Motif ID: Pax6

Z-value: 0.803


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.892.3e-19Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 8.571 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_57118981 7.646 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr19_-_57118897 6.653 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr3_+_65109343 5.331 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr13_-_110280103 5.308 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr1_-_38836090 4.647 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_+_85205417 4.423 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr6_-_60829826 4.038 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr11_-_95587691 3.628 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr8_-_57962564 3.538 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr10_+_80356459 3.470 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr2_-_162661075 3.395 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr18_-_34373313 3.260 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr3_-_89245159 3.245 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr6_-_118780324 2.855 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr5_-_18360384 2.847 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr3_-_89245005 2.842 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr7_-_12775658 2.836 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr18_+_37447641 2.833 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr17_+_43016536 2.628 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 6.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 6.1 GO:0099612 protein localization to axon(GO:0099612)
0.4 5.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 5.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 4.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.6 4.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.0 4.0 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
1.2 3.6 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 3.5 GO:0002347 response to tumor cell(GO:0002347)
0.7 2.9 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.7 2.8 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.9 2.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.3 2.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 2.0 GO:0038203 TORC2 signaling(GO:0038203)
0.0 2.0 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 1.8 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 1.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.4 1.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.4 1.3 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.5 6.1 GO:1990769 proximal neuron projection(GO:1990769)
0.3 5.3 GO:1990635 proximal dendrite(GO:1990635)
1.0 4.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 3.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 2.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.6 GO:0030424 axon(GO:0030424)
0.4 2.1 GO:0001533 cornified envelope(GO:0001533)
0.1 2.0 GO:0031932 TORC2 complex(GO:0031932)
0.4 1.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 1.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.9 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.7 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.4 GO:0003779 actin binding(GO:0003779)
0.4 7.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.9 5.3 GO:0050544 arachidonic acid binding(GO:0050544)
0.3 5.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 5.3 GO:0031489 myosin V binding(GO:0031489)
0.1 4.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 3.4 GO:0070097 delta-catenin binding(GO:0070097)
0.6 2.9 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.4 2.8 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 2.3 GO:0030246 carbohydrate binding(GO:0030246)
0.7 2.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 1.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.4 1.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.3 1.0 GO:0004875 complement receptor activity(GO:0004875)
0.2 0.9 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 4.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.6 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 2.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 0.9 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 0.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 5.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 3.6 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 3.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 2.8 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 2.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.3 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.9 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 0.6 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters