Motif ID: Pou6f2_Pou4f2

Z-value: 0.680

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.358.7e-03Click!
Pou4f2mm10_v2_chr8_-_78436640_78436649-0.095.0e-01Click!


Activity profile for motif Pou6f2_Pou4f2.

activity profile for motif Pou6f2_Pou4f2


Sorted Z-values histogram for motif Pou6f2_Pou4f2

Sorted Z-values for motif Pou6f2_Pou4f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_56296551 9.367 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr1_+_153665666 7.054 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 6.672 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr12_-_112511136 6.466 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr1_+_153665587 4.892 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 4.511 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr5_+_139543889 4.436 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_+_99263224 3.922 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr4_-_58499398 2.890 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr6_-_138426735 2.768 ENSMUST00000162932.1
 Lmo3
LIM domain only 3
chr6_+_88724667 2.543 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr6_+_88724828 2.520 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr6_-_138422898 2.433 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr7_-_49636847 2.172 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_+_55782500 1.894 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_+_53771499 1.816 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_-_14621669 1.721 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr2_-_168767029 1.673 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_+_68572245 1.506 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr2_-_168767136 1.424 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 23.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
3.1 9.4 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 5.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.7 5.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.6 4.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.3 3.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.5 3.6 GO:0019532 oxalate transport(GO:0019532)
0.2 3.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 2.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 2.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 2.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 1.5 GO:0001553 luteinization(GO:0001553)
0.5 1.4 GO:0021759 globus pallidus development(GO:0021759)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.0 GO:0046549 retinal cone cell development(GO:0046549)
0.1 1.0 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 1.0 GO:0031424 keratinization(GO:0031424)
0.0 1.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.9 GO:0016198 axon choice point recognition(GO:0016198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 23.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 5.1 GO:0043196 varicosity(GO:0043196)
0.0 3.1 GO:0000792 heterochromatin(GO:0000792)
0.0 2.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.7 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.9 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.2 0.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.6 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.0 0.1 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 26.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.4 GO:0008009 chemokine activity(GO:0008009)
0.4 5.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 3.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 3.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 1.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 1.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 0.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 5.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 4.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 3.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters