Motif ID: Plagl1

Z-value: 0.591


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.719.8e-10Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_91807424 6.051 ENSMUST00000162300.1
 Grip2
glutamate receptor interacting protein 2
chr2_-_104257400 5.987 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr6_-_91807318 5.441 ENSMUST00000159684.1
 Grip2
glutamate receptor interacting protein 2
chr4_+_152338619 5.023 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr17_+_46297406 4.966 ENSMUST00000061722.6
ENSMUST00000166280.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr5_-_139130159 3.741 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_+_26331150 3.648 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr4_+_47288057 3.396 ENSMUST00000140413.1
ENSMUST00000107731.2
 Col15a1

collagen, type XV, alpha 1

chr17_+_46297917 3.278 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr17_-_24644933 3.060 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr19_+_6497772 3.037 ENSMUST00000113458.1
ENSMUST00000113459.1
 Nrxn2

neurexin II

chr10_-_81482655 2.881 ENSMUST00000120508.1
ENSMUST00000118763.1
 Celf5

CUGBP, Elav-like family member 5

chr11_-_120047144 2.577 ENSMUST00000103020.1
 Aatk
apoptosis-associated tyrosine kinase
chr10_+_38965515 2.505 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr7_-_99695809 2.439 ENSMUST00000107086.2
 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr6_+_110645572 2.388 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr9_+_75625707 2.284 ENSMUST00000034702.4
 Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr11_+_98741871 2.239 ENSMUST00000103139.4
 Thra
thyroid hormone receptor alpha
chr4_+_47288287 2.162 ENSMUST00000146967.1
 Col15a1
collagen, type XV, alpha 1
chr11_+_98741805 2.103 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.5 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.2 8.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.7 5.0 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 4.8 GO:0071625 vocalization behavior(GO:0071625)
1.4 4.3 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.3 3.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 3.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 2.9 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 2.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.5 2.6 GO:0046684 response to pyrethroid(GO:0046684)
0.2 2.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 2.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 2.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 2.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 2.1 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.1 2.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 2.1 GO:0016236 macroautophagy(GO:0016236)
0.2 2.0 GO:0043589 skin morphogenesis(GO:0043589)
0.3 1.9 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 1.8 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.2 5.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.8 GO:0009925 basal plasma membrane(GO:0009925)
0.3 3.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 3.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 3.4 GO:0014069 postsynaptic density(GO:0014069)
0.1 3.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.9 GO:0032420 stereocilium(GO:0032420)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 2.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.5 GO:0005605 basal lamina(GO:0005605)
0.2 2.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.7 2.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 1.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.0 1.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 1.5 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 7.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 7.1 GO:0005509 calcium ion binding(GO:0005509)
1.3 5.0 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.4 4.3 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.3 3.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 3.1 GO:0016151 nickel cation binding(GO:0016151)
0.1 3.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 3.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 2.6 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.8 2.4 GO:0070905 serine binding(GO:0070905)
0.3 2.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.7 2.1 GO:0016015 morphogen activity(GO:0016015)
0.1 2.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 1.7 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.4 1.6 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 1.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 3.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 5.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 2.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 2.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.1 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.2 2.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 0.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane