Motif ID: Pou4f1_Pou6f1

Z-value: 0.729

Transcription factors associated with Pou4f1_Pou6f1:

Gene SymbolEntrez IDGene Name
Pou4f1 ENSMUSG00000048349.8 Pou4f1
Pou6f1 ENSMUSG00000009739.10 Pou6f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f1mm10_v2_chr15_-_100599983_1006000390.584.2e-06Click!
Pou4f1mm10_v2_chr14_-_104467984_104468041-0.439.1e-04Click!


Activity profile for motif Pou4f1_Pou6f1.

activity profile for motif Pou4f1_Pou6f1


Sorted Z-values histogram for motif Pou4f1_Pou6f1

Sorted Z-values for motif Pou4f1_Pou6f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou4f1_Pou6f1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_42681513 6.081 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr14_-_30353468 4.969 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr15_+_92161343 4.963 ENSMUST00000068378.5
 Cntn1
contactin 1
chr1_-_56978534 3.615 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr10_-_64090241 3.556 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_-_50094277 3.484 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr9_+_113812547 3.353 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr11_-_42182924 3.099 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr15_-_100599864 3.020 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr18_+_37504264 2.945 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr16_-_22439570 2.929 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr8_+_12984246 2.924 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr4_+_152338619 2.896 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr2_-_120245157 2.859 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr15_+_18818895 2.831 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr11_+_98348404 2.735 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr9_-_103222063 2.669 ENSMUST00000170904.1
 Trf
transferrin
chr16_-_22439719 2.591 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_+_68104671 2.590 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr9_-_40346290 2.514 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 5.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
1.1 5.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.2 5.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 5.0 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.3 4.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 4.6 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.3 4.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 4.3 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.7 3.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.5 3.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 3.3 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 3.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 3.1 GO:0071420 cellular response to histamine(GO:0071420)
0.2 3.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 2.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 2.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9 2.7 GO:0007621 negative regulation of female receptivity(GO:0007621)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 8.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.5 5.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 4.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.0 GO:0042641 actomyosin(GO:0042641)
0.0 3.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 3.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 3.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.8 3.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 3.4 GO:0030017 sarcomere(GO:0030017)
0.3 3.1 GO:0071439 clathrin complex(GO:0071439)
0.2 3.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 2.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.5 GO:0000139 Golgi membrane(GO:0000139)
0.2 2.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 2.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 6.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.6 5.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 5.0 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 4.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 3.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 3.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 3.3 GO:0000287 magnesium ion binding(GO:0000287)
0.5 3.1 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 3.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.7 2.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 2.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 2.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.9 2.7 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.4 2.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.6 2.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 2.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 4.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 3.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.1 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_INSULIN_PATHWAY Insulin Pathway
0.1 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 5.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 3.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 1.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 1.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.6 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors