Motif ID: Pax4

Z-value: 0.413


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_32696005 1.626 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr15_-_88978958 1.506 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chrX_+_73192222 1.392 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chrX_+_9199865 1.280 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr12_-_90738438 1.224 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr8_-_84773381 1.195 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_-_73097017 1.161 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr4_-_88033328 1.040 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_+_78499087 1.034 ENSMUST00000017488.4
 Vtn
vitronectin
chr2_+_73271925 0.955 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr4_+_136357423 0.943 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr13_-_101768154 0.898 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr15_-_79164477 0.852 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr12_+_71048338 0.722 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr2_-_125506385 0.706 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr2_+_158666690 0.668 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr13_+_109632760 0.665 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr2_+_158667119 0.608 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_+_62574523 0.606 ENSMUST00000018651.7
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr9_-_58159201 0.547 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.6 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 1.5 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.3 1.3 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.2 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.0 GO:0097421 liver regeneration(GO:0097421)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 0.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 0.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.6 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.1 0.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.4 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.4 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.4 GO:0016486 peptide hormone processing(GO:0016486)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0055037 recycling endosome(GO:0055037)
0.1 2.6 GO:0000800 lateral element(GO:0000800)
0.2 1.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 0.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 1.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 0.4 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis