Motif ID: Pitx3
Z-value: 0.811
Transcription factors associated with Pitx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pitx3 | ENSMUSG00000025229.9 | Pitx3 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 163 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.4 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.1 | 5.3 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.0 | 3.9 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.8 | 3.3 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.6 | 3.0 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.1 | 2.9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.6 | 2.5 | GO:1990743 | protein sialylation(GO:1990743) |
| 0.4 | 2.4 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.2 | 2.3 | GO:0097502 | mannosylation(GO:0097502) |
| 0.3 | 2.2 | GO:0044838 | germ-line stem cell population maintenance(GO:0030718) cell quiescence(GO:0044838) |
| 0.1 | 2.2 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.0 | 2.1 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.4 | 2.0 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.6 | 1.9 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.6 | 1.9 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.6 | 1.9 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.1 | 1.9 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 1.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.5 | 1.8 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
| 0.2 | 1.8 | GO:0060613 | fat pad development(GO:0060613) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 77 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0000802 | transverse filament(GO:0000802) |
| 0.1 | 3.0 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 2.5 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 2.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 1.8 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 1.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 1.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 1.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.3 | GO:0090576 | RNA polymerase III transcription factor complex(GO:0090576) |
| 0.1 | 1.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.2 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.4 | 1.1 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.2 | 1.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.0 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.0 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 1.0 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 110 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.4 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.9 | 5.3 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 3.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 3.0 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.1 | 2.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.4 | 2.5 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.5 | 2.3 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 2.3 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 2.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.2 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.5 | 1.9 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 1.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 1.9 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.2 | 1.8 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.0 | 1.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.6 | 1.7 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.1 | 1.6 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 1.6 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.3 | 1.4 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.1 | 1.4 | GO:0008373 | sialyltransferase activity(GO:0008373) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 25 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 2.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.2 | 1.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.8 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 1.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.3 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.3 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.2 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.0 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.0 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.8 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.8 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 0.7 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 0.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 0.6 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 0.6 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 4.8 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 4.1 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 3.2 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.3 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 2.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.9 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.7 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.6 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 1.4 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.2 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.1 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.0 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 0.9 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 0.9 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
