Motif ID: Pou3f4

Z-value: 0.577


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f4mm10_v2_chrX_+_110814390_110814413-0.383.9e-03Click!


Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 4.148 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr15_-_79285502 4.007 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr1_+_159737510 3.788 ENSMUST00000111669.3
Tnr
tenascin R
chr16_-_22439570 3.534 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr13_-_92030897 2.694 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr15_+_92161343 2.620 ENSMUST00000068378.5
Cntn1
contactin 1
chr7_+_87803815 2.608 ENSMUST00000125009.1
ENSMUST00000155358.1
Grm5

glutamate receptor, metabotropic 5

chr6_+_17463749 2.407 ENSMUST00000115443.1
Met
met proto-oncogene
chr3_+_68869563 2.374 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr6_-_36811361 2.310 ENSMUST00000101534.1
Ptn
pleiotrophin
chr2_-_120245157 2.272 ENSMUST00000090071.4
Pla2g4e
phospholipase A2, group IVE
chr6_+_17463826 2.004 ENSMUST00000140070.1
Met
met proto-oncogene
chr3_+_67892189 1.993 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr6_+_21215472 1.935 ENSMUST00000081542.5
Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr13_+_29016267 1.908 ENSMUST00000140415.1
A330102I10Rik
RIKEN cDNA A330102I10 gene
chr3_+_26331150 1.818 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr8_-_84773381 1.751 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr14_-_30353468 1.738 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_110061319 1.721 ENSMUST00000098110.2
AA474408
expressed sequence AA474408
chr3_+_68572245 1.663 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 4.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 4.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.9 3.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 3.3 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.2 2.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 2.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.9 2.6 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.0 2.6 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.8 2.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 2.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 2.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.9 GO:0045475 locomotor rhythm(GO:0045475)
0.0 1.9 GO:0007416 synapse assembly(GO:0007416)
0.1 1.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.4 1.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 1.7 GO:0001553 luteinization(GO:0001553)
0.1 1.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.5 1.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.5 1.5 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 4.6 GO:0009925 basal plasma membrane(GO:0009925)
0.4 4.0 GO:0071439 clathrin complex(GO:0071439)
1.3 3.8 GO:0072534 perineuronal net(GO:0072534)
0.2 2.6 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.8 GO:0043034 costamere(GO:0043034)
0.2 1.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 1.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 0.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 3.8 GO:0046625 sphingolipid binding(GO:0046625)
0.4 2.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 2.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.7 2.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 2.6 GO:0005516 calmodulin binding(GO:0005516)
0.8 2.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 2.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 2.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.4 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.7 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 1.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 3.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.9 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 0.8 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex