74	transmembrane protein 74
chr1_-_43163891	2.100	ENSMUST00000008280.7	Fhl2	four and a half LIM domains 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 82 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	6.7	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.4	6.3	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	4.9	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.1	4.4	GO:0061623	glycolytic process from galactose(GO:0061623)
0.5	4.2	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1	3.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	3.1	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.2	3.0	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	2.7	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)
0.8	2.5	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.3	2.4	GO:1904217	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1	2.4	GO:0006884	cell volume homeostasis(GO:0006884)
0.5	2.3	GO:1905247	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2	2.1	GO:0060347	heart trabecula formation(GO:0060347)
0.1	2.0	GO:0010842	retina layer formation(GO:0010842)
0.0	2.0	GO:0048477	oogenesis(GO:0048477)
0.1	1.8	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.6	1.7	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)
0.3	1.7	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.5	1.5	GO:0071963	establishment or maintenance of cell polarity regulating cell shape(GO:0071963)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 31 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.3	GO:0031430	M band(GO:0031430)
0.0	5.9	GO:0030027	lamellipodium(GO:0030027)
0.0	5.1	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	4.7	GO:0016363	nuclear matrix(GO:0016363)
0.2	3.6	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	3.0	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	2.5	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.8	2.4	GO:0042584	chromaffin granule membrane(GO:0042584)
0.4	1.7	GO:0097447	dendritic tree(GO:0097447)
0.1	1.7	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1	1.5	GO:0071437	invadopodium(GO:0071437)
0.1	1.3	GO:0061617	MICOS complex(GO:0061617)
0.3	1.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.3	1.2	GO:1990032	parallel fiber(GO:1990032)
0.0	1.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	1.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.3	1.0	GO:0098592	cytoplasmic side of apical plasma membrane(GO:0098592)
0.2	1.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	0.9	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.1	0.9	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 62 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.8	GO:0003714	transcription corepressor activity(GO:0003714)
0.9	6.3	GO:0048101	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3	4.4	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1	4.2	GO:0030507	spectrin binding(GO:0030507)
0.2	3.6	GO:0050811	GABA receptor binding(GO:0050811)
0.1	3.0	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2	2.5	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	2.5	GO:0070064	proline-rich region binding(GO:0070064)
0.2	2.4	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1	2.4	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	2.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	2.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	2.0	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)
0.0	2.0	GO:0017137	Rab GTPase binding(GO:0017137)
0.6	1.7	GO:0034437	very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1	1.7	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	1.5	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	1.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	1.2	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4	1.2	GO:0004936	alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)

Gene overrepresentation in C2:CP category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.4	PID_CDC42_REG_PATHWAY	Regulation of CDC42 activity
0.0	3.9	NABA_ECM_AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	3.1	PID_NFAT_TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	2.6	PID_S1P_S1P2_PATHWAY	S1P2 pathway
0.1	2.3	PID_EPHA_FWDPATHWAY	EPHA forward signaling
0.1	2.1	PID_HDAC_CLASSIII_PATHWAY	Signaling events mediated by HDAC Class III
0.1	2.1	PID_MAPK_TRK_PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	1.7	PID_UPA_UPAR_PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	1.5	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.0	1.2	PID_RAS_PATHWAY	Regulation of Ras family activation
0.0	1.0	PID_NCADHERIN_PATHWAY	N-cadherin signaling events
0.0	1.0	PID_INSULIN_PATHWAY	Insulin Pathway
0.0	0.9	PID_AURORA_B_PATHWAY	Aurora B signaling
0.0	0.7	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.0	0.4	PID_HIF1A_PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	ST_TYPE_I_INTERFERON_PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 29 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.2	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.2	6.3	REACTOME_CGMP_EFFECTS	Genes involved in cGMP effects
0.0	4.8	REACTOME_METABOLISM_OF_CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.2	3.6	REACTOME_GABA_A_RECEPTOR_ACTIVATION	Genes involved in GABA A receptor activation
0.1	3.0	REACTOME_DARPP_32_EVENTS	Genes involved in DARPP-32 events
0.0	2.1	REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.1	1.7	REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN	Genes involved in Signalling to p38 via RIT and RIN
0.1	1.5	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.5	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.3	REACTOME_COLLAGEN_FORMATION	Genes involved in Collagen formation
0.1	1.2	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	1.2	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	1.1	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.1	REACTOME_PLC_BETA_MEDIATED_EVENTS	Genes involved in PLC beta mediated events
0.0	1.0	REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.0	REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	0.9	REACTOME_CHOLESTEROL_BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.9	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	0.8	REACTOME_ETHANOL_OXIDATION	Genes involved in Ethanol oxidation
0.0	0.8	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis