Motif ID: Otx1

Z-value: 0.394


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.095.1e-01Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_108479849 2.010 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr5_-_98566762 1.494 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr10_+_3973086 1.147 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr7_-_38271310 1.042 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr16_-_59632520 0.951 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr5_-_5749317 0.882 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr10_-_88605017 0.880 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr17_+_35861318 0.858 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr11_+_94936224 0.847 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr1_-_165708088 0.847 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr3_+_54481429 0.838 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr14_-_87141206 0.821 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr11_+_78346666 0.815 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr2_-_60963192 0.798 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr13_-_21750505 0.792 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr5_-_37336870 0.733 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr8_-_47675556 0.728 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr1_+_131910458 0.714 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr12_-_46818749 0.694 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chrX_-_48513518 0.687 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr13_-_60897439 0.658 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr7_-_4063195 0.615 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr14_-_122913751 0.589 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr14_-_87141114 0.587 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr15_-_74734313 0.587 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr4_-_41517326 0.552 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr13_+_21180179 0.548 ENSMUST00000021761.5
 Trim27
tripartite motif-containing 27
chr11_-_116694802 0.543 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr17_+_35861343 0.511 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr13_+_21735055 0.509 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_+_41016250 0.501 ENSMUST00000021790.5
 Tmem14c
transmembrane protein 14C
chr11_+_115564434 0.500 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr10_+_61648552 0.494 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chrX_-_167209149 0.492 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr2_-_151980135 0.477 ENSMUST00000062047.5
 Fam110a
family with sequence similarity 110, member A
chr5_-_37336837 0.468 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr9_-_109082372 0.457 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr3_-_105960099 0.452 ENSMUST00000118209.1
 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr2_+_154656959 0.409 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chr10_+_127642975 0.392 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr5_+_15516489 0.385 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr15_-_79285502 0.374 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr7_-_118129567 0.368 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr11_-_116274102 0.344 ENSMUST00000106425.3
 Srp68
signal recognition particle 68
chr19_-_7039987 0.341 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr10_-_93889758 0.337 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr18_+_86711520 0.336 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr6_-_136828186 0.330 ENSMUST00000116514.1
 Wbp11
WW domain binding protein 11
chr2_-_144011202 0.324 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr19_-_6057736 0.321 ENSMUST00000007482.6
 Mrpl49
mitochondrial ribosomal protein L49
chr10_+_80054029 0.309 ENSMUST00000097227.3
 Gpx4
glutathione peroxidase 4
chr5_-_100373484 0.309 ENSMUST00000182433.1
 Sec31a
Sec31 homolog A (S. cerevisiae)
chr4_-_42661893 0.299 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chrM_+_11734 0.286 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_+_118321834 0.280 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr7_-_79848191 0.270 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr5_-_104456467 0.254 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr11_+_100545607 0.254 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25

chr4_-_123750236 0.247 ENSMUST00000102636.3
 Akirin1
akirin 1
chr9_-_66975387 0.246 ENSMUST00000034929.6
 Lactb
lactamase, beta
chr2_-_11603192 0.243 ENSMUST00000040314.5
 Rbm17
RNA binding motif protein 17
chr19_+_4097392 0.235 ENSMUST00000174514.1
ENSMUST00000174149.1
 Cdk2ap2

CDK2-associated protein 2

chr17_+_8165501 0.232 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr11_+_3963970 0.232 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr11_-_116274197 0.223 ENSMUST00000021133.9
 Srp68
signal recognition particle 68
chr19_+_5689131 0.216 ENSMUST00000004156.8
 Map3k11
mitogen-activated protein kinase kinase kinase 11
chr2_-_26933781 0.199 ENSMUST00000154651.1
ENSMUST00000015011.3
 Surf4

surfeit gene 4

chr7_-_100662315 0.185 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr13_+_90089705 0.173 ENSMUST00000012566.8
 Tmem167
transmembrane protein 167
chr10_+_29313164 0.151 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr7_-_132154717 0.139 ENSMUST00000033149.4
 Cpxm2
carboxypeptidase X 2 (M14 family)
chr7_-_100662414 0.137 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr2_+_28468056 0.130 ENSMUST00000038600.3
 Mrps2
mitochondrial ribosomal protein S2
chr13_+_21495218 0.119 ENSMUST00000104942.1
 AK157302
cDNA sequence AK157302
chr18_+_80206887 0.118 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr17_-_47611449 0.114 ENSMUST00000024783.8
 Bysl
bystin-like
chr1_-_118311132 0.108 ENSMUST00000027623.7
 Tsn
translin
chr13_+_93771656 0.107 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr7_-_83550258 0.103 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chrX_-_95956890 0.096 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chr13_-_55321928 0.088 ENSMUST00000035242.7
 Rab24
RAB24, member RAS oncogene family
chr13_-_92030897 0.088 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr9_+_68653761 0.083 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr7_-_104950441 0.069 ENSMUST00000179862.1
 Gm5900
predicted pseudogene 5900
chrM_+_10167 0.061 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr14_+_105258673 0.060 ENSMUST00000136040.2
 Ndfip2
Nedd4 family interacting protein 2
chr2_-_156180135 0.058 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr14_+_29968308 0.037 ENSMUST00000112268.1
 Selk
selenoprotein K
chr19_+_41933464 0.030 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr3_+_66985647 0.027 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr10_-_7473361 0.024 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr2_-_86347764 0.017 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.2 0.7 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.2 1.0 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 1.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 0.5 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 0.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.8 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.1 0.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.5 GO:0097503 sialylation(GO:0097503)
0.1 0.8 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.4 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.1 1.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.4 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.7 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.4 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 1.2 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.5 GO:0048246 macrophage chemotaxis(GO:0048246)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0043256 laminin complex(GO:0043256)
0.3 0.8 GO:0005584 collagen type I trimer(GO:0005584)
0.2 1.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.9 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.4 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 0.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.3 0.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 1.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.6 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.7 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC