Motif ID: Pou2f2_Pou3f1

Z-value: 2.191

Transcription factors associated with Pou2f2_Pou3f1:

Gene SymbolEntrez IDGene Name
Pou2f2 ENSMUSG00000008496.12 Pou2f2
Pou3f1 ENSMUSG00000090125.2 Pou3f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f1mm10_v2_chr4_+_124657646_124657656-0.832.9e-15Click!
Pou2f2mm10_v2_chr7_-_25132473_25132512-0.501.2e-04Click!


Activity profile for motif Pou2f2_Pou3f1.

activity profile for motif Pou2f2_Pou3f1


Sorted Z-values histogram for motif Pou2f2_Pou3f1

Sorted Z-values for motif Pou2f2_Pou3f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou2f2_Pou3f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_45017953 38.415 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr14_+_67234620 30.328 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_67037399 29.685 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr2_+_25180737 25.082 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr6_+_8949670 24.534 ENSMUST00000060369.3
 Nxph1
neurexophilin 1
chr13_-_56252163 24.062 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr17_-_58991343 20.917 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr2_-_36105271 20.570 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr2_+_105675478 20.227 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr2_+_105675429 19.579 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr12_+_89812467 19.043 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chr2_+_172549581 16.286 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr13_+_23746734 15.900 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr3_+_83766300 15.872 ENSMUST00000029625.7
 Sfrp2
secreted frizzled-related protein 2
chr13_+_21722057 15.602 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr2_+_103566304 15.546 ENSMUST00000076212.3
 Abtb2
ankyrin repeat and BTB (POZ) domain containing 2
chr8_+_12395287 15.061 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr11_+_95337012 14.719 ENSMUST00000037502.6
 Fam117a
family with sequence similarity 117, member A
chr8_+_108714644 13.977 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr1_+_6730051 13.847 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 69.7 GO:0006342 chromatin silencing(GO:0006342)
3.2 42.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
8.0 39.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.8 38.4 GO:0060325 face morphogenesis(GO:0060325)
2.9 35.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.3 32.9 GO:0006334 nucleosome assembly(GO:0006334)
2.6 31.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.9 31.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.8 30.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
1.7 28.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
4.3 25.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
3.1 25.1 GO:0014807 regulation of somitogenesis(GO:0014807)
6.0 24.1 GO:0021648 zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648)
0.5 23.2 GO:0006284 base-excision repair(GO:0006284)
6.9 20.8 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.5 18.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
5.4 16.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
5.3 15.9 GO:1904956 dermatome development(GO:0061054) sclerotome development(GO:0061056) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.8 15.5 GO:0097237 cellular response to toxic substance(GO:0097237)
1.3 15.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 118.1 GO:0005634 nucleus(GO:0005634)
0.3 84.4 GO:0000790 nuclear chromatin(GO:0000790)
1.0 68.4 GO:0000786 nucleosome(GO:0000786)
0.1 58.4 GO:0005912 adherens junction(GO:0005912)
0.3 36.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 33.2 GO:0016607 nuclear speck(GO:0016607)
0.0 29.6 GO:0005615 extracellular space(GO:0005615)
7.0 28.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 25.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 23.3 GO:0017053 transcriptional repressor complex(GO:0017053)
3.3 23.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
4.1 20.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.8 20.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 16.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 14.2 GO:0016605 PML body(GO:0016605)
1.1 13.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 12.2 GO:0042734 presynaptic membrane(GO:0042734)
0.1 11.6 GO:0043204 perikaryon(GO:0043204)
1.4 11.4 GO:0033269 internode region of axon(GO:0033269)
2.0 10.1 GO:0005826 actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 144.6 GO:0003677 DNA binding(GO:0003677)
0.6 127.2 GO:0001047 core promoter binding(GO:0001047)
0.3 99.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
3.9 63.0 GO:0003680 AT DNA binding(GO:0003680)
0.6 38.4 GO:0019003 GDP binding(GO:0019003)
0.6 29.8 GO:0070888 E-box binding(GO:0070888)
0.1 22.1 GO:0051015 actin filament binding(GO:0051015)
0.9 21.2 GO:0000400 four-way junction DNA binding(GO:0000400)
1.7 18.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.8 15.9 GO:0061133 endopeptidase activator activity(GO:0061133)
2.7 13.7 GO:0043515 kinetochore binding(GO:0043515)
0.4 13.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 13.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 13.2 GO:0005096 GTPase activator activity(GO:0005096)
0.8 13.0 GO:0030957 Tat protein binding(GO:0030957)
2.0 11.9 GO:0070644 vitamin D response element binding(GO:0070644)
3.8 11.3 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.6 9.4 GO:0071837 HMG box domain binding(GO:0071837)
0.5 9.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.0 8.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 43.2 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
1.2 42.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
1.3 41.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 35.0 PID_CDC42_PATHWAY CDC42 signaling events
0.7 28.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 26.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 23.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.3 17.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 12.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 11.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 8.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 8.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 7.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 7.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.2 6.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 6.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 4.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 2.3 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 113.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
2.8 39.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
2.4 38.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.9 23.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.9 23.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.6 17.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 14.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.9 13.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.7 11.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 10.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 8.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 7.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 6.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.5 5.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 4.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 4.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.9 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 3.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.5 REACTOME_AMYLOIDS Genes involved in Amyloids