Motif ID: Pitx1

Z-value: 0.697


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 197 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_93913678 5.509 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_-_97747373 4.060 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 3.937 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_46010212 3.582 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_-_155232710 3.510 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr10_-_92165159 3.451 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr7_-_4752972 3.204 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_+_127064022 3.164 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr5_+_3343893 3.143 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr8_+_127063893 3.059 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr17_+_75005523 2.992 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr14_-_118052235 2.970 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr5_+_3344194 2.926 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr2_+_102658640 2.908 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_41697040 2.725 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr14_-_54926784 2.722 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr14_-_31640878 2.674 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr14_+_26122609 2.470 ENSMUST00000100810.6
 Duxbl2
doubl homeobox B-like 2
chr4_+_116708687 2.453 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_-_155010984 2.448 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0016042 lipid catabolic process(GO:0016042)
1.0 6.2 GO:0003383 apical constriction(GO:0003383)
0.9 6.1 GO:0044838 cell quiescence(GO:0044838)
0.5 5.9 GO:0042572 retinol metabolic process(GO:0042572)
0.5 3.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 3.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 2.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.7 2.7 GO:0003360 brainstem development(GO:0003360)
0.5 2.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 2.7 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.8 2.4 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.2 2.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 2.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 2.2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.4 2.1 GO:0061642 chemoattraction of axon(GO:0061642)
0.0 2.0 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.4 1.9 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.4 1.8 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087)
0.2 1.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.5 GO:0040034 regulation of development, heterochronic(GO:0040034)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 6.2 GO:0033269 internode region of axon(GO:0033269)
0.0 5.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 3.2 GO:0030061 mitochondrial crista(GO:0030061)
1.0 3.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 3.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 2.9 GO:0030673 axolemma(GO:0030673)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.9 2.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 2.7 GO:0010369 chromocenter(GO:0010369)
0.1 2.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.9 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 1.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.8 GO:0030425 dendrite(GO:0030425)
0.2 1.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.7 GO:0035253 ciliary rootlet(GO:0035253)
0.5 1.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.2 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
2.0 6.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.3 5.5 GO:0051393 alpha-actinin binding(GO:0051393)
0.7 5.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 3.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.1 GO:0005112 Notch binding(GO:0005112)
0.7 3.0 GO:0050436 microfibril binding(GO:0050436)
0.2 3.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 2.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.7 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 2.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.3 2.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 2.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.3 GO:0030332 cyclin binding(GO:0030332)
0.5 2.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.2 1.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 6.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 5.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 1.8 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 1.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.5 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 1.0 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 6.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 3.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.8 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 2.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 2.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 1.8 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 1.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.0 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 0.9 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins