Motif ID: Pax3
Z-value: 0.468
Transcription factors associated with Pax3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pax3 | ENSMUSG00000004872.9 | Pax3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pax3 | mm10_v2_chr1_-_78196832_78196845 | 0.15 | 2.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.0 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.3 | 1.1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.3 | 1.0 | GO:0018307 | tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307) |
| 0.2 | 1.0 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.2 | 1.4 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.2 | 1.7 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.4 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 2.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 1.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.0 | 1.7 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.2 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 1.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 1.3 | GO:0003170 | heart valve development(GO:0003170) |
| 0.0 | 2.2 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway(GO:2001237) |
| 0.0 | 0.4 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.0 | 0.7 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.0 | 2.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 1.1 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.0 | 2.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.1 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.4 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0004686 | elongation factor-2 kinase activity(GO:0004686) |
| 0.2 | 1.0 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.1 | 2.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 2.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.4 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 2.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 2.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.1 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.4 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 2.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.7 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 2.1 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.0 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.2 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
