Motif ID: Pbx2

Z-value: 0.595


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34592248_34592329-0.551.5e-05Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 6.446 ENSMUST00000100572.3
 Sla
src-like adaptor
chr3_+_121953213 4.748 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr15_+_21111452 3.809 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr11_-_110095937 3.382 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr1_-_56972437 3.131 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr2_+_65620829 2.984 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr6_+_8259288 2.700 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr13_-_113663670 2.667 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr2_-_104257400 2.613 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chrX_+_140367494 2.283 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr15_+_92597104 2.027 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr3_-_152982240 2.001 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr6_-_143947061 1.755 ENSMUST00000124233.1
 Sox5
SRY-box containing gene 5
chr6_+_8259327 1.713 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr5_+_106609098 1.689 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr3_+_68572245 1.630 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr6_+_8259379 1.582 ENSMUST00000162034.1
ENSMUST00000160705.1
ENSMUST00000159433.1
 Gm16039


predicted gene 16039


chr9_+_112234257 1.512 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr6_-_143947092 1.397 ENSMUST00000144289.1
ENSMUST00000111748.1
 Sox5

SRY-box containing gene 5

chr11_+_3330401 1.370 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 4.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.4 GO:0006869 lipid transport(GO:0006869)
0.4 3.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 3.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 2.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.6 GO:0001553 luteinization(GO:0001553)
0.0 1.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 1.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2 1.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 1.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 1.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 0.9 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.8 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.7 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 0.6 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 1.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)
0.0 0.8 GO:0043204 perikaryon(GO:0043204)
0.1 0.6 GO:0033269 internode region of axon(GO:0033269)
0.0 0.5 GO:0045298 tubulin complex(GO:0045298)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 3.0 GO:0030165 PDZ domain binding(GO:0030165)
0.9 2.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 2.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.2 GO:0051787 misfolded protein binding(GO:0051787)
0.3 1.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 1.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.8 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.2 0.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 3.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 0.9 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling