Motif ID: Ppara

Z-value: 1.869


Transcription factors associated with Ppara:

Gene SymbolEntrez IDGene Name
Ppara ENSMUSG00000022383.7 Ppara



Activity profile for motif Ppara.

activity profile for motif Ppara


Sorted Z-values histogram for motif Ppara

Sorted Z-values for motif Ppara



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppara

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 20.239 ENSMUST00000168589.1
 Sla
src-like adaptor
chr12_+_61523889 17.182 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_67586520 14.827 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 14.722 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr13_-_9878998 14.131 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr1_-_162478004 13.742 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr17_-_35910032 12.729 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr17_-_35909626 12.468 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr7_+_91090728 11.822 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr15_+_80091320 11.815 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr11_+_42419729 11.680 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr8_+_124793061 11.586 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_-_44799643 11.559 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr8_+_124793013 11.260 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr17_-_91088726 11.135 ENSMUST00000072671.7
ENSMUST00000174331.1
ENSMUST00000161402.3
ENSMUST00000054059.8
 Nrxn1



neurexin I



chr12_+_109545390 11.048 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr5_+_150259922 11.017 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr11_+_7063423 10.819 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chrX_-_72656135 10.799 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr15_+_100761741 10.508 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 328 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 29.5 GO:0071420 cellular response to histamine(GO:0071420)
0.2 28.7 GO:0030041 actin filament polymerization(GO:0030041)
0.6 26.8 GO:0006376 mRNA splice site selection(GO:0006376)
8.4 25.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 23.3 GO:0051260 protein homooligomerization(GO:0051260)
1.2 22.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.8 20.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.0 19.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
2.1 18.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.6 18.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 17.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 16.7 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.8 16.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
4.0 16.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.6 15.9 GO:0008340 determination of adult lifespan(GO:0008340)
3.7 15.0 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.8 15.0 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 15.0 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
1.1 14.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 14.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 40.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 38.2 GO:0016021 integral component of membrane(GO:0016021)
0.3 37.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 34.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 33.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 30.3 GO:0005635 nuclear envelope(GO:0005635)
0.2 30.2 GO:0005884 actin filament(GO:0005884)
0.2 26.9 GO:0030427 site of polarized growth(GO:0030427)
1.2 24.4 GO:0032279 asymmetric synapse(GO:0032279)
2.2 20.1 GO:0097427 microtubule bundle(GO:0097427)
2.0 18.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 18.3 GO:0045202 synapse(GO:0045202)
0.9 17.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.6 16.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.4 15.9 GO:0032809 neuronal cell body membrane(GO:0032809)
3.0 15.0 GO:0044316 cone cell pedicle(GO:0044316)
0.2 14.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 14.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
3.4 13.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.8 13.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.8 GO:0003779 actin binding(GO:0003779)
0.8 30.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.7 28.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.5 27.6 GO:0036002 pre-mRNA binding(GO:0036002)
4.2 25.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 21.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 20.7 GO:0005158 insulin receptor binding(GO:0005158)
0.7 20.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.0 17.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.6 17.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.4 16.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 16.4 GO:0030507 spectrin binding(GO:0030507)
3.9 15.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.8 15.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.4 15.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 15.0 GO:0030552 cAMP binding(GO:0030552)
0.1 14.7 GO:0017124 SH3 domain binding(GO:0017124)
3.5 14.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
4.6 13.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.0 13.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 20.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.3 14.7 PID_FGF_PATHWAY FGF signaling pathway
0.6 14.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 11.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 9.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.5 9.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 8.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.6 8.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.4 7.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.3 7.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 6.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 6.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 4.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 4.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 4.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.3 4.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 4.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 4.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 40.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.2 38.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 22.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 21.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.8 21.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.3 16.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.9 15.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.8 14.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 13.7 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.9 13.4 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.5 13.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 11.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.3 10.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.4 9.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 9.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 8.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 8.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 8.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 8.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 7.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs