Motif ID: Pax4
Z-value: 0.413
Transcription factors associated with Pax4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pax4 | ENSMUSG00000029706.9 | Pax4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 0.3 | 1.3 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.2 | 1.2 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) |
| 0.2 | 0.7 | GO:1903011 | negative regulation of bone development(GO:1903011) |
| 0.2 | 0.9 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.2 | 1.5 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397) |
| 0.1 | 0.7 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 0.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 1.0 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.1 | 0.9 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.1 | 0.5 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 1.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.1 | 1.0 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 0.7 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.1 | 0.4 | GO:0098707 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.0 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.2 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.0 | 0.2 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.0 | 0.1 | GO:0002326 | B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234) |
| 0.0 | 0.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 1.0 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.3 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.0 | GO:0019405 | hexitol metabolic process(GO:0006059) alditol catabolic process(GO:0019405) fructose biosynthetic process(GO:0046370) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.6 | GO:0090280 | positive regulation of calcium ion import(GO:0090280) |
| 0.0 | 0.1 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
| 0.0 | 0.2 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.0 | 0.0 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 2.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 0.9 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 0.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.4 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.1 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.0 | 0.9 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.2 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.1 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.0 | 0.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 2.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.1 | 0.5 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 0.3 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
| 0.1 | 0.4 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.1 | 1.0 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.1 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.0 | 0.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.2 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 1.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.8 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.1 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 0.0 | 0.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.5 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 1.4 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 1.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 2.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.9 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 0.5 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 0.4 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 0.5 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.7 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
