Motif ID: Pitx2_Otx2

Z-value: 1.599

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48665098_486652460.601.1e-06Click!
Pitx2mm10_v2_chr3_+_129213920_1292139380.367.5e-03Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_75782080 21.811 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr6_-_88898664 18.552 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr2_+_164562579 14.197 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr9_-_70421533 14.109 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr11_-_106998483 14.048 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr4_-_117182623 13.348 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr14_-_47411666 10.731 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_34751803 10.470 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr17_+_35861318 10.126 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr14_-_20181773 9.543 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr16_+_30065333 9.214 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_+_119357381 9.209 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr18_-_74207771 9.050 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr14_-_47418407 8.901 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_97029925 8.418 ENSMUST00000021249.4
 Scrn2
secernin 2
chr3_-_36571952 8.279 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr14_+_55824795 8.221 ENSMUST00000024179.5
ENSMUST00000172271.1
 Nfatc4

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

chr7_+_16992708 7.933 ENSMUST00000094805.4
 Ccdc8
coiled-coil domain containing 8
chr10_-_128180265 7.585 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr1_-_175979114 7.432 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 24.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.5 19.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.9 18.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 16.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
2.7 13.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
4.1 12.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
4.0 12.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.3 11.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.4 11.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 11.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 11.1 GO:0031109 microtubule polymerization or depolymerization(GO:0031109)
0.2 10.9 GO:0043029 T cell homeostasis(GO:0043029)
1.0 9.5 GO:0030322 stabilization of membrane potential(GO:0030322)
3.1 9.2 GO:0021557 oculomotor nerve development(GO:0021557)
2.3 9.0 GO:0006545 glycine biosynthetic process(GO:0006545)
1.0 8.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.9 8.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 8.3 GO:0016572 histone phosphorylation(GO:0016572)
0.1 8.3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
2.7 8.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 35.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 23.6 GO:0005643 nuclear pore(GO:0005643)
0.1 23.3 GO:0016607 nuclear speck(GO:0016607)
2.7 21.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 21.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.2 19.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 16.8 GO:0070469 respiratory chain(GO:0070469)
1.0 16.7 GO:0005652 nuclear lamina(GO:0005652)
0.3 16.0 GO:0005871 kinesin complex(GO:0005871)
2.0 14.1 GO:0001940 male pronucleus(GO:0001940)
0.1 11.7 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 10.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 10.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 10.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.7 9.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 8.9 GO:0031527 filopodium membrane(GO:0031527)
0.9 8.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.3 7.9 GO:1990393 3M complex(GO:1990393)
0.1 7.2 GO:0000776 kinetochore(GO:0000776)
0.2 7.1 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 271 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 54.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 22.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.3 18.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 18.6 GO:0045296 cadherin binding(GO:0045296)
1.2 18.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 15.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
2.8 14.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.7 12.3 GO:0051010 microtubule plus-end binding(GO:0051010)
4.1 12.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.7 10.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.9 9.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 9.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 9.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 9.2 GO:0008432 JUN kinase binding(GO:0008432)
3.0 9.0 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 8.6 GO:0003774 motor activity(GO:0003774)
0.0 8.6 GO:0005198 structural molecule activity(GO:0005198)
0.1 8.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 8.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6 8.4 GO:0016805 dipeptidase activity(GO:0016805)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 32.9 PID_ATR_PATHWAY ATR signaling pathway
0.8 24.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 23.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 20.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 15.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 14.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 12.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 11.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 9.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 8.8 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 8.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 7.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 5.7 PID_E2F_PATHWAY E2F transcription factor network
0.2 5.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 4.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 4.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.5 4.7 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 4.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 50.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.3 23.7 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.3 22.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.3 20.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 19.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 19.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.3 17.7 REACTOME_SYNTHESIS_OF_DNA Genes involved in Synthesis of DNA
0.6 17.3 REACTOME_KINESINS Genes involved in Kinesins
0.2 15.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 14.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 11.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 10.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.6 9.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 9.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.7 8.9 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.4 8.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 8.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 7.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 6.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 6.0 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA