Motif ID: Pax2

Z-value: 0.984


Transcription factors associated with Pax2:

Gene SymbolEntrez IDGene Name
Pax2 ENSMUSG00000004231.9 Pax2



Activity profile for motif Pax2.

activity profile for motif Pax2


Sorted Z-values histogram for motif Pax2

Sorted Z-values for motif Pax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039035 4.539 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039097 4.264 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_-_82291370 3.700 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr5_-_106458440 3.488 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr12_-_102878406 3.261 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr12_-_101028983 3.067 ENSMUST00000068411.3
ENSMUST00000085096.3
 Ccdc88c

coiled-coil domain containing 88C

chr17_+_26715644 2.996 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr3_+_135212557 2.877 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr19_-_7105729 2.777 ENSMUST00000113383.2
 Flrt1
fibronectin leucine rich transmembrane protein 1
chr7_-_37773555 2.755 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr5_+_64803513 2.524 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr9_-_91365778 2.425 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr9_-_91365756 2.398 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr2_+_119897212 2.310 ENSMUST00000046717.6
ENSMUST00000110774.1
ENSMUST00000110773.2
ENSMUST00000079934.5
ENSMUST00000156510.1
 Mga




MAX gene associated




chr9_-_42124276 2.272 ENSMUST00000060989.8
 Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr10_+_41519493 2.160 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr6_+_113531675 2.149 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr2_+_48949495 2.131 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr16_+_94370786 2.028 ENSMUST00000147046.1
ENSMUST00000149885.1
ENSMUST00000127667.1
ENSMUST00000119131.1
ENSMUST00000145883.1
 Ttc3




tetratricopeptide repeat domain 3




chr15_+_39198244 1.997 ENSMUST00000082054.5
ENSMUST00000042917.9
 Rims2

regulating synaptic membrane exocytosis 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.8 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 5.0 GO:0007628 adult walking behavior(GO:0007628)
1.6 4.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.9 4.4 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.5 4.3 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1 4.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 3.7 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 3.5 GO:0001709 cell fate determination(GO:0001709)
0.1 3.4 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.2 3.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 3.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 3.1 GO:0031648 protein destabilization(GO:0031648)
0.0 3.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.6 3.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.6 3.0 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.7 2.9 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 2.8 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 2.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.5 2.5 GO:0042117 monocyte activation(GO:0042117)
0.3 2.2 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 GO:0090544 BAF-type complex(GO:0090544)
1.2 3.7 GO:0005899 insulin receptor complex(GO:0005899)
0.3 2.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 2.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.2 2.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3 2.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 2.1 GO:0010369 chromocenter(GO:0010369)
0.0 2.0 GO:0000502 proteasome complex(GO:0000502)
0.1 1.9 GO:0035861 site of double-strand break(GO:0035861)
0.2 1.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.7 GO:1990635 proximal dendrite(GO:1990635)
0.4 1.6 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 1.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 1.5 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.9 8.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4 3.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.0 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.6 2.9 GO:0043515 kinetochore binding(GO:0043515)
0.4 2.9 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.2 2.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 2.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 2.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 2.0 GO:0051117 ATPase binding(GO:0051117)
0.3 1.9 GO:0061649 ubiquitinated histone binding(GO:0061649)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 2.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 2.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.1 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 3.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 2.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4 2.2 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.2 2.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.0 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 1.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.5 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE