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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: Plagl1

Z-value: 0.591

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_91807424	6.051	ENSMUST00000162300.1	Grip2	glutamate receptor interacting protein 2
chr2_-_104257400	5.987	ENSMUST00000141159.1	D430041D05Rik	RIKEN cDNA D430041D05 gene
chr6_-_91807318	5.441	ENSMUST00000159684.1	Grip2	glutamate receptor interacting protein 2
chr4_+_152338619	5.023	ENSMUST00000030775.5 ENSMUST00000164662.1	Chd5	chromodomain helicase DNA binding protein 5
chr17_+_46297406	4.966	ENSMUST00000061722.6 ENSMUST00000166280.1	Dlk2	delta-like 2 homolog (Drosophila)
chr5_-_139130159	3.741	ENSMUST00000129851.1	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta
chr3_+_26331150	3.648	ENSMUST00000099182.2	A830092H15Rik	RIKEN cDNA A830092H15 gene
chr4_+_47288057	3.396	ENSMUST00000140413.1 ENSMUST00000107731.2	Col15a1	collagen, type XV, alpha 1
chr17_+_46297917	3.278	ENSMUST00000166617.1 ENSMUST00000170271.1	Dlk2	delta-like 2 homolog (Drosophila)
chr17_-_24644933	3.060	ENSMUST00000019684.5	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr19_+_6497772	3.037	ENSMUST00000113458.1 ENSMUST00000113459.1	Nrxn2	neurexin II
chr10_-_81482655	2.881	ENSMUST00000120508.1 ENSMUST00000118763.1	Celf5	CUGBP, Elav-like family member 5
chr11_-_120047144	2.577	ENSMUST00000103020.1	Aatk	apoptosis-associated tyrosine kinase
chr10_+_38965515	2.505	ENSMUST00000019992.5	Lama4	laminin, alpha 4
chr7_-_99695809	2.439	ENSMUST00000107086.2	Slco2b1	solute carrier organic anion transporter family, member 2b1
chr6_+_110645572	2.388	ENSMUST00000071076.6 ENSMUST00000172951.1	Grm7	glutamate receptor, metabotropic 7
chr9_+_75625707	2.284	ENSMUST00000034702.4	Lysmd2	LysM, putative peptidoglycan-binding, domain containing 2
chr11_+_98741871	2.239	ENSMUST00000103139.4	Thra	thyroid hormone receptor alpha
chr4_+_47288287	2.162	ENSMUST00000146967.1	Col15a1	collagen, type XV, alpha 1
chr11_+_98741805	2.103	ENSMUST00000064187.5	Thra	thyroid hormone receptor alpha
chr4_-_139092958	2.070	ENSMUST00000042844.6	Nbl1	neuroblastoma, suppression of tumorigenicity 1
chr15_-_43869993	2.058	ENSMUST00000067469.4	Tmem74	transmembrane protein 74
chr6_+_4504814	2.015	ENSMUST00000141483.1	Col1a2	collagen, type I, alpha 2
chr6_-_128200598	1.997	ENSMUST00000071101.6	Gm10010	predicted gene 10010
chr4_+_101496648	1.870	ENSMUST00000106930.1 ENSMUST00000154120.1	Dnajc6	DnaJ (Hsp40) homolog, subfamily C, member 6
chr18_+_32377176	1.833	ENSMUST00000091967.5 ENSMUST00000025239.7	Bin1	bridging integrator 1
chr11_+_70018421	1.740	ENSMUST00000108588.1	Dlg4	discs, large homolog 4 (Drosophila)
chr13_+_5861489	1.735	ENSMUST00000000080.6	Klf6	Kruppel-like factor 6
chr5_-_34187670	1.688	ENSMUST00000042701.6 ENSMUST00000119171.1	Mxd4	Max dimerization protein 4
chr3_-_108017877	1.629	ENSMUST00000004140.4	Gstm1	glutathione S-transferase, mu 1
chr5_-_136567242	1.617	ENSMUST00000175975.2 ENSMUST00000176216.2 ENSMUST00000176745.1	Cux1	cut-like homeobox 1
chr5_+_125475814	1.607	ENSMUST00000031445.3	Aacs	acetoacetyl-CoA synthetase
chr10_-_81014902	1.599	ENSMUST00000126317.1 ENSMUST00000092285.3 ENSMUST00000117805.1	Gng7	guanine nucleotide binding protein (G protein), gamma 7
chr6_-_92481343	1.562	ENSMUST00000113445.1	Prickle2	prickle homolog 2 (Drosophila)
chr19_+_45047557	1.525	ENSMUST00000062213.5 ENSMUST00000111954.4 ENSMUST00000084493.6	Sfxn3	sideroflexin 3
chr7_+_142533012	1.513	ENSMUST00000038675.6	Mrpl23	mitochondrial ribosomal protein L23
chrX_-_73824938	1.510	ENSMUST00000114438.2 ENSMUST00000002080.5	Pdzd4	PDZ domain containing 4
chr17_+_25016343	1.490	ENSMUST00000024983.5	Ift140	intraflagellar transport 140
chr4_+_129136948	1.487	ENSMUST00000102600.3	Fndc5	fibronectin type III domain containing 5
chr3_-_108017806	1.483	ENSMUST00000126593.1	Gstm1	glutathione S-transferase, mu 1
chr6_-_128143525	1.462	ENSMUST00000032503.5 ENSMUST00000112173.1	Tspan9	tetraspanin 9
chr2_-_65567465	1.399	ENSMUST00000066432.5	Scn3a	sodium channel, voltage-gated, type III, alpha
chr2_-_132145057	1.341	ENSMUST00000028815.8	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2
chr19_+_4711153	1.236	ENSMUST00000008991.6	Sptbn2	spectrin beta, non-erythrocytic 2
chr2_-_65567505	1.201	ENSMUST00000100069.2	Scn3a	sodium channel, voltage-gated, type III, alpha
chr5_-_92083455	1.169	ENSMUST00000169094.1 ENSMUST00000167918.1	G3bp2	GTPase activating protein (SH3 domain) binding protein 2
chr8_+_93810832	1.057	ENSMUST00000034198.8 ENSMUST00000125716.1	Gnao1	guanine nucleotide binding protein, alpha O
chr12_+_100199435	1.049	ENSMUST00000110082.3	Calm1	calmodulin 1
chr18_-_38601268	1.048	ENSMUST00000025295.6	Spry4	sprouty homolog 4 (Drosophila)
chr1_-_120074023	0.993	ENSMUST00000056089.7	Tmem37	transmembrane protein 37
chr2_-_130642770	0.990	ENSMUST00000045761.6	Lzts3	leucine zipper, putative tumor suppressor family member 3
chr5_-_92083667	0.978	ENSMUST00000113127.3	G3bp2	GTPase activating protein (SH3 domain) binding protein 2
chr12_+_110889231	0.975	ENSMUST00000169597.1 ENSMUST00000165978.1	Tecpr2	tectonin beta-propeller repeat containing 2
chr11_+_32455362	0.967	ENSMUST00000051053.4	Ubtd2	ubiquitin domain containing 2
chr1_-_179546261	0.916	ENSMUST00000027769.5	Tfb2m	transcription factor B2, mitochondrial
chr1_-_88205674	0.907	ENSMUST00000119972.2	Dnajb3	DnaJ (Hsp40) homolog, subfamily B, member 3
chr1_+_179546303	0.882	ENSMUST00000040706.8	Cnst	consortin, connexin sorting protein
chr12_-_103443653	0.853	ENSMUST00000055071.8	Ifi27l2a	interferon, alpha-inducible protein 27 like 2A
chr12_-_69893162	0.805	ENSMUST00000049239.7 ENSMUST00000110570.1	Map4k5	mitogen-activated protein kinase kinase kinase kinase 5
chrX_+_163911401	0.789	ENSMUST00000140845.1	Ap1s2	adaptor-related protein complex 1, sigma 2 subunit
chr2_-_152831112	0.789	ENSMUST00000128172.1	Bcl2l1	BCL2-like 1
chr10_-_95415484	0.768	ENSMUST00000172070.1 ENSMUST00000150432.1	Socs2	suppressor of cytokine signaling 2
chr10_-_70599284	0.761	ENSMUST00000046513.3	Phyhipl	phytanoyl-CoA hydroxylase interacting protein-like
chr6_+_40325471	0.743	ENSMUST00000031977.8	Agk	acylglycerol kinase
chr6_+_83179568	0.739	ENSMUST00000113919.3 ENSMUST00000113918.1 ENSMUST00000141680.1	Dctn1	dynactin 1
chr2_-_152332639	0.728	ENSMUST00000028964.7	Rbck1	RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_15816762	0.727	ENSMUST00000020922.7	Trib2	tribbles homolog 2 (Drosophila)
chr14_+_64588112	0.716	ENSMUST00000181808.1	A930011O12Rik	RIKEN cDNA A930011O12 gene
chr16_+_32277449	0.705	ENSMUST00000155649.1 ENSMUST00000014218.8 ENSMUST00000171474.1	Rnf168	ring finger protein 168
chr2_+_25428699	0.689	ENSMUST00000102919.3	Abca2	ATP-binding cassette, sub-family A (ABC1), member 2
chr5_-_136883115	0.686	ENSMUST00000057497.6 ENSMUST00000111103.1	Col26a1	collagen, type XXVI, alpha 1
chr1_+_74588347	0.632	ENSMUST00000113732.1	Bcs1l	BCS1-like (yeast)
chr2_-_18998126	0.628	ENSMUST00000006912.5	Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr2_-_39190687	0.611	ENSMUST00000142872.1 ENSMUST00000038874.5	Scai	suppressor of cancer cell invasion
chr8_-_25101985	0.609	ENSMUST00000128715.1 ENSMUST00000064883.6	Plekha2	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr5_+_24393640	0.604	ENSMUST00000138168.1 ENSMUST00000115077.1	Abcb8	ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr1_+_74588289	0.572	ENSMUST00000113733.3 ENSMUST00000027358.4	Bcs1l	BCS1-like (yeast)
chr16_-_34262830	0.558	ENSMUST00000114947.1	Kalrn	kalirin, RhoGEF kinase
chr11_+_67966442	0.501	ENSMUST00000021286.4 ENSMUST00000108675.1	Stx8	syntaxin 8
chr2_-_3419019	0.453	ENSMUST00000115084.1 ENSMUST00000115083.1	Meig1	meiosis expressed gene 1
chrX_+_99821021	0.433	ENSMUST00000096363.2	Tmem28	transmembrane protein 28
chr4_+_106561027	0.427	ENSMUST00000047973.3	Dhcr24	24-dehydrocholesterol reductase
chr5_-_143269958	0.423	ENSMUST00000161448.1	Zfp316	zinc finger protein 316
chr17_+_29549783	0.390	ENSMUST00000048677.7	Tbc1d22b	TBC1 domain family, member 22B
chr8_-_40634776	0.389	ENSMUST00000048898.10 ENSMUST00000174205.1	Mtmr7	myotubularin related protein 7
chr2_-_152830615	0.384	ENSMUST00000146380.1 ENSMUST00000134902.1 ENSMUST00000134357.1 ENSMUST00000109820.3	Bcl2l1	BCL2-like 1
chr10_-_95415283	0.369	ENSMUST00000119917.1	Socs2	suppressor of cytokine signaling 2
chr8_-_40634750	0.361	ENSMUST00000173957.1	Mtmr7	myotubularin related protein 7
chr9_+_46273064	0.342	ENSMUST00000156440.1 ENSMUST00000034583.6 ENSMUST00000114552.3	Zfp259	zinc finger protein 259
chr1_+_134455524	0.341	ENSMUST00000112232.1 ENSMUST00000027725.4 ENSMUST00000116528.1	Klhl12	kelch-like 12
chr4_+_155249960	0.306	ENSMUST00000178473.1 ENSMUST00000105627.1 ENSMUST00000097747.2	2610002J02Rik	RIKEN cDNA 2610002J02 gene
chr17_+_29660710	0.284	ENSMUST00000130423.1	Cmtr1	cap methyltransferase 1
chr9_+_108662098	0.283	ENSMUST00000035222.5	Slc25a20	solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr9_-_59486610	0.278	ENSMUST00000171975.1	Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr2_-_3419066	0.254	ENSMUST00000115082.3	Meig1	meiosis expressed gene 1
chr11_+_95010277	0.252	ENSMUST00000124735.1	Samd14	sterile alpha motif domain containing 14
chr6_-_48086530	0.248	ENSMUST00000073124.6	Zfp746	zinc finger protein 746
chr4_-_22488296	0.200	ENSMUST00000178174.1	Pou3f2	POU domain, class 3, transcription factor 2
chr6_+_42286709	0.166	ENSMUST00000163936.1	Clcn1	chloride channel 1
chr2_+_174076296	0.153	ENSMUST00000155000.1 ENSMUST00000134876.1 ENSMUST00000147038.1	Stx16	syntaxin 16
chr10_+_128377086	0.151	ENSMUST00000014642.3	Ankrd52	ankyrin repeat domain 52
chr15_+_75993756	0.146	ENSMUST00000089669.4	Mapk15	mitogen-activated protein kinase 15
chr8_-_13974715	0.130	ENSMUST00000119182.1 ENSMUST00000062613.4	Tdrp	testis development related protein
chr17_-_25868727	0.130	ENSMUST00000026828.5	Fam195a	family with sequence similarity 195, member A
chr12_+_33147754	0.124	ENSMUST00000146040.1 ENSMUST00000125192.1	Atxn7l1	ataxin 7-like 1
chrX_-_37085402	0.110	ENSMUST00000115231.3	Rpl39	ribosomal protein L39
chr10_+_80016901	0.105	ENSMUST00000105373.1	Hmha1	histocompatibility (minor) HA-1
chr17_+_37193889	0.081	ENSMUST00000038844.6	Ubd	ubiquitin D
chr7_+_45872772	0.079	ENSMUST00000002855.5 ENSMUST00000107719.1	Kdelr1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr16_+_32099781	0.064	ENSMUST00000115168.2	Cep19	centrosomal protein 19
chr7_+_5015466	0.060	ENSMUST00000086349.3	Zfp524	zinc finger protein 524
chr19_-_4625612	0.046	ENSMUST00000025823.3	Rce1	RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr6_-_134887783	0.019	ENSMUST00000066107.6	Gpr19	G protein-coupled receptor 19

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.3	GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
1.1	11.5	GO:0014824	artery smooth muscle contraction(GO:0014824)
0.7	5.0	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5	1.6	GO:0001830	trophectodermal cell fate commitment(GO:0001830)
0.5	2.6	GO:0046684	response to pyrethroid(GO:0046684)
0.5	2.1	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.5	2.4	GO:0001661	conditioned taste aversion(GO:0001661)
0.4	1.3	GO:0015882	L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.3	3.7	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3	1.9	GO:0072318	clathrin coat disassembly(GO:0072318)
0.3	0.9	GO:0090004	positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.3	1.2	GO:0046898	response to cycloheximide(GO:0046898)
0.2	0.7	GO:0070535	histone H2A K63-linked ubiquitination(GO:0070535)
0.2	2.6	GO:0032482	Rab protein signal transduction(GO:0032482)
0.2	2.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.2	8.2	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.2	1.5	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.2	3.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.2	1.5	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.2	1.6	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2	2.0	GO:0043589	skin morphogenesis(GO:0043589)
0.2	4.8	GO:0071625	vocalization behavior(GO:0071625)
0.1	0.7	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.1	1.8	GO:0048711	positive regulation of astrocyte differentiation(GO:0048711)
0.1	2.9	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1	1.2	GO:0034551	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1	0.9	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
0.1	0.7	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.1	0.7	GO:0032380	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1	0.3	GO:0097309	cap1 mRNA methylation(GO:0097309)
0.1	2.5	GO:0050873	brown fat cell differentiation(GO:0050873)
0.1	2.1	GO:0034063	stress granule assembly(GO:0034063)
0.1	0.6	GO:0060125	negative regulation of growth hormone secretion(GO:0060125) maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1	0.7	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.1	0.6	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.1	0.4	GO:0098703	calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1	1.2	GO:0021692	cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1	1.1	GO:0071378	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1	0.7	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.1	2.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.3	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.3	GO:0015879	carnitine transport(GO:0015879)
0.0	0.4	GO:0031639	plasminogen activation(GO:0031639)
0.0	1.6	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	1.6	GO:0070542	response to fatty acid(GO:0070542)
0.0	1.1	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.6	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	1.5	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.7	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.8	GO:0060612	adipose tissue development(GO:0060612)
0.0	1.5	GO:0055072	iron ion homeostasis(GO:0055072)
0.0	1.0	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.2	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.0	1.0	GO:0043407	negative regulation of MAP kinase activity(GO:0043407)
0.0	0.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.6	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.5	GO:0045022	early endosome to late endosome transport(GO:0045022)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.7	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.2	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	2.1	GO:0016236	macroautophagy(GO:0016236)
0.0	0.1	GO:0002227	innate immune response in mucosa(GO:0002227)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.0	GO:0005584	collagen type I trimer(GO:0005584)
0.3	3.7	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	2.4	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.2	5.0	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	1.2	GO:0008091	spectrin(GO:0008091)
0.2	0.7	GO:0071797	LUBAC complex(GO:0071797)
0.2	2.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.2	1.5	GO:0030991	intraciliary transport particle A(GO:0030991)
0.2	3.4	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.2	1.5	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	2.5	GO:0005605	basal lamina(GO:0005605)
0.1	1.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.1	11.5	GO:0043198	dendritic shaft(GO:0043198)
0.1	6.2	GO:0005581	collagen trimer(GO:0005581)
0.1	1.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	2.9	GO:0032420	stereocilium(GO:0032420)
0.1	3.8	GO:0009925	basal plasma membrane(GO:0009925)
0.1	2.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	0.7	GO:0005869	dynactin complex(GO:0005869)
0.1	3.0	GO:0042734	presynaptic membrane(GO:0042734)
0.0	1.8	GO:0044295	axonal growth cone(GO:0044295)
0.0	1.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.3	GO:0097413	Lewy body(GO:0097413)
0.0	1.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.7	GO:0035861	site of double-strand break(GO:0035861)
0.0	0.9	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	1.5	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	0.7	GO:0031201	SNARE complex(GO:0031201)
0.0	3.4	GO:0014069	postsynaptic density(GO:0014069)
0.0	0.8	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.9	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.8	GO:0001650	fibrillar center(GO:0001650)
0.0	1.7	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.3	GO:0002153	steroid receptor RNA activator RNA binding(GO:0002153)
1.3	5.0	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
0.8	2.4	GO:0070905	serine binding(GO:0070905)
0.7	2.1	GO:0016015	morphogen activity(GO:0016015)
0.4	1.3	GO:0070890	L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.4	1.6	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.3	2.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.3	3.7	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3	3.1	GO:0016151	nickel cation binding(GO:0016151)
0.3	1.0	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.2	0.7	GO:0001729	ceramide kinase activity(GO:0001729)
0.2	0.9	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2	1.1	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.2	1.7	GO:0031811	G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2	0.6	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2	1.1	GO:0051429	corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1	0.4	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1	2.6	GO:0031402	sodium ion binding(GO:0031402)
