Motif ID: Plag1

Z-value: 0.557


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.019.2e-01Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 1.825 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr4_-_133498538 1.475 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr5_+_117841839 1.244 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr4_-_129121699 1.151 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr11_-_69369377 1.039 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr3_+_89520152 1.002 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr11_+_77930800 0.974 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr5_+_117781017 0.946 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr15_-_66801577 0.802 ENSMUST00000168589.1
 Sla
src-like adaptor
chr7_-_46099752 0.798 ENSMUST00000180081.1
 Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
chr17_-_87797994 0.786 ENSMUST00000055221.7
 Kcnk12
potassium channel, subfamily K, member 12
chr19_-_42431778 0.767 ENSMUST00000048630.6
 Crtac1
cartilage acidic protein 1
chr7_-_46179929 0.762 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr4_-_129121234 0.741 ENSMUST00000030572.3
 Hpca
hippocalcin
chr6_-_48841373 0.739 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr5_-_89883321 0.671 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr11_-_95587691 0.667 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr4_-_129121889 0.665 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr2_+_91945703 0.642 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr6_-_48841098 0.623 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.0 2.4 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
0.7 2.2 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 1.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 1.6 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 1.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.1 GO:0033198 response to ATP(GO:0033198)
0.1 1.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 0.8 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.1 0.8 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 0.8 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.8 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.8 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.2 0.7 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.2 0.6 GO:0016115 terpenoid catabolic process(GO:0016115)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0044327 dendritic spine head(GO:0044327)
0.2 2.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.9 GO:0031594 neuromuscular junction(GO:0031594)
0.4 1.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.7 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.2 0.6 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 0.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.5 GO:0061702 inflammasome complex(GO:0061702)
0.1 0.5 GO:0008091 spectrin(GO:0008091)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.6 1.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 1.1 GO:0019841 retinol binding(GO:0019841)
0.3 1.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.8 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.8 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 0.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.7 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 0.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.6 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.1 0.5 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 0.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.0 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.7 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix