Motif ID: Pax5

Z-value: 1.516


Transcription factors associated with Pax5:

Gene SymbolEntrez IDGene Name
Pax5 ENSMUSG00000014030.9 Pax5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax5mm10_v2_chr4_-_44704006_447040060.221.0e-01Click!


Activity profile for motif Pax5.

activity profile for motif Pax5


Sorted Z-values histogram for motif Pax5

Sorted Z-values for motif Pax5



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127725392 10.078 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr2_+_91945703 7.842 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr3_+_89520152 7.667 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr11_-_102897123 5.846 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr15_-_78773452 5.748 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_-_37384915 5.485 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr11_-_77894096 5.373 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_-_190170178 5.370 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr1_-_190170671 5.207 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr9_-_82975475 5.085 ENSMUST00000034787.5
 Phip
pleckstrin homology domain interacting protein
chr14_+_45219993 4.521 ENSMUST00000146150.1
 Gpr137c
G protein-coupled receptor 137C
chr3_-_116968827 4.186 ENSMUST00000119557.1
 Palmd
palmdelphin
chr7_-_116443439 4.178 ENSMUST00000170430.1
 Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr16_-_37384940 4.105 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr11_-_102897146 3.994 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_-_18514802 3.963 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr3_-_116968969 3.729 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr10_-_128919259 3.676 ENSMUST00000149961.1
ENSMUST00000026406.7
 Rdh5

retinol dehydrogenase 5

chr12_-_34528844 3.671 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr16_+_43235856 3.613 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 344 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 10.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.5 10.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.2 10.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
2.5 10.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 9.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 8.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 7.1 GO:0008360 regulation of cell shape(GO:0008360)
0.9 7.0 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 6.9 GO:0030033 microvillus assembly(GO:0030033)
0.6 6.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 5.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 5.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 5.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
1.8 5.4 GO:0006553 lysine metabolic process(GO:0006553)
1.1 5.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.5 5.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.5 5.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.4 4.8 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 4.7 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.3 4.5 GO:0015701 bicarbonate transport(GO:0015701)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.6 GO:0005871 kinesin complex(GO:0005871)
2.5 9.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 8.7 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 7.9 GO:0016605 PML body(GO:0016605)
0.8 6.8 GO:0030478 actin cap(GO:0030478)
0.2 6.5 GO:0002102 podosome(GO:0002102)
0.1 6.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.8 GO:0005938 cell cortex(GO:0005938)
1.4 5.6 GO:0097441 basilar dendrite(GO:0097441)
0.2 5.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 4.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 4.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.1 GO:0043235 receptor complex(GO:0043235)
0.2 3.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 3.7 GO:0060077 inhibitory synapse(GO:0060077)
0.9 3.6 GO:0043259 laminin-10 complex(GO:0043259)
0.2 3.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.5 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 14.1 GO:0005178 integrin binding(GO:0005178)
0.9 10.6 GO:0050693 LBD domain binding(GO:0050693)
0.5 9.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 8.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 8.1 GO:0008017 microtubule binding(GO:0008017)
0.1 7.9 GO:0003777 microtubule motor activity(GO:0003777)
1.8 7.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.6 7.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 6.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.6 6.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 6.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 6.0 GO:0017091 AU-rich element binding(GO:0017091)
0.5 5.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 5.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.9 5.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.6 5.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.3 5.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.4 4.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.5 4.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 6.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.4 4.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 4.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.8 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.5 3.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 3.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 3.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 3.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.2 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 8.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 7.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 5.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.3 5.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 5.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 3.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 3.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 3.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.9 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 2.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 2.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 2.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 2.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production