0.1	11.5	GO:0035254	glutamate receptor binding(GO:0035254)
0.1	2.0	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	1.2	GO:0051434	BH3 domain binding(GO:0051434)
0.1	0.9	GO:0071253	connexin binding(GO:0071253)
0.1	0.7	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	3.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.1	0.5	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.1	0.3	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1	0.3	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1	3.0	GO:0005246	calcium channel regulator activity(GO:0005246)
0.1	0.8	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	1.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.7	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	1.6	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.7	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.6	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	1.5	GO:0005179	hormone activity(GO:0005179)
0.0	1.0	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.4	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0	0.6	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	2.6	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.0	1.0	GO:0043621	protein self-association(GO:0043621)
0.0	1.9	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	1.0	GO:0005262	calcium channel activity(GO:0005262)
0.0	7.1	GO:0005509	calcium ion binding(GO:0005509)
0.0	7.2	GO:0005198	structural molecule activity(GO:0005198)
0.0	0.7	GO:0005080	protein kinase C binding(GO:0005080)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.1	NABA_BASEMENT_MEMBRANES	Genes encoding structural components of basement membranes
0.1	4.3	PID_RXR_VDR_PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	2.7	NABA_COLLAGENS	Genes encoding collagen proteins
0.1	3.7	PID_INTEGRIN_A4B1_PATHWAY	Alpha4 beta1 integrin signaling events
0.1	1.1	PID_S1P_S1P4_PATHWAY	S1P4 pathway
0.1	1.7	ST_GA12_PATHWAY	G alpha 12 Pathway
0.1	1.2	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	3.1	PID_LYSOPHOSPHOLIPID_PATHWAY	LPA receptor mediated events
0.0	1.7	ST_ERK1_ERK2_MAPK_PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.8	PID_ARF6_TRAFFICKING_PATHWAY	Arf6 trafficking events
0.0	0.6	PID_ARF6_DOWNSTREAM_PATHWAY	Arf6 downstream pathway
0.0	3.1	PID_CMYB_PATHWAY	C-MYB transcription factor network
0.0	1.8	PID_MYC_REPRESS_PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.7	PID_NCADHERIN_PATHWAY	N-cadherin signaling events
0.0	0.3	PID_WNT_CANONICAL_PATHWAY	Canonical Wnt signaling pathway
0.0	0.6	PID_RHOA_PATHWAY	RhoA signaling pathway
0.0	0.8	PID_TNF_PATHWAY	TNF receptor signaling pathway
0.0	0.6	PID_PI3KCI_PATHWAY	Class I PI3K signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	11.5	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3	2.4	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	Genes involved in Transport of organic anions
0.2	2.4	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	3.7	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.2	2.0	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	5.6	REACTOME_COLLAGEN_FORMATION	Genes involved in Collagen formation
0.1	2.3	REACTOME_GLUTATHIONE_CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.2	REACTOME_INFLAMMASOMES	Genes involved in Inflammasomes
0.1	2.1	REACTOME_PLC_BETA_MEDIATED_EVENTS	Genes involved in PLC beta mediated events
0.1	2.7	REACTOME_LYSOSOME_VESICLE_BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	4.3	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.6	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	0.7	REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.7	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	1.1	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	1.6	REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	1.2	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.2	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.3	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.6	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.4	REACTOME_CHOLESTEROL_BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	2.8	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.7	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.3	REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle

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