Motif ID: Pgr_Nr3c1

Z-value: 0.494

Transcription factors associated with Pgr_Nr3c1:

Gene SymbolEntrez IDGene Name
Nr3c1 ENSMUSG00000024431.8 Nr3c1
Pgr ENSMUSG00000031870.10 Pgr

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr3c1mm10_v2_chr18_-_39489880_39489915-0.066.8e-01Click!


Activity profile for motif Pgr_Nr3c1.

activity profile for motif Pgr_Nr3c1


Sorted Z-values histogram for motif Pgr_Nr3c1

Sorted Z-values for motif Pgr_Nr3c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pgr_Nr3c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 12.389 ENSMUST00000075312.3
 Ttr
transthyretin
chr13_-_84064772 3.935 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr10_+_97565436 3.897 ENSMUST00000038160.4
 Lum
lumican
chr4_-_136898803 1.629 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr5_+_24364804 1.533 ENSMUST00000030834.4
ENSMUST00000115090.1
 Nos3

nitric oxide synthase 3, endothelial cell

chr14_+_99298652 1.376 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr9_-_79718631 1.063 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr10_-_116473418 1.055 ENSMUST00000087965.4
ENSMUST00000164271.1
 Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4

chr14_+_70555900 0.955 ENSMUST00000163060.1
 Hr
hairless
chr13_+_29016267 0.921 ENSMUST00000140415.1
 A330102I10Rik
RIKEN cDNA A330102I10 gene
chr11_-_110168073 0.908 ENSMUST00000044850.3
 Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr13_+_91461050 0.889 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr5_-_104114088 0.885 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr9_-_79718518 0.878 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr14_-_16575456 0.846 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr11_+_111066154 0.803 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr9_-_79718720 0.771 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr2_-_122611238 0.767 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_-_127824469 0.764 ENSMUST00000106267.3
 Stx1b
syntaxin 1B
chr2_+_65620829 0.762 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 12.4 GO:0070327 thyroid hormone transport(GO:0070327)
1.0 3.9 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 1.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 1.5 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.2 1.5 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 1.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 0.8 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 0.8 GO:1904048 negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.1 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.8 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.3 0.7 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 0.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.5 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.5 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.4 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.1 GO:0005615 extracellular space(GO:0005615)
0.3 3.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 2.7 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.1 0.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.1 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 4.8 GO:0005518 collagen binding(GO:0005518)
0.5 1.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.8 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.8 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.2 0.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.4 3.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 1.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.2 REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions