Motif ID: Pbx1_Pbx3

Z-value: 1.449

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx3mm10_v2_chr2_-_34372004_343720440.673.0e-08Click!
Pbx1mm10_v2_chr1_-_168432270_168432347-0.464.0e-04Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_15463837 19.218 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chrX_-_60893430 17.061 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr11_-_19018956 14.319 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr11_-_22001605 13.224 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr19_-_9899450 12.485 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr17_+_85620816 12.460 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr19_+_55741810 12.312 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_-_3938354 11.679 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr17_-_70853482 11.534 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr3_-_8667033 11.109 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr3_+_127633134 10.528 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr11_-_19018714 10.498 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr18_-_84086379 9.505 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr13_-_64153194 9.490 ENSMUST00000059817.4
ENSMUST00000117241.1
 Zfp367

zinc finger protein 367

chrX_+_58030622 8.933 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr14_-_122465677 8.260 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr2_-_36104060 8.199 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr10_-_42583628 8.114 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr17_+_85621017 8.022 ENSMUST00000162695.2
 Six3
sine oculis-related homeobox 3
chr4_+_11579647 7.915 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 26.8 GO:0048625 myoblast fate commitment(GO:0048625)
1.1 24.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.7 24.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
6.8 20.5 GO:0097402 neuroblast migration(GO:0097402)
2.4 19.5 GO:0048852 diencephalon morphogenesis(GO:0048852)
6.4 19.2 GO:0060364 frontal suture morphogenesis(GO:0060364)
3.1 18.7 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
0.8 17.1 GO:0007530 sex determination(GO:0007530)
0.8 12.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 12.4 GO:0055114 oxidation-reduction process(GO:0055114)
0.8 11.7 GO:0060736 prostate gland growth(GO:0060736)
0.0 10.7 GO:0007015 actin filament organization(GO:0007015)
0.1 10.3 GO:0000910 cytokinesis(GO:0000910)
3.2 9.5 GO:0060023 soft palate development(GO:0060023)
0.1 9.3 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
1.5 8.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.4 8.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.6 8.1 GO:0021764 amygdala development(GO:0021764)
0.2 7.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 6.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.8 GO:0005667 transcription factor complex(GO:0005667)
3.0 26.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.5 19.2 GO:0016592 mediator complex(GO:0016592)
1.4 18.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 17.3 GO:0016607 nuclear speck(GO:0016607)
0.1 16.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
4.2 12.5 GO:0000801 central element(GO:0000801)
0.9 7.8 GO:0072687 meiotic spindle(GO:0072687)
1.2 7.1 GO:0031262 Ndc80 complex(GO:0031262)
1.7 6.9 GO:0008623 CHRAC(GO:0008623)
1.3 6.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 6.4 GO:0005871 kinesin complex(GO:0005871)
0.1 5.3 GO:0016363 nuclear matrix(GO:0016363)
1.0 5.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 4.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 4.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 4.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.3 GO:0001726 ruffle(GO:0001726)
0.4 3.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 3.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 26.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 26.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 26.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 21.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.9 20.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.5 18.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 18.5 GO:0070888 E-box binding(GO:0070888)
1.1 16.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 15.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 11.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.7 11.5 GO:0070410 co-SMAD binding(GO:0070410)
3.7 11.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 11.0 GO:0016491 oxidoreductase activity(GO:0016491)
0.1 6.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 6.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 6.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 6.5 GO:0003777 microtubule motor activity(GO:0003777)
0.9 6.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
1.0 5.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 5.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 26.5 PID_PLK1_PATHWAY PLK1 signaling events
0.3 24.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 18.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 15.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 11.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 11.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 9.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 8.9 PID_ARF6_PATHWAY Arf6 signaling events
0.3 7.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 7.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 6.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.4 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 2.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 2.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 18.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.5 16.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 11.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 9.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 7.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 6.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 5.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 5.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 5.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 4.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 4.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 4.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 3.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 3.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation