Motif ID: Pax3

Z-value: 0.468


Transcription factors associated with Pax3:

Gene SymbolEntrez IDGene Name
Pax3 ENSMUSG00000004872.9 Pax3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78196832_781968450.152.7e-01Click!


Activity profile for motif Pax3.

activity profile for motif Pax3


Sorted Z-values histogram for motif Pax3

Sorted Z-values for motif Pax3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax3

PNG image of the network

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Top targets:


Showing 1 to 20 of 39 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_114474312 2.491 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr9_-_40346290 2.420 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr14_+_51893610 2.292 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr2_-_136387929 2.245 ENSMUST00000035264.2
ENSMUST00000077200.3
 Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chrX_+_159840463 2.051 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr10_+_82138253 1.746 ENSMUST00000105314.2
 AU041133
expressed sequence AU041133
chr4_+_127077374 1.713 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr7_+_120843551 1.683 ENSMUST00000106489.1
ENSMUST00000143279.1
 Eef2k

eukaryotic elongation factor-2 kinase

chr10_-_70592782 1.629 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr18_+_35562158 1.524 ENSMUST00000166793.1
 Matr3
matrin 3
chr11_-_88851462 1.394 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr12_+_109540979 1.308 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr8_+_71887264 1.273 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chrX_-_103623648 1.209 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr1_+_176814660 1.208 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr12_+_52699297 1.127 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr16_-_32877723 1.122 ENSMUST00000119810.1
 1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr2_+_168230597 1.004 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr17_+_87107621 0.961 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr3_+_36159522 0.898 ENSMUST00000165956.2
 D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 2.2 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
0.0 2.1 GO:0008360 regulation of cell shape(GO:0008360)
0.4 2.0 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 1.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 1.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 1.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.3 GO:0003170 heart valve development(GO:0003170)
0.3 1.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 1.0 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.2 1.0 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.7 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.4 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)

Gene overrepresentation in molecular_function category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 2.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.6 1.7 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.2 1.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.0 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.7 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane