Motif ID: Pknox2_Pknox1

Z-value: 0.941

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.321.7e-02Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.029.1e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 8.197 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr2_+_105682463 7.904 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_-_34913976 7.225 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr11_-_114795888 6.337 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr7_-_48881032 6.120 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr9_+_44134562 5.599 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr11_+_78324200 5.470 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr8_-_61902669 5.348 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr19_-_9899450 5.095 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr17_-_70851710 4.631 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr13_-_58274121 4.325 ENSMUST00000091579.4
 Gkap1
G kinase anchoring protein 1
chr18_+_56432116 3.620 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr7_-_131410325 3.544 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr7_-_131410495 3.518 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr10_+_41810528 3.126 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr4_-_3938354 2.780 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr5_-_134747241 2.754 ENSMUST00000015138.9
 Eln
elastin
chrX_-_109013389 2.745 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chrX_-_60893430 2.740 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr9_+_113930934 2.664 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.9 8.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.6 7.9 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.0 7.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 7.1 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 5.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 5.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 5.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 5.1 GO:0000910 cytokinesis(GO:0000910)
0.0 4.3 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.2 3.4 GO:0060736 prostate gland growth(GO:0060736)
0.2 3.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.4 3.0 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.0 2.8 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 2.7 GO:0007530 sex determination(GO:0007530)
0.0 2.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.9 2.6 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.4 2.6 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 2.5 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 2.4 GO:0008542 visual learning(GO:0008542)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.6 GO:0005654 nucleoplasm(GO:0005654)
0.0 15.0 GO:0005667 transcription factor complex(GO:0005667)
0.3 7.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 5.3 GO:0002102 podosome(GO:0002102)
1.7 5.1 GO:0000801 central element(GO:0000801)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.9 2.8 GO:0071953 elastic fiber(GO:0071953)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 2.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 1.0 GO:0001740 Barr body(GO:0001740)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 1.0 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.8 GO:0098536 deuterosome(GO:0098536)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.6 GO:0035749 myelin sheath adaxonal region(GO:0035749)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.7 GO:0070410 co-SMAD binding(GO:0070410)
0.1 18.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 7.2 GO:0035064 methylated histone binding(GO:0035064)
0.9 5.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 3.6 GO:0020037 heme binding(GO:0020037)
0.5 3.1 GO:0070728 leucine binding(GO:0070728)
0.1 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 2.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.3 2.6 GO:0036122 BMP binding(GO:0036122)
0.1 2.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.6 2.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 1.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.3 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.2 1.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.0 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 7.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 5.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 5.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 2.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.3 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.1 1.2 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